[Compound


Journal

Nan fang yi ke da xue xue bao = Journal of Southern Medical University
ISSN: 1673-4254
Titre abrégé: Nan Fang Yi Ke Da Xue Xue Bao
Pays: China
ID NLM: 101266132

Informations de publication

Date de publication:
20 Jul 2024
Historique:
medline: 26 7 2024
pubmed: 26 7 2024
entrez: 25 7 2024
Statut: ppublish

Résumé

To explore the therapeutic mechanism of compound Drugbank, Gene Cards, OMIM and PharmGKb databases were used to obtain DCM-related targets, and the core targets were identified and functionally annotated by protein-protein interaction network analysis followed by GO and KEGG enrichment analysis. The "Traditional Chinese Medicine-Key Component-Key Target-Key Pathway" network was constructed using Cytoscape 3.9.1, and molecular docking was carried out for the key components and the core targets. In the animal experiment, Wistar rat models of DCM were treated with normal saline or We identified 61 active compounds in The therapeutic effect of compound

Identifiants

pubmed: 39051076
doi: 10.12122/j.issn.1673-4254.2024.07.10
doi:

Substances chimiques

Proto-Oncogene Proteins c-akt EC 2.7.11.1
Phosphatidylinositol 3-Kinases EC 2.7.1.-
Drugs, Chinese Herbal 0
Interleukin-6 0

Types de publication

English Abstract Journal Article

Langues

chi

Sous-ensembles de citation

IM

Pagination

1306-1314

Auteurs

W Zhang (W)

College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830057, China.

H Gu (H)

College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830057, China.

P Chen (P)

College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830057, China.

S Wu (S)

College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830057, China.

H Ma (H)

College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830057, China.
Xinjiang Key Laboratory of Famous Prescription and Science of Formulas, Urumqi 830057, China.

L Yao (L)

College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830057, China.
Xinjiang Key Laboratory of Famous Prescription and Science of Formulas, Urumqi 830057, China.

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Classifications MeSH