Impact of early palliative care intervention in autologous bone marrow transplantation: feasibility of a multicentric study.
Autologous haematopoietic stem cell transplantation
Palliate care intervention
Quality of life
Journal
BMC palliative care
ISSN: 1472-684X
Titre abrégé: BMC Palliat Care
Pays: England
ID NLM: 101088685
Informations de publication
Date de publication:
25 Jul 2024
25 Jul 2024
Historique:
received:
25
04
2024
accepted:
01
07
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
epublish
Résumé
This prospective multicentre study evaluates the impact of Palliative Care Unit (PCU) intervention (Experimental Group, EG), during autologous hematopoietic stem cell transplantation (AHSCT) on quality of life (QoL), symptom control and healthcare resource use compared to standard practice (Control Group, CG). We used validated scales on Days 0 (stem cell infusion), + 7 (bone marrow aplasia, acute symptoms) and + 21 (aplasia recovery). In 40 patients (20 EG/ 20 CG: 45%/25% female, median age 57.5/59), QoL differed significantly at Day + 7 (EG: median 0.50; CG: -63.00; p < 0.001) and Day + 21 (EG: -2.00; CG: -129.00; p < 0.001). On Day 0, mean FACT-BMT scores were CG/EG: 131/ 89.35, reflecting the pre-transplant intervention of the PCU in EG patients. For pain (EG median 0.00, CG median 2.50; p = 0.01), 45% EG patients used opioids on day 0 (mean 38.5 mg morphine/day/patient). Reduced pain control impacted nutritional support (parenteral nutrition 45% CG, 5% EG; p = 0.08). Hospitalisation duration was longer in CG (median 18.5; EG median 13.00; p < 0.001). Despite the short follow-up and small sample size, PCU and HD collaboration improves QoL and symptom management during acute AHSCT, evident through pain control, analgesia management, reduced parenteral nutrition need and shorter hospital stays.
Identifiants
pubmed: 39054470
doi: 10.1186/s12904-024-01499-z
pii: 10.1186/s12904-024-01499-z
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
186Subventions
Organisme : Fundación de Investigación del Hospital Príncipe de Asturias de Alcalá de Henares
ID : FIB-PI22-01
Organisme : Fundación de Investigación del Hospital Príncipe de Asturias de Alcalá de Henares
ID : FIB-PI22-01
Organisme : Fundación de Investigación del Hospital Príncipe de Asturias de Alcalá de Henares
ID : FIB-PI22-01
Informations de copyright
© 2024. The Author(s).
Références
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