Cumulative Detection of Anal High-Grade Squamous Intraepithelial Lesions Over 2-Year Follow-up in Men Who Have Sex With Men Living With Human Immunodeficiency Virus in France.
Humans
Male
HIV Infections
/ complications
Squamous Intraepithelial Lesions
/ virology
Homosexuality, Male
France
/ epidemiology
Adult
Anus Neoplasms
/ virology
Middle Aged
Papillomavirus Infections
/ virology
Follow-Up Studies
Anal Canal
/ virology
Human papillomavirus 16
/ isolation & purification
Sexual and Gender Minorities
anal cytology
high-resolution anoscopy
human immunodeficiency virus
human papillomavirus
men who have sex with men
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
25 Jul 2024
25 Jul 2024
Historique:
received:
05
06
2023
accepted:
14
11
2023
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
ppublish
Résumé
We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSILs) in men who have sex with men living with human immunodeficiency virus and who underwent 3 visits over 2 years, with cytology and high-resolution anoscopy, within the ANRS-EP57-APACHES study. The cumulative HSIL detection rate was 33% (134 of 410), of which 48% HSILs were detected at baseline. HSIL detection varied considerably by center (from 13% to 51%). The strongest HSIL determinants were baseline human papillomavirus 16 (adjusted odds ratio, 8.2; 95% confidence interval, 3.6-18.9) and p16/Ki67 (4.6 [2.3-9.1]). Repeated annual cytology and high-resolution anoscopy improved HSIL detection but did not fully compensate for between-center heterogeneity.
Identifiants
pubmed: 39052708
pii: 7720834
doi: 10.1093/infdis/jiad506
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-60Subventions
Organisme : ANRS
Organisme : France Recherche Nord et Sud SIDA-HIV Hépatites
ID : 14730
Investigateurs
Cédric Arvieux
(C)
Ana Canestri
(A)
Gary Clifford
(G)
Jean-Damien Combes
(JD)
Valérie Costes-Martineau
(V)
Jean Del Grande
(J)
Jean-Michel Didelot
(JM)
Isabelle Etienney
(I)
Michael Falguières
(M)
Tristan Ferry
(T)
Hugues Fischer
(H)
Jean-Francois Flejou
(JF)
Isabelle Heard
(I)
Sébastien Henno
(S)
Nadia Hoyau
(N)
Marine Landon
(M)
Hélène Laude
(H)
Frédérique Le Breton
(F)
Anne-Carole Lesage
(AC)
Annie Lion
(A)
Gilles Maincent
(G)
Lucie Marchand
(L)
Haingo Njatonirina Andrianiaina
(HN)
Olivier Patey
(O)
Ventzislava Petrov Sanchez
(VP)
Gilles Pialoux
(G)
Marion Pirel
(M)
Lionel Piroth
(L)
Isabelle Poizot-Martin
(I)
Sylvie Radenne
(S)
Emmanuelle Ressiot
(E)
Jacques Reynes
(J)
Laurent Siproudhis
(L)
Catherine Tamalet
(C)
Pierre Tattevin
(P)
Olivia Zaegel-Faucher
(O)
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Déclaration de conflit d'intérêts
Potential conflicts of interest. O. Z. F. received honoraria from Gilead for a presentation after the 2023 Conference on Retroviruses and Opportunistic Infections, as well as support from ViiV Healthcare for traveling to and attending the European AIDS Conference in October 2023 and the Société Française de Lutte contre le Sida conference in 2022. T. M. D. received grants/contracts from the U.S. National Cancer Institute for the ANCHOR study, central pathology review, and salary support to the University of California, San Francisco. C. J. A.'s employer received an unrestricted research grant from GSK for an investigator-initiated research project not related to this work. I. E. has received payment or honoraria from Merck Sharp & Dohme for an educational event for practitioners. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.