Foldamer-Based Mechanoresponsive Materials: Molecular Nanoarchitectonics to Advanced Functions.

Artificial molecules that respond to external stimuli such as light, heat, chemical signals, and mechanical force have garnered significant interest due to their tunable functions, variable optical properties, and mechanical responses. Particularly, mechanoresponsive materials featuring molecules that respond to mechanical stress or show force-induced optical changes have been intriguing due to their extraordinary functions. Despite the promising potential of many such materials reported in the past, practical applications have remained limited, primarily because their functions often depend on irreversible covalent bond rupture. Foldamers, oligomers that fold into well-defined secondary structures, offer an alternative class of mechanoactive motifs. These molecules can reversibly sustain mechanical stress and efficiently dissipate energy by transitioning between folded and unfolded states. This review focuses on the emerging properties of foldamer-based mechanoresponsive materials. We begin by highlighting the mechanical responses of foldamers in their molecular form, which have been primarily investigated using single-molecule force spectroscopy and other analytical methods. Following this, we provide a detailed survey of the current trends in foldamer-appended polymers, emphasizing their emerging mechanical and mechanochromic properties. Subsequently, we present an overview of the state-of-the-art advancements in foldamer-appended polymers, showcasing significant reports in this field. This review covers some of the most recent advances in this direction and draws a perspective for further development.