Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function.

CP: Immunology CP: Molecular biology DC development IRF IRF8 KDM5C antigen presentation dendritic cells epigenetics histone demethylase interferon metabolism

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
23 Jul 2024
Historique:
received: 06 11 2023
revised: 30 03 2024
accepted: 27 06 2024
medline: 26 7 2024
pubmed: 26 7 2024
entrez: 25 7 2024
Statut: aheadofprint

Résumé

Functional and phenotypic heterogeneity of dendritic cells (DCs) play crucial roles in facilitating the development of diverse immune responses essential for host protection. Here, we report that KDM5C, a histone lysine demethylase, regulates conventional or classical DC (cDC) and plasmacytoid DC (pDC) population heterogeneity and function. Mice deficient in KDM5C in DCs have increased proportions of cDC2Bs and cDC1s, which is partly dependent on type I interferon (IFN) and pDCs. Loss of KDM5C results in an increase in Ly6C

Identifiants

DOI: 10.1016/j.celrep.2024.114506 PMID: 39052479
pubmed: 39052479
pii: S2211-1247(24)00835-0
doi: 10.1016/j.celrep.2024.114506
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114506

Informations de copyright

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Hannah Guak (H)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.

Matthew Weiland (M)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.

Alexandra Vander Ark (AV)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.

Lukai Zhai (L)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.

Kin Lau (K)

Bioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI 49503, USA.

Mario Corrado (M)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA; Department of Internal Medicine, University of Toronto, Toronto, ON M5S 3H2, Canada.

Paula Davidson (P)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.

Ebenezer Asiedu (E)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.

Batsirai Mabvakure (B)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA; Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA; Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

Shelby Compton (S)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.

Lisa DeCamp (L)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.

Catherine A Scullion (CA)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA; Department of Experimental Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Russell G Jones (RG)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.

Sara M Nowinski (SM)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.

Connie M Krawczyk (CM)

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: connie.krawczyk@vai.org.

Classifications MeSH