[Compound
Animals
Rats
Proto-Oncogene Proteins c-akt
/ metabolism
Phosphatidylinositol 3-Kinases
/ metabolism
Drugs, Chinese Herbal
/ pharmacology
Signal Transduction
/ drug effects
Diabetic Cardiomyopathies
/ metabolism
Apoptosis
/ drug effects
Rats, Wistar
Molecular Docking Simulation
Diabetes Mellitus, Experimental
/ metabolism
Inflammation
/ metabolism
Myocardium
/ metabolism
Male
Interleukin-6
/ metabolism
compound Yuye Decoction
diabetic cardiomyopathy
network pharmacology
Journal
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
ISSN: 1673-4254
Titre abrégé: Nan Fang Yi Ke Da Xue Xue Bao
Pays: China
ID NLM: 101266132
Informations de publication
Date de publication:
20 Jul 2024
20 Jul 2024
Historique:
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
ppublish
Résumé
To explore the therapeutic mechanism of compound Drugbank, Gene Cards, OMIM and PharmGKb databases were used to obtain DCM-related targets, and the core targets were identified and functionally annotated by protein-protein interaction network analysis followed by GO and KEGG enrichment analysis. The "Traditional Chinese Medicine-Key Component-Key Target-Key Pathway" network was constructed using Cytoscape 3.9.1, and molecular docking was carried out for the key components and the core targets. In the animal experiment, Wistar rat models of DCM were treated with normal saline or We identified 61 active compounds in The therapeutic effect of compound
Identifiants
pubmed: 39051076
doi: 10.12122/j.issn.1673-4254.2024.07.10
doi:
Substances chimiques
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Drugs, Chinese Herbal
0
Interleukin-6
0
Types de publication
English Abstract
Journal Article
Langues
chi
Sous-ensembles de citation
IM