Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism.
Cytochrome P450 (CYP)
Drug development
cytochrome P450
cytochrome P450 function
drug clearance
drug metabolism
drug toxicity
drug-drug interactions
Journal
Pharmacological reviews
ISSN: 1521-0081
Titre abrégé: Pharmacol Rev
Pays: United States
ID NLM: 0421737
Informations de publication
Date de publication:
25 Jul 2024
25 Jul 2024
Historique:
accepted:
22
07
2024
received:
26
03
2024
revised:
28
05
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
aheadofprint
Résumé
Our knowledge of the roles of individual cytochrome P450 (P450, CYP) enzymes in drug metabolism has developed considerably in the past 30 years, and this base has been of considerable use in avoiding serious issues with drug interactions and issues due to variations. Some newer approaches are being considered for "phenotyping" of metabolism reactions with new drug candidates. Endogenous biomarkers are being used for non-invasive estimation of levels of individual P450 enzymes. There is also the matter of some remaining "orphan" P450s, which have yet to be assigned reactions. Practical problems that continue in drug development include predicting drug-drug interactions, predicting the effects of polymorphic and other P450 variations, and evaluating inter-species differences in drug metabolism, particularly in the context of "metabolism in safety testing" (MIST) regulatory issues ("disproportionate (human) metabolites").
Identifiants
pubmed: 39054072
pii: pharmrev.124.001173
doi: 10.1124/pharmrev.124.001173
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 American Society for Pharmacology and Experimental Therapeutics.