Postoperative Delirium and Neurocognitive Disorders: Updates for Providers Caring for Cancer Patients.

Cancer Delayed neurocognitive recovery Perioperative neurocognitive disorders Postoperative cognitive dysfunction Postoperative delirium Postoperative neurocognitive disorder

Journal

Current oncology reports

ISSN: 1534-6269

Titre abrégé: Curr Oncol Rep

Pays: United States

ID NLM: 100888967

Informations de publication

Date de publication:
25 Jul 2024

Historique:

accepted: 15 07 2024

medline: 26 7 2024

pubmed: 26 7 2024

entrez: 25 7 2024

Statut: aheadofprint

Résumé

To provide up to date information on postoperative delirium and neurocognitive disorders in surgical cancer patients. Established risk factors such as age, psychosocial factors, comorbidities, frailty and preexisting cognitive decline continue to exhibit associations with perioperative neurocognitive disorders (PND); novel risk factors identified recently include microbiome composition and vitamin D deficiency. Prevention measures include cognitive prehabilitation, perioperative geriatric assessment and multidisciplinary care, dexmedetomidine and multimodal analgesic techniques. Studies investigating ciprofol, remimazolam, esketamine, ramelteon and suvorexant have shown encouraging results. Controversy remains regarding the use of inhalational versus intravenous general anesthesia. Innovative approaches to address PND are a rapidly developing area of research, but more studies are needed to identify effective prevention and management interventions. Despite challenges and controversy in the field, implementation of best practice can reduce the detrimental impact of PND on patients, caregivers, and society at large.

Identifiants

DOI: 10.1007/s11912-024-01584-9 PMID: 39052230

pubmed: 39052230

doi: 10.1007/s11912-024-01584-9

pii: 10.1007/s11912-024-01584-9

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Informations de copyright

Références

DSM Library. [cited 2024 Apr 26]. Diagnostic and Statistical Manual of Mental Disorders. https://dsm.psychiatryonline.org/doi/book/10.1176/appi.books.9780890425596

Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, et al. Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018. Br J Anaesth. 2018;121(5):1005–12.

pubmed: 30336844 pmcid: 7069032 doi: 10.1016/j.bja.2017.11.087

Daksla N, Nguyen V, Jin Z, Bergese SD. Brain prehabilitation for oncologic surgery. Curr Oncol Rep. 2022;24(11):1513–20.

pubmed: 35900715 pmcid: 9606060 doi: 10.1007/s11912-022-01312-1

Chesney TR, Daza JF, Wong CL. Geriatric assessment and treatment decision-making in surgical oncology. Curr Opin Support Palliat Care. 2023;17(1):22–30.

pubmed: 36695865 doi: 10.1097/SPC.0000000000000635

Ho MH, Nealon J, Igwe E, Traynor V, Chang HC (Rita), Chen KH Postoperative Delirium in Older Patients, et al. editors. A Systematic Review of Assessment and Incidence of Postoperative Delirium. Worldviews Evid Based Nurs. 2021;18(5):290–301.

O’Hanlon S, Baxter M, Hosie A. Postoperative delirium in older patients with cancer: the role of psychological distress and social support. Curr Opin Support Palliat Care. 2022;16(1):38–47.

pubmed: 34939608 doi: 10.1097/SPC.0000000000000588

Zhao B, Ji HS, Xu CY, Li DJ, Xing ZQ, Liu B, et al. Incidence and risk factors of postoperative delirium after pancreatic cancer surgery: a retrospective study. Surg Today. 2023;53(6):736–42.

pubmed: 36335219 doi: 10.1007/s00595-022-02614-4

Ho MH, Li PWC, Lin YK, Lee JJ, Lin CC. Incidence of postoperative delirium in cancer patients after head and neck surgery: a proportional meta-analysis. Otolaryngol–Head Neck Surg off J Am Acad Otolaryngol-Head Neck Surg. 2024;170(2):335–46.

doi: 10.1002/ohn.557

Ke Y, Chew S, Seet E, Wong WY, Lim V, Chua N, et al. Risk factors of post-anaesthesia care unit delirium in patients undergoing non-cardiac surgery in Singapore. Singap Med J. 2023;64(12):728–31.

doi: 10.11622/smedj.2021129

Goldstein DP, Blasco M, de Almeida J, Su J, Xu W, Cohen M, et al. Cognitive impairment and delirium in older patients undergoing major head and neck surgery. Otolaryngol–Head Neck Surg off J Am Acad Otolaryngol-Head Neck Surg. 2022;167(1):97–9.

doi: 10.1177/01945998211045293

Kandula RA, Borne G, Kandregula S, Beyl R, Nathan CAO. Impact of dementia on the postoperative outcomes in patients undergoing surgery for head and neck cancers: a national study. Laryngoscope. 2024;134(3):1258–64.

pubmed: 37602750 doi: 10.1002/lary.30988

Yajima S, Nakanishi Y, Sugimoto M, Kobayashi S, Kudo M, Yasujima R, et al. A novel predictive model for postoperative delirium using multiple geriatric screening factors. J Surg Oncol. 2023;127(6):1071–8.

pubmed: 36695780 doi: 10.1002/jso.27206

Hoffmann AJ, Tin AL, Vickers AJ, Shahrokni A. Preoperative frailty vs. cognitive impairment: which one matters most for postoperative delirium among older adults with cancer? J Geriatr Oncol. 2023;14(4):101479.

pubmed: 37001348 pmcid: 10530636 doi: 10.1016/j.jgo.2023.101479

Yajima S, Nakanishi Y, Matsumoto S, Ookubo N, Tanabe K, Kataoka M, et al. The Mini-cog: a simple screening tool for cognitive impairment useful in predicting the risk of delirium after major urological cancer surgery. Geriatr Gerontol Int. 2022;22(4):319–24.

pubmed: 35253337 doi: 10.1111/ggi.14367

Wang Y, Yu H, Qiao H, Li C, Chen K, Shen X. Risk factors and incidence of postoperative delirium in patients undergoing laryngectomy. Otolaryngol–Head Neck Surg off J Am Acad Otolaryngol-Head Neck Surg. 2019;161(5):807–13.

doi: 10.1177/0194599819864304

Densky J, Eskander A, Kang S, Chan J, Tweel B, Sitapara J, et al. Risk factors Associated with postoperative delirium in patients undergoing head and neck free flap reconstruction. JAMA Otolaryngol– Head Neck Surg. 2019;145(3):216–21.

pubmed: 30605208 pmcid: 6439748 doi: 10.1001/jamaoto.2018.3820

Liu Y, Zhang X, Jiang M, Zhang Y, Wang C, Sun Y, et al. Impact of preoperative sleep disturbances on postoperative delirium in patients with intracranial tumors: a prospective, observational, cohort study. Nat Sci Sleep. 2023;15:1093–105.

pubmed: 38149043 pmcid: 10749794 doi: 10.2147/NSS.S432829

Ishibashi H, Wakejima R, Asakawa A, Sugita Y, Ishikawa Y, Hanafusa M, et al. Postoperative delirium in lung cancer anatomical resection-analysis of risk factors and prognosis. World J Surg. 2022;46(5):1196–206.

pubmed: 35028705 doi: 10.1007/s00268-022-06442-y

Yang Z, Wang XF, Yang LF, Fang C, Gu XK, Guo HW. Prevalence and risk factors for postoperative delirium in patients with colorectal carcinoma: a systematic review and meta-analysis. Int J Colorectal Dis. 2020;35(3):547–57.

pubmed: 31955218 doi: 10.1007/s00384-020-03505-1

Yanagisawa T, Tatematsu N, Horiuchi M, Migitaka S, Yasuda S, Itatsu K, et al. Preoperative low physical activity is a predictor of postoperative delirium in patients with gastrointestinal cancer: a retrospective study. Asian Pac J Cancer Prev APJCP. 2022;23(5):1753–9.

pubmed: 35633561 doi: 10.31557/APJCP.2022.23.5.1753

Crawford JE, Zubair F, Baniulyte G, Wales CJ, Ansell M, Thomson E, et al. Postoperative delirium in patients with head and neck oral cancer in the West of Scotland. Br J Oral Maxillofac Surg. 2021;59(3):353–61.

pubmed: 33358010 doi: 10.1016/j.bjoms.2020.08.116

Nomi T, Kaibori M, Hirokawa F, Ueno M, Hokuto D, Noda T, et al. Effect of laparoscopic liver resection on postoperative delirium in elderly patients with hepatocellular carcinoma. J Hepato-Biliary-Pancreat Sci. 2023;30(9):1111–8.

doi: 10.1002/jhbp.1341

Dong B, Yu D, Jiang L, Liu M, Li J. Incidence and risk factors for postoperative delirium after head and neck cancer surgery: an updated meta-analysis. BMC Neurol. 2023;23(1):371.

pubmed: 37848819 pmcid: 10580509 doi: 10.1186/s12883-023-03418-w

Papaconstantinou D, Frountzas M, Ruurda JP, Mantziari S, Tsilimigras DI, Koliakos N, et al. Risk factors and consequences of post-esophagectomy delirium: a systematic review and meta-analysis. Dis Esophagus off J Int Soc Dis Esophagus. 2023;36(8):doac103.

doi: 10.1093/dote/doac103

Tian JY, Hao XY, Cao FY, Liu JJ, Li YX, Guo YX, et al. Preoperative Frailty Assessment predicts postoperative mortality, delirium and pneumonia in elderly lung cancer patients: a retrospective cohort study. Ann Surg Oncol. 2023;30(12):7442–51.

pubmed: 37326809 doi: 10.1245/s10434-023-13696-w

Tsai CY, Liu KH, Lai CC, Hsu JT, Hsueh SW, Hung CY, et al. Association of preoperative frailty and postoperative delirium in older cancer patients undergoing elective abdominal surgery: a prospective observational study in Taiwan. Biomed J. 2023;46(4):100557.

pubmed: 35985478 doi: 10.1016/j.bj.2022.08.003

Arita A, Takahashi H, Ogino T, Miyoshi N, Uemura M, Akasaka H, et al. Grip strength as a predictor of postoperative delirium in patients with colorectal cancers. Ann Gastroenterol Surg. 2022;6(2):265–72.

pubmed: 35261952 doi: 10.1002/ags3.12519

Sugi T, Enomoto T, Ohara Y, Furuya K, Kitaguchi D, Moue S, et al. Risk factors for postoperative delirium in elderly patients undergoing gastroenterological surgery: a single-center retrospective study. Ann Gastroenterol Surg. 2023;7(5):832–40.

pubmed: 37663963 pmcid: 10472384 doi: 10.1002/ags3.12676

Panel B. The 2019 AGSBCUE. American Geriatrics Society 2019 Updated AGS Beers Criteria

doi: 10.1111/jgs.15767

Mueller A, Spies CD, Eckardt R, Weiss B, Pohrt A, Wernecke KD, et al. Anticholinergic burden of long-term medication is an independent risk factor for the development of postoperative delirium: a clinical trial. J Clin Anesth. 2020;61:109632.

pubmed: 31668693 doi: 10.1016/j.jclinane.2019.109632

Liu Q, Li L, Wei J, Xie Y. Correlation and influencing factors of preoperative anxiety, postoperative pain, and delirium in elderly patients undergoing gastrointestinal cancer surgery. BMC Anesthesiol. 2023;23(1):78.

pubmed: 36915054 pmcid: 10009960 doi: 10.1186/s12871-023-02036-w

Lai CC, Liu KH, Tsai CY, Hsu JT, Hsueh SW, Hung CY, et al. Risk factors and effect of postoperative delirium on adverse surgical outcomes in older adults after elective abdominal cancer surgery in Taiwan. Asian J Surg. 2023;46(3):1199–206.

pubmed: 36041906 doi: 10.1016/j.asjsur.2022.08.079

Dezube AR, Bravo-Iñiguez CE, Yelamanchili N, De León LE, Tarascio J, Jaklitsch MT, et al. Risk factors for delirium after esophagectomy. J Surg Oncol. 2020;121(4):645–53.

pubmed: 31919865 doi: 10.1002/jso.25835

Obermeier KT, Kraus M, Smolka W, Henkel J, Saller T, Otto S, et al. Postoperative delirium in patients with oral Cancer: is intraoperative Fluid Administration a neglected risk factor? Cancers. 2022;14(13):3176.

pubmed: 35804948 pmcid: 9265071 doi: 10.3390/cancers14133176

Chen J, Ji X, Xing H. Risk factors and a nomogram model for postoperative delirium in elderly gastric cancer patients after laparoscopic gastrectomy. World J Surg Oncol. 2022;20(1):319.

pubmed: 36171580 pmcid: 9520878 doi: 10.1186/s12957-022-02793-x

Safavynia SA, Arora S, Pryor KO, García PS. An update on postoperative delirium: clinical features, neuropathogenesis, and perioperative management. Curr Anesthesiol Rep. 2018;8(3):252–62.

pubmed: 30555281 pmcid: 6290904 doi: 10.1007/s40140-018-0282-5

Sun Y, Peng HP, Wu TT. Postoperative C-Reactive protein predicts postoperative delirium in Colorectal Cancer following surgery. Clin Interv Aging. 2023;18:559–70.

pubmed: 37038607 pmcid: 10082577 doi: 10.2147/CIA.S387117

Xiang D, Xing H, Zhu Y. A predictive nomogram model for postoperative delirium in elderly patients following laparoscopic surgery for gynecologic cancers. Support Care Cancer off J Multinatl Assoc Support Care Cancer. 2022;31(1):24.

Khan SH, Lindroth H, Jawed Y, Wang S, Nasser J, Seyffert S, et al. Serum biomarkers in postoperative Delirium after Esophagectomy. Ann Thorac Surg. 2022;113(3):1000–7.

pubmed: 33774004 doi: 10.1016/j.athoracsur.2021.03.035

Brattinga B, Plas M, Spikman JM, Rutgers A, de Haan JJ, Absalom AR, et al. The association between the inflammatory response following surgery and post-operative delirium in older oncological patients: a prospective cohort study. Age Ageing. 2022;51(2):afab237.

pubmed: 35180288 pmcid: 9160877 doi: 10.1093/ageing/afab237

Mietani K, Hasegawa-Moriyama M, Yagi K, Inoue R, Ogata T, Shimojo N, et al. Elevation of serum plasminogen activator inhibitor-1 predicts postoperative delirium independent of neural damage: a sequential analysis. Sci Rep. 2022;12(1):17091.

pubmed: 36224337 pmcid: 9556513 doi: 10.1038/s41598-022-21682-7

Liu H, Cheng G, Xu YL, Fang Q, Ye L, Wang CH, et al. Preoperative status of Gut Microbiota predicts postoperative delirium in patients with gastric Cancer. Front Psychiatry. 2022;13:852269.

pubmed: 35308872 pmcid: 8929925 doi: 10.3389/fpsyt.2022.852269

Yang Z, Tong C, Qian X, Wang H, Wang Y. Mechanical Bowel Preparation is a risk factor for postoperative delirium as it alters the gut microbiota composition: a prospective randomized single-center study. Front Aging Neurosci. 2022;14:847610.

pubmed: 35444528 pmcid: 9014128 doi: 10.3389/fnagi.2022.847610

Rostoft S, Hamaker ME. Basic geriatric principles for colorectal surgeons: how to optimize assessment and care of older patients in the perioperative period. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2020;46(3):310–5.

Tarazona-Santabalbina FJ, Llabata-Broseta J, Belenguer-Varea Á, Álvarez-Martínez D, Cuesta-Peredo D, Avellana-Zaragoza JA. A daily multidisciplinary assessment of older adults undergoing elective colorectal cancer surgery is associated with reduced delirium and geriatric syndromes. J Geriatr Oncol. 2019;10(2):298–303.

pubmed: 30217699 doi: 10.1016/j.jgo.2018.08.013

Janssen TL, Steyerberg EW, Langenberg JCM, de Lepper CCHA, van Wielders H, Seerden D. Multimodal prehabilitation to reduce the incidence of delirium and other adverse events in elderly patients undergoing elective major abdominal surgery: an uncontrolled before-and-after study. PLoS ONE. 2019;14(6):e0218152.

pubmed: 31194798 pmcid: 6564537 doi: 10.1371/journal.pone.0218152

Takahashi N, Hiraki A, Kawahara K, Nagata M, Yoshida R, Matsuoka Y, et al. Postoperative delirium in patients undergoing tumor resection with reconstructive surgery for oral cancer. Mol Clin Oncol. 2021;14(3):60.

pubmed: 33604050 pmcid: 7849067 doi: 10.3892/mco.2021.2222

Yuan Y, Gu Q, Zhu M, Zhang Y, Lan M. Frailty-originated early rehabilitation reduces postoperative delirium in brain tumor patients: results from a prospective randomized study. Asia-Pac J Oncol Nurs. 2023;10(8):100263.

pubmed: 37497156 pmcid: 10365981 doi: 10.1016/j.apjon.2023.100263

Humeidan ML, Reyes JPC, Mavarez-Martinez A, Roeth C, Nguyen CM, Sheridan E, et al. Effect of cognitive prehabilitation on the incidence of postoperative delirium among older adults undergoing major noncardiac surgery: the Neurobics Randomized Clinical Trial. JAMA Surg. 2021;156(2):148–56.

pubmed: 33175114 doi: 10.1001/jamasurg.2020.4371

Guo R, Ye J, Liao B, Luo X, Rao P. The relationship between anesthesia and melatonin: a review. Front Pharmacol. 2023;14:1255752.

pubmed: 37795029 pmcid: 10546185 doi: 10.3389/fphar.2023.1255752

Huang Q, Shi Q, Yi X, Zeng J, Dai X, Lin L, et al. Effect of Repeated Intranasal Administration of different doses of insulin on postoperative delirium, serum τ and Aβ protein in Elderly patients undergoing radical esophageal Cancer surgery. Neuropsychiatr Dis Treat. 2023;19:1017–26.

pubmed: 37144143 pmcid: 10153451 doi: 10.2147/NDT.S405426

Huang Q, Li Q, Qin F, Yuan L, Lu Z, Nie H, et al. Repeated Preoperative Intranasal Administration of Insulin decreases the incidence of postoperative delirium in Elderly patients undergoing laparoscopic radical gastrointestinal surgery: a Randomized, Placebo-Controlled, double-blinded clinical study. Am J Geriatr Psychiatry off J Am Assoc Geriatr Psychiatry. 2021;29(12):1202–11.

doi: 10.1016/j.jagp.2021.02.043

Mayanagi S, Haneda R, Inoue M, Ishii K, Tsubosa Y. Ramelteon and suvorexant for postoperative delirium in elderly patients with esophageal cancer. Esophagus off J Jpn Esophageal Soc. 2023;20(4):635–42.

Ikeuchi S, Tanaka R, Sugiura T, Shinsato K, Wakabayashi A, Sato J, et al. Efficacy of combined use of Suvorexant and Ramelteon in preventing postoperative delirium: a retrospective comparative study. J Pharm Health Care Sci. 2023;9(1):42.

pubmed: 38037168 pmcid: 10691026 doi: 10.1186/s40780-023-00311-z

Shen L, Chen JQ, Yang XL, Hu JC, Gao W, Chai XQ, et al. Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium. Front Psychiatry. 2022;13:889637.

pubmed: 36117654 pmcid: 9470861 doi: 10.3389/fpsyt.2022.889637

Wada S, Sadahiro R, Matsuoka YJ, Uchitomi Y, Yamaguchi T, Sato T, et al. Yokukansan for treatment of preoperative anxiety and Prevention of Postoperative Delirium in Cancer patients undergoing highly invasive surgery. J-SUPPORT 1605 (ProD study): a Randomized, Double-Blind, placebo-controlled trial. J Pain Symptom Manage. 2021;61(1):71–80.

pubmed: 32800969 doi: 10.1016/j.jpainsymman.2020.07.009

Sadahiro R, Wada S, Matsuoka YJ, Uchitomi Y, Yamaguchi T, Sato T, et al. Prevention of delirium with agitation by Yokukansan in older adults after cancer surgery. Jpn J Clin Oncol. 2022;52(11):1276–81.

pubmed: 35907781 pmcid: 9631458

Won YJ, Oh SK, Lim BG, Kim YS, Lee DY, Lee JH. Effect of surgical pleth index-guided remifentanil administration on perioperative outcomes in elderly patients: a prospective randomized controlled trial. BMC Anesthesiol. 2023;23(1):57.

pubmed: 36803564 pmcid: 9936695 doi: 10.1186/s12871-023-02011-5

Liu T, Tuo J, Wei Q, Sun X, Zhao H, Zhao X, et al. Effects of Abdominal Wall blocks on Postoperative Delirium in Elderly patients undergoing laparoscopic surgery: a randomized controlled study. Med Sci Monit Int Med J Exp Clin Res. 2022;28:e934281.

Wei W, Zheng X, Gu Y, Fu W, Tang C, Yao Y. Effect of general anesthesia with thoracic paravertebral block on postoperative delirium in elderly patients undergoing thoracoscopic lobectomy: a randomized-controlled trial. BMC Anesthesiol. 2022;22(1):1.

pubmed: 34979943 pmcid: 8722018 doi: 10.1186/s12871-021-01532-1

Li S, Li R, Li M, Cui Q, Zhang X, Ma T, et al. Dexmedetomidine administration during brain tumour resection for prevention of postoperative delirium: a randomised trial. Br J Anaesth. 2023;130(2):e307–16.

pubmed: 36517290 doi: 10.1016/j.bja.2022.10.041

Xie K, Chen J, Tian L, Gu F, Pan Y, Huang Z, et al. Postoperative infusion of dexmedetomidine via intravenous patient-controlled analgesia for prevention of postoperative delirium in elderly patients undergoing surgery. Aging Clin Exp Res. 2023;35(10):2137–44.

pubmed: 37470916 pmcid: 10520140 doi: 10.1007/s40520-023-02497-6

Liu W, Wang Y, Chen K, Ye M, Lu W, Chen K, et al. Effect of intraoperative dexmedetomidine use on postoperative delirium in the Elderly after Laryngectomy: a Randomized Controlled Clinical Trial. Drug Des Devel Ther. 2023;17:2933–41.

pubmed: 37766822 pmcid: 10521928 doi: 10.2147/DDDT.S424526

Ding Y, Yu J, Cui F, Li J. Comparison of Intravenous and Inhalational Anesthetic on Postoperative Cognitive outcomes in Elderly patients Undergoing Cancer surgery: systematic review and Meta-analysis. J Perianesthesia Nurs off J Am Soc PeriAnesthesia Nurses. 2022;37(5):683–90.

doi: 10.1016/j.jopan.2021.11.017

Cao SJ, Zhang Y, Zhang YX, Zhao W, Pan LH, Sun XD, et al. Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial. Br J Anaesth. 2023;131(2):253–65.

pubmed: 37474241 doi: 10.1016/j.bja.2023.04.024

Liu Z, Jin Y, Wang L, Huang Z. The Effect of Ciprofol on Postoperative Delirium in Elderly patients undergoing thoracoscopic surgery for Lung Cancer: a prospective, randomized, controlled trial. Drug Des Devel Ther. 2024;18:325–39.

pubmed: 38344256 pmcid: 10857903 doi: 10.2147/DDDT.S441950

Liu F, Lin X, Lin Y, Deng X, Guo Y, Wang B, et al. The effect of neostigmine on postoperative delirium after colon carcinoma surgery: a randomized, double-blind, controlled trial. BMC Anesthesiol. 2022;22(1):267.

pubmed: 35996073 pmcid: 9394039 doi: 10.1186/s12871-022-01804-4

Nagae M, Egi M, Furushima N, Okada M, Makino S, Mizobuchi S. The impact of intravenous isotonic and hypotonic maintenance fluid on the risk of delirium in adult postoperative patients: retrospective before-after observational study. J Anesth. 2019;33(2):287–94.

pubmed: 30806785 doi: 10.1007/s00540-019-02626-4

Wan R, Cai S, Pan D, Yang W, Zhou R. Effects of Atorvastatin Therapy on Postoperative Delirium after Malignant Tumor surgeries in older adults. Neuropsychiatr Dis Treat. 2022;18:915–23.

pubmed: 35469242 pmcid: 9034858 doi: 10.2147/NDT.S360332

Aldecoa C, Bettelli G, Bilotta F, Sanders RD, Audisio R, Borozdina A, et al. European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium. Eur J Anaesthesiol EJA. 2017;34(4):192.

doi: 10.1097/EJA.0000000000000594

Katayama ES, Stecko H, Woldesenbet S, Khalil M, Munir MM, Endo Y et al. The role of Delirium on short- and long-term postoperative outcomes following major gastrointestinal surgery for Cancer. Ann Surg Oncol. 2024.

Gearhart SL, Do EM, Owodunni O, Gabre-Kidan AA, Magnuson T. Loss of independence in older patients after operation for Colorectal Cancer. J Am Coll Surg. 2020;230(4):573–82.

pubmed: 32220448 doi: 10.1016/j.jamcollsurg.2019.12.021

French J, Weber T, Ge B, Litofsky NS. Postoperative delirium in patients after brain tumor surgery. World Neurosurg. 2021;155:e472–9.

pubmed: 34455093 doi: 10.1016/j.wneu.2021.08.089

Brattinga B, Plas M, Spikman JM, Rutgers A, de Haan JJ, van der Wal-Huisman H et al. The link between the early surgery-induced inflammatory response and postoperative cognitive dysfunction in older patients. J Am Geriatr Soc. [cited 2024 May 6];n/a(n/a). https://onlinelibrary.wiley.com/doi/abs/ https://doi.org/10.1111/jgs.18876

Du J, Plas M, Absalom AR, van Leeuwen BL, de Bock GH. The association of preoperative anxiety and depression with neurocognitive disorder following oncological surgery. J Surg Oncol. 2020;121(4):676–87.

pubmed: 31930514 pmcid: 7064888 doi: 10.1002/jso.25836

Kapoor I, Prabhakar H, Mahajan C. Postoperative cognitive dysfunction. Indian J Crit Care Med Peer-Rev off Publ Indian Soc Crit Care Med. 2019;23(Suppl 2):S162–4.

Lemaitre AL, Herbet G, Ng S, Moritz-Gasser S, Duffau H. Cognitive preservation following awake mapping-based neurosurgery for low-grade gliomas: a longitudinal, within-patient design study. Neuro-Oncol. 2022;24(5):781–93.

pubmed: 34850187 doi: 10.1093/neuonc/noab275

Huang HW, Zhang XK, Li HY, Wang YG, Jing B, Chen Y, et al. Higher Grade Glioma increases the risk of postoperative delirium: deficient brain compensation might be a potential mechanism of postoperative delirium. Front Aging Neurosci. 2022;14:822984.

pubmed: 35493935 pmcid: 9045131 doi: 10.3389/fnagi.2022.822984

Guran E, Hu J, Wefel JS, Chung C, Cata JP. Perioperative considerations in patients with chemotherapy-induced cognitive impairment: a narrative review. Br J Anaesth. 2022;129(6):909–22.

pubmed: 36270848 doi: 10.1016/j.bja.2022.08.037

Kahl U, Rademacher C, Harler U, Juilfs N, Pinnschmidt HO, Beck S, et al. Intraoperative impaired cerebrovascular autoregulation and delayed neurocognitive recovery after major oncologic surgery: a secondary analysis of pooled data. J Clin Monit Comput. 2022;36(3):765–73.

pubmed: 33860406 doi: 10.1007/s10877-021-00706-z

Daiello LA, Racine AM, Yun Gou R, Marcantonio ER, Xie Z, Kunze LJ, et al. Postoperative delirium and postoperative cognitive dysfunction: overlap and divergence. Anesthesiology. 2019;131(3):477–91.

pubmed: 31166241 doi: 10.1097/ALN.0000000000002729

Kainz E, Stuff K, Kahl U, Wiessner C, Yu Y, von Breunig F, et al. Impact of postanesthesia care unit delirium on self-reported cognitive function and perceived health status: a prospective observational cohort study. Qual Life Res Int J Qual Life Asp Treat Care Rehabil. 2022;31(8):2397–410.

Wang M, Wang J, Li X, Xu X, Zhao Q, Li Y. A predictive model for postoperative cognitive dysfunction in elderly patients with gastric cancer: a retrospective study. Am J Transl Res. 2022;14(1):679–86.

pubmed: 35173886 pmcid: 8829645

Wu Y, Yu C, Gao F. Risk factors for postoperative cognitive dysfunction in elderly patients undergoing surgery for oral malignancies. Perioper Med Lond Engl. 2023;12(1):42.

doi: 10.1186/s13741-023-00330-2

Stern M, Nieuwenhuijs-Moeke GJ, Absalom A, van Leeuwen B, van der Wal-Huisman H, Plas M, et al. Association between anaesthesia-related factors and postoperative neurocognitive disorder: a post-hoc analysis. BMC Anesthesiol. 2023;23(1):368.

pubmed: 37950163 pmcid: 10636964 doi: 10.1186/s12871-023-02318-3

Zhang J, Zhang X, Yang Y, Zhao J, Yu Y. Correlation Analysis of Serum Vitamin D Levels and postoperative cognitive disorder in Elderly patients with gastrointestinal tumor. Front Psychiatry. 2022;13:893309.

pubmed: 35492737 pmcid: 9051327 doi: 10.3389/fpsyt.2022.893309

Guo F, Han R, Sun L, Zheng L, Wang Y, Yan Y, et al. Effect of transcutaneous electrical acupoint stimulation on postoperative cognitive function in older patients with lung cancer: a randomized, double-blind, placebo-controlled trial. Heliyon. 2023;9(9):e19386.

pubmed: 37809441 pmcid: 10558345 doi: 10.1016/j.heliyon.2023.e19386

Xi L, Fang F, Yuan H, Wang D. Transcutaneous electrical acupoint stimulation for postoperative cognitive dysfunction in geriatric patients with gastrointestinal tumor: a randomized controlled trial. Trials. 2021;22(1):563.

pubmed: 34425851 pmcid: 8383437 doi: 10.1186/s13063-021-05534-9

Zang N, Shen W, Li S, Chen L, Ai Q, Huang W, et al. Sublobar resection reduces the risk of postoperative cognitive dysfunction compared with lobectomy. Eur J Cardio-Thorac Surg off J Eur Assoc Cardio-Thorac Surg. 2023;64(5):ezad319.

doi: 10.1093/ejcts/ezad319

Xu W, Zheng Y, Suo Z, Fei K, Wang Y, Liu C, et al. Effect of dexmedetomidine on postoperative systemic inflammation and recovery in patients undergoing digest tract cancer surgery: a meta-analysis of randomized controlled trials. Front Oncol. 2022;12:970557.

pubmed: 36185178 pmcid: 9518820 doi: 10.3389/fonc.2022.970557

Ma XF, Lv SJ, Wei SQ, Mao BR, Zhao XX, Jiang XQ, et al. Influences of dexmedetomidine on stress responses and postoperative cognitive and coagulation functions in patients undergoing radical gastrectomy under general anesthesia. World J Gastrointest Surg. 2023;15(6):1169–77.

pubmed: 37405107 pmcid: 10315113 doi: 10.4240/wjgs.v15.i6.1169

Wang Z, Shen Z, Wang H, Zhang L, Dong R. Effect of dexmedetomidine on the cognitive function of patients undergoing gastric cancer surgery by regulating the PI3K/AKT signaling pathway. Oncol Lett. 2020;19(2):1151–6.

pubmed: 31966044

Zhang J, Liu G, Zhang F, Fang H, Zhang D, Liu S, et al. Analysis of postoperative cognitive dysfunction and influencing factors of dexmedetomidine anesthesia in elderly patients with colorectal cancer. Oncol Lett. 2019;18(3):3058–64.

pubmed: 31402961 pmcid: 6676718

Liao YQ, Min J, Wu ZX, Hu Z. Comparison of the effects of remimazolam and dexmedetomidine on early postoperative cognitive function in elderly patients with gastric cancer. Front Aging Neurosci. 2023;15:1123089.

pubmed: 37342357 pmcid: 10277633 doi: 10.3389/fnagi.2023.1123089

Kuang Q, Zhong N, Ye C, Zhu X, Wei F. Propofol Versus Remimazolam on cognitive function, Hemodynamics, and Oxygenation during one-lung ventilation in older patients undergoing pulmonary lobectomy: a Randomized Controlled Trial. J Cardiothorac Vasc Anesth. 2023;37(10):1996–2005.

pubmed: 37422336 doi: 10.1053/j.jvca.2023.06.027

Ma J, Wang F, Wang J, Wang P, Dou X, Yao S, et al. The effect of low-dose esketamine on postoperative neurocognitive dysfunction in Elderly patients Undergoing General Anesthesia for gastrointestinal tumors: a Randomized Controlled Trial. Drug Des Devel Ther. 2023;17:1945–57.

pubmed: 37408867 pmcid: 10318106 doi: 10.2147/DDDT.S406568

Zhang J, Jia D, Li W, Li X, Ma Q, Chen X. General anesthesia with S-ketamine improves the early recovery and cognitive function in patients undergoing modified radical mastectomy: a prospective randomized controlled trial. BMC Anesthesiol. 2023;23(1):214.

pubmed: 37340359 pmcid: 10280824 doi: 10.1186/s12871-023-02161-6

Wang YY, Fu HJ. Analgesic effect of ultrasound-guided bilateral transversus abdominis plane block in laparoscopic gastric cancer. World J Gastrointest Surg. 2023;15(10):2171–8.

pubmed: 37969718 pmcid: 10642456 doi: 10.4240/wjgs.v15.i10.2171

Shang Y, Qi F, Zheng Z, Yang G, Fei F, Guo Q, et al. Effect of bilateral paravertebral nerve block on cognitive function in elderly patients undergoing radical gastrectomy for gastric cancer: a prospective randomized double-blind controlled trial. BMC Anesthesiol. 2022;22(1):224.

pubmed: 35840876 pmcid: 9284703 doi: 10.1186/s12871-022-01764-9

M Z YQ. H H, S Z, Y M. Effect of quadratus lumborum block on postoperative cognitive function in elderly patients undergoing laparoscopic radical gastrectomy: a randomized controlled trial. BMC Geriatr. 2021 Apr 9 [cited 2024 Apr 11];21(1). https://pubmed.ncbi.nlm.nih.gov/33836651/

Luo X, Li D. Effects of epidural block anesthesia combined with general anesthesia on inflammatory factors, cognitive function and postoperative pain in patients with lung cancer after thoracoscopic surgery. Am J Transl Res. 2021;13(11):13024–33.

pubmed: 34956520 pmcid: 8661174

Su Y, Pu Y, Zhao Z, Yang X. Influence of combined epidural anesthesia on cognitive function, inflammation and stress response in elderly liver cancer patients undergoing surgery. Oncol Lett. 2020;19(4):2733–8.

pubmed: 32218825 pmcid: 7068239

Yan W, Mao H, Qiu P. Effects of different analgesia regimens on early post-operative cognitive dysfunction in elderly patients undergoing radical resection of cervical carcinoma. Exp Ther Med. 2019;18(2):1465–9.

pubmed: 31363379 pmcid: 6614751

Wang XX, Dai J, Wang Q, Deng HW, Liu Y, He GF, et al. Intravenous lidocaine improves postoperative cognition in patients undergoing laparoscopic colorectal surgery: a randomized, double-blind, controlled study. BMC Anesthesiol. 2023;23(1):243.

pubmed: 37474933 pmcid: 10360258 doi: 10.1186/s12871-023-02210-0

Sun H, Zhang G, Ai B, Zhang H, Kong X, Lee WT, et al. A systematic review: comparative analysis of the effects of propofol and sevoflurane on postoperative cognitive function in elderly patients with lung cancer. BMC Cancer. 2019;19(1):1248.

pubmed: 31870348 pmcid: 6929352 doi: 10.1186/s12885-019-6426-2

Li Y, Zhang B. Effects of anesthesia depth on postoperative cognitive function and inflammation: a systematic review and meta-analysis. Minerva Anestesiol. 2020;86(9):965–73.

pubmed: 32251571 doi: 10.23736/S0375-9393.20.14251-2

Shi X, Chen X, Ni J, Zhang Y, Liu H, Xu C, et al. Systematic review and meta-analysis of the prognostic value of Narcotrend monitoring of different depths of anesthesia and different Bispectral Index (BIS) values for cognitive dysfunction after tumor surgery in elderly patients. Ann Transl Med. 2022;10(4):186.

pubmed: 35280411 pmcid: 8908161 doi: 10.21037/atm-22-90

Laferrière-Langlois P, Morisson L, Jeffries S, Duclos C, Espitalier F, Richebé P. Depth of Anesthesia and Nociception Monitoring: current state and vision for 2050. Anesth Analg. 2024;138(2):295–307.

pubmed: 38215709 doi: 10.1213/ANE.0000000000006860

Kahl U, Callsen S, Beck S, Pinnschmidt H, von Breunig F, Haese A, et al. Health-related quality of life and self-reported cognitive function in patients with delayed neurocognitive recovery after radical prostatectomy: a prospective follow-up study. Health Qual Life Outcomes. 2021;19(1):64.

pubmed: 33632235 pmcid: 7908756 doi: 10.1186/s12955-021-01705-z