Tolerance thresholds underlie responses to DNA damage during germline development.
CRISPR–Cas9
DNA damage
Drosophila melanogaster
P-element
double-strand break
genome integrity
germline development
hybrid dysgenesis
meiosis
transposable element
Journal
Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660
Informations de publication
Date de publication:
25 Jul 2024
25 Jul 2024
Historique:
received:
11
04
2024
accepted:
05
07
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
aheadofprint
Résumé
Selfish DNA modules like transposable elements (TEs) are particularly active in the germline, the lineage that passes genetic information across generations. New TE insertions can disrupt genes and impair the functionality and viability of germ cells. However, we found that in
Identifiants
pubmed: 39054057
pii: gad.351701.124
doi: 10.1101/gad.351701.124
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 Jansen et al.; Published by Cold Spring Harbor Laboratory Press.