The Role of Orexin Receptor Antagonists in Inhibiting Drug Addiction: A Review Article.
Addiction
Dependence
Hypocretin
Orexin
Tolerance
Withdrawal
Journal
Addiction & health
ISSN: 2008-4633
Titre abrégé: Addict Health
Pays: Iran
ID NLM: 101582275
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
received:
29
07
2023
accepted:
15
04
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
ppublish
Résumé
The orexinergic system and its receptors are involved in many physiological processes. Their functions in energy homeostasis, arousal, cognition, stress processing, endocrine functions, and pain modulation have been investigated. Many studies have shown that the orexinergic system cooperates with the dopaminergic system in the addiction process. Emerging evidence suggests that the orexinergic system can be effective in the induction of drug dependence and tolerance. Therefore, several researches have been conducted on the effect of orexin receptor (OXR) antagonists on reducing tolerance and dependence caused by drug abuse. Due to the significant growth of the studies on the orexinergic system, the current literature was conducted to collect the findings of previous studies on orexin and its receptors in the induction of drug addiction. In addition, cellular and molecular mechanisms of the possible role of orexin in drug tolerance and dependence are discussed. The findings indicate that the administration of OXR antagonists reduces drug dependence. OXR blockers seem to counteract the addictive effects of drugs through multiple mechanisms, such as preventing neuronal adaptation. This review proposes the potential clinical use of OXR antagonists in the treatment of drug dependence.
Identifiants
pubmed: 39051042
doi: 10.34172/ahj.2024.1491
pmc: PMC11264478
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
130-139Informations de copyright
© 2024 Kerman University of Medical Sciences.
Déclaration de conflit d'intérêts
Competing Interests The authors declare none.
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