Functional and structural brain connectivity in disorders of consciousness.
Consciousness
Disorders of consciousness
Functional connectivity
Global neuronal workspace
Structural connectivity
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
25 Jul 2024
25 Jul 2024
Historique:
received:
01
11
2023
accepted:
12
07
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
aheadofprint
Résumé
Brain connectivity, allowing information to be shared between distinct cortical areas and thus to be processed in an integrated way, has long been considered critical for consciousness. However, the relationship between functional intercortical interactions and the structural connections thought to underlie them is poorly understood. In the present work, we explore both functional (with an EEG-based metric: the median weighted symbolic mutual information in the theta band) and structural (with a brain MRI-based metric: fractional anisotropy) connectivities in a cohort of 78 patients with disorders of consciousness. Both metrics could distinguish patients in a vegetative state from patients in minimally conscious state. Crucially, we discovered a significant positive correlation between functional and structural connectivities. Furthermore, we showed that this structure-function relationship is more specifically observed when considering structural connectivity within the intra- and inter-hemispheric long-distance cortico-cortical bundles involved in the Global Neuronal Workspace (GNW) theory of consciousness, thus supporting predictions of this model. Altogether, these results support the interest of multimodal assessments of brain connectivity in refining the diagnostic evaluation of patients with disorders of consciousness.
Identifiants
pubmed: 39052096
doi: 10.1007/s00429-024-02839-8
pii: 10.1007/s00429-024-02839-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Académie des Sciences, Institut de France
ID : Lamonica Prize 2016
Organisme : Agence Nationale de la Recherche
ID : Investissements d'avenir ANR-10-IAIHU-06 program
Organisme : Agence Nationale de la Recherche
ID : Investissements d'avenir ANR-10-IAIHU-06 program
Organisme : Agence Nationale de la Recherche
ID : Investissements d'avenir ANR-10-IAIHU-06 program
Organisme : European Commission
ID : PerMed grant
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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