Efficacy and Safety of Rescue Treatment with Plasma Exchange in Patients with Acute Inflammatory Neurological Disorders: A Single Center Experience.
CIDP
NMOSD
adverse events
effectiveness
intravenous immunoglobulin
multiple sclerosis
myasthenia gravis
pathogenetic antibodies
plasma exchange
rescue therapy
Journal
Neurology international
ISSN: 2035-8385
Titre abrégé: Neurol Int
Pays: Switzerland
ID NLM: 101551564
Informations de publication
Date de publication:
10 Jul 2024
10 Jul 2024
Historique:
received:
29
05
2024
revised:
03
07
2024
accepted:
08
07
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
epublish
Résumé
Therapeutic plasma exchange (TPE) is a highly effective rescue treatment for patients with acute exacerbation of neuroimmunological disease that removes circulating autoantibodies and inflammatory components from the bloodstream. The aims of this study are to explore the safety and the effectiveness of TPE in patients with autoimmune neurological disorders. We retrospectively evaluated the frequency of adverse events (AEs) and the effectiveness of TPE using the modified Ranking Scale (mRS) in patients with acute neurological flares who underwent TPE at the University Hospital of Palermo. Of 59 patients, the majority underwent TPE due to multiple sclerosis (MS) relapse. In 23.7% of cases, TPE was performed before obtaining a definite diagnosis due to the severity of the clinical presentation. After TPE, the mRS score was globally reduced ( These results highlight the early use of TPE in patients with circulating pathogenetic antibodies as well as its favorable safety profile.
Sections du résumé
BACKGROUND
BACKGROUND
Therapeutic plasma exchange (TPE) is a highly effective rescue treatment for patients with acute exacerbation of neuroimmunological disease that removes circulating autoantibodies and inflammatory components from the bloodstream. The aims of this study are to explore the safety and the effectiveness of TPE in patients with autoimmune neurological disorders.
METHODS
METHODS
We retrospectively evaluated the frequency of adverse events (AEs) and the effectiveness of TPE using the modified Ranking Scale (mRS) in patients with acute neurological flares who underwent TPE at the University Hospital of Palermo.
RESULTS
RESULTS
Of 59 patients, the majority underwent TPE due to multiple sclerosis (MS) relapse. In 23.7% of cases, TPE was performed before obtaining a definite diagnosis due to the severity of the clinical presentation. After TPE, the mRS score was globally reduced (
CONCLUSIONS
CONCLUSIONS
These results highlight the early use of TPE in patients with circulating pathogenetic antibodies as well as its favorable safety profile.
Identifiants
pubmed: 39051217
pii: neurolint16040056
doi: 10.3390/neurolint16040056
doi:
Types de publication
Journal Article
Langues
eng