Effects of mind-body interventions on polycystic ovary syndrome: a comprehensive meta-analysis.

Polycystic Ovary Syndrome / therapy Humans Female Mind-Body Therapies / methods Quality of Life Randomized Controlled Trials as Topic Treatment Outcome
Endocrine and glycolipid metabolism Meta-analysis Mind-body interventions Polycystic ovary syndrome Randomized controlled trial

Journal

Journal of ovarian research
ISSN: 1757-2215
Titre abrégé: J Ovarian Res
Pays: England
ID NLM: 101474849

Informations de publication

Date de publication:
25 Jul 2024
Historique:
received: 17 06 2024
accepted: 15 07 2024
medline: 26 7 2024
pubmed: 26 7 2024
entrez: 25 7 2024
Statut: epublish

Résumé

Mind-body interventions (MBI) have emerged as a potential therapeutic approach, but their effectiveness in the treatment of Polycystic Ovary Syndrome (PCOS) remains inconclusive. This study systematically evaluates the effectiveness of MBI on quality of life, anthropometry, androgen secretion, glucose, and lipid metabolism in PCOS. A computer search was conducted across three databases: PubMed, the Cochrane Library, and EMBASE, to identify randomized controlled trials (RCTs) related to MBI for PCOS from their inception until July 2024. DerSimonian and Laird's random-effects model and Stata 17.0 software was employed for our meta-analysis. Twelve RCTs were included. MBI significantly improved PCOSQ subscale scores, including emotional disturbances (MD: 7.75, 95% CI: 6.10 to 9.40), body hair (MD: 2.73, 95% CI: 0.54 to 4.91), menstrual problems (MD: 3.79, 95% CI: 2.89 to 4.69), and weight (MD: 1.48, 95% CI: 0.03 to 2.93). Furthermore, there was a reduction in depression levels (MD: -1.53, 95% CI: -2.93 to -0.13). Sensitivity analysis confirmed the robustness of PCOSQ-Emotional disturbances and PCOSQ-Menstrual problems, with a high GRADE level of evidence for these subscales. Secondary outcome measures, including waist-hip ratio, fasting blood glucose, and HOMA-IR exhibited statistically significant differences. Subgroup analysis revealed that obesity could influence treatment outcomes. MBI can serve as an alternative therapy, modulating effect on the quality of life and depression in PCOS patients. Future well-designed, high-quality, and large-scale studies should be conducted to thoroughly assess the impact of different Mind-Body Interventions (MBI) on various PCOS phenotypes. PROSPERO (CRD42023472035).

Sections du résumé

BACKGROUND BACKGROUND
Mind-body interventions (MBI) have emerged as a potential therapeutic approach, but their effectiveness in the treatment of Polycystic Ovary Syndrome (PCOS) remains inconclusive. This study systematically evaluates the effectiveness of MBI on quality of life, anthropometry, androgen secretion, glucose, and lipid metabolism in PCOS.
METHODS METHODS
A computer search was conducted across three databases: PubMed, the Cochrane Library, and EMBASE, to identify randomized controlled trials (RCTs) related to MBI for PCOS from their inception until July 2024. DerSimonian and Laird's random-effects model and Stata 17.0 software was employed for our meta-analysis.
RESULTS RESULTS
Twelve RCTs were included. MBI significantly improved PCOSQ subscale scores, including emotional disturbances (MD: 7.75, 95% CI: 6.10 to 9.40), body hair (MD: 2.73, 95% CI: 0.54 to 4.91), menstrual problems (MD: 3.79, 95% CI: 2.89 to 4.69), and weight (MD: 1.48, 95% CI: 0.03 to 2.93). Furthermore, there was a reduction in depression levels (MD: -1.53, 95% CI: -2.93 to -0.13). Sensitivity analysis confirmed the robustness of PCOSQ-Emotional disturbances and PCOSQ-Menstrual problems, with a high GRADE level of evidence for these subscales. Secondary outcome measures, including waist-hip ratio, fasting blood glucose, and HOMA-IR exhibited statistically significant differences. Subgroup analysis revealed that obesity could influence treatment outcomes.
CONCLUSION CONCLUSIONS
MBI can serve as an alternative therapy, modulating effect on the quality of life and depression in PCOS patients. Future well-designed, high-quality, and large-scale studies should be conducted to thoroughly assess the impact of different Mind-Body Interventions (MBI) on various PCOS phenotypes.
TRIAL REGISTRATION BACKGROUND
PROSPERO (CRD42023472035).

Identifiants

DOI: 10.1186/s13048-024-01477-2 PMID: 39054488
pubmed: 39054488
doi: 10.1186/s13048-024-01477-2
pii: 10.1186/s13048-024-01477-2
doi:

Types de publication

Journal Article Meta-Analysis

Langues

eng

Sous-ensembles de citation

IM

Pagination

154

Informations de copyright

© 2024. The Author(s).

Références

Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, et al. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 2022;10(9):668–80.
pubmed: 35934017 doi: 10.1016/S2213-8587(22)00163-2
Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270–84.
pubmed: 29569621 doi: 10.1038/nrendo.2018.24
Anagnostis P, Tarlatzis BC, Kauffman RP. Polycystic ovarian syndrome (PCOS): long-term metabolic consequences. Metabolism. 2018;86:33–43.
pubmed: 29024702 doi: 10.1016/j.metabol.2017.09.016
Xu Y, Qiao J. Association of Insulin Resistance and elevated androgen levels with polycystic ovarian syndrome (PCOS): a review of literature. J Healthc Eng. 2022;2022:9240569.
pubmed: 35356614 pmcid: 8959968 doi: 10.1155/2022/9240569
Azziz R. Polycystic ovary syndrome. Obstet Gynecol. 2018;132(2):321–36.
pubmed: 29995717 doi: 10.1097/AOG.0000000000002698
Teede H, Deeks A, Moran L. Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med. 2010;8:41.
pubmed: 20591140 pmcid: 2909929 doi: 10.1186/1741-7015-8-41
Deeks AA, Gibson-Helm ME, Teede HJ. Anxiety and depression in polycystic ovary syndrome: a comprehensive investigation. Fertil Steril. 2010;93(7):2421–3.
pubmed: 20117778 doi: 10.1016/j.fertnstert.2009.09.018
Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018;110(3):364–79.
pubmed: 30033227 pmcid: 6939856 doi: 10.1016/j.fertnstert.2018.05.004
Zarezadeh M, Musazadeh V, Foroumandi E, Keramati M, Ostadrahimi A, Mekary RA. The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes or with polycystic ovary syndrome: an umbrella meta-analysis on interventional meta-analyses. Diabetol Metab Syndr. 2023;15(1):127.
pubmed: 37316893 pmcid: 10268424 doi: 10.1186/s13098-023-01057-2
Abbasi S, Mashatan N, Farmani E, Khodashenas M, Musazadeh V, Ahrabi SS, et al. The effects of purslane (Portulaca oleracea) on glycemic indices: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2023;37(12):5529–40.
pubmed: 37661794 doi: 10.1002/ptr.7997
Musazadeh V, Mohammadi Anilou M, Vajdi M, Karimi A, Sedgh Ahrabi S, Dehghan P. Effects of synbiotics supplementation on anthropometric and lipid profile parameters: finding from an umbrella meta-analysis. Front Nutr. 2023;10:1121541.
pubmed: 36908920 pmcid: 9995782 doi: 10.3389/fnut.2023.1121541
Lim SS, Hutchison SK, Van Ryswyk E, Norman RJ, Teede HJ, Moran LJ. Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2019;3(3):CD007506.
pubmed: 30921477
Hoeger KM, Dokras A, Piltonen T. Update on PCOS: consequences, challenges, and Guiding Treatment. J Clin Endocrinol Metab. 2021;106(3):e1071–83.
pubmed: 33211867 doi: 10.1210/clinem/dgaa839
Dema H, Videtič Paska A, Kouter K, Katrašnik M, Jensterle M, Janež A, et al. Effects of Mindfulness-based therapy on clinical symptoms and DNA methylation in patients with polycystic ovary syndrome and high metabolic risk. Curr Issues Mol Biol. 2023;45(4):2717–37.
pubmed: 37185702 pmcid: 10136994 doi: 10.3390/cimb45040178
Rao V, Pena A, James A, Phadke A, Grover J, Blendis E, et al. The role of meditation and mindfulness in the management of polycystic ovary syndrome: a scoping review. Front Endocrinol (Lausanne). 2024;15:1295705.
pubmed: 38818503 doi: 10.3389/fendo.2024.1295705
Wahbeh H, Elsas SM, Oken BS. Mind-body interventions: applications in neurology. Neurology. 2008;70(24):2321–8.
pubmed: 18541886 doi: 10.1212/01.wnl.0000314667.16386.5e
Love MF, Sharrief A, Chaoul A, Savitz S, Beauchamp JES. Mind-body interventions, psychological stressors, and Quality of Life in Stroke survivors. Stroke. 2019;50(2):434–40.
pubmed: 30612536 doi: 10.1161/STROKEAHA.118.021150
Caplin A, Chen FS, Beauchamp MR, Puterman E. The effects of exercise intensity on the cortisol response to a subsequent acute psychosocial stressor. Psychoneuroendocrinology. 2021;131:105336.
pubmed: 34175558 doi: 10.1016/j.psyneuen.2021.105336
Verma A, Upadhyay V, Saxena V. Effect of yoga therapy on Health outcomes in Women with Polycystic Ovary Syndrome: a systematic review and Meta-analysis. Am J Lifestyle Med. 2023;17(1):73–92.
pubmed: 36636398 doi: 10.1177/15598276211029221
Li Y, Peng C, Zhang M, Xie L, Gao J, Wang Y, et al. Tai Chi for Overweight/Obese adolescents and young women with polycystic ovary syndrome: a Randomized Controlled Pilot Trial. Evid Based Complement Alternat Med. 2022;2022:4291477.
pubmed: 35754690 pmcid: 9232331
Majidzadeh S, Mirghafourvand M, Farvareshi M, Yavarikia P. The effect of cognitive behavioral therapy on depression and anxiety of women with polycystic ovary syndrome: a randomized controlled trial. BMC Psychiatry. 2023;23(1):332.
pubmed: 37170227 pmcid: 10174601 doi: 10.1186/s12888-023-04814-9
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. J Clin Epidemiol. 2021;134:178–89.
pubmed: 33789819 doi: 10.1016/j.jclinepi.2021.03.001
Evidence-based methodology workshop on polycystic ovary syndrome,2012. Executive summary. https://prevention.nih.gov/sites/default/files/2018-06/FinalReport.pdf . Accessed October 12, 2023.
Rotterdam E. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19–25.
doi: 10.1016/j.fertnstert.2003.10.004
Cronin L, Guyatt G, Griffith L, Wong E, Azziz R, Futterweit W, et al. Development of a health-related quality-of-life questionnaire (PCOSQ) for women with polycystic ovary syndrome (PCOS). J Clin Endocrinol Metab. 1998;83(6):1976–87.
pubmed: 9626128
Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions. 2008.
Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64(4):383–94.
pubmed: 21195583 doi: 10.1016/j.jclinepi.2010.04.026
Roessler KK, Glintborg D, Ravn P, Birkebaek C, Andersen M. Supportive relationships–psychological effects of group counselling in women with polycystic ovary syndrome (PCOS). Commun Med. 2012;9(2):125–31.
pubmed: 24498697 doi: 10.1558/cam.v9i2.125
Jiskoot G, Dietz de Loos A, Beerthuizen A, Timman R, Busschbach J, Laven J. Long-term effects of a three-component lifestyle intervention on emotional well-being in women with polycystic ovary syndrome (PCOS): a secondary analysis of a randomized controlled trial. PLoS ONE. 2020;15(6):e0233876.
pubmed: 32479544 pmcid: 7263605 doi: 10.1371/journal.pone.0233876
Jiskoot G, Timman R, Beerthuizen A, Dietz de Loos A, Busschbach J, Laven J. Weight reduction through a cognitive behavioral therapy lifestyle intervention in PCOS: the primary outcome of a Randomized Controlled Trial. Obes (Silver Spring Md). 2020;28(11):2134–41.
doi: 10.1002/oby.22980
Shalini B, Elangovan R. Efficacy of yoga therapy on body mass index and testosterone among adult women with polycystic ovarian syndrome. Eur J Mol Clin Med. 2020;7(9):1103–9.
doi: 10.31838/ejmcm.07.09.114
Bahrami H, Mohseni M, Amini L, Karimian Z. The effect of six weeks yoga exercises on quality of life in infertile women with polycystic ovary syndrome (Pcos). Iran J Obstet Gynecol Infertility. 2019;22(5):18–26.
Roessler KK, Birkebaek C, Ravn P, Andersen MS, Glintborg D. Effects of exercise and group counselling on body composition and VO2max in overweight women with polycystic ovary syndrome. Acta Obstet Gynecol Scand. 2013;92(3):272–7.
pubmed: 23237575 doi: 10.1111/aogs.12064
Moradi F, Ghadiri-Anari A, Dehghani A, Vaziri SR, Enjezab B. The effectiveness of counseling based on acceptance and commitment therapy on body image and self-esteem in polycystic ovary syndrome: an RCT. Int J Reproductive Biomed. 2020;18(4):243–52.
Abdollahi L, Mirghafourvand M, Babapour JK, Mohammadi M. Effectiveness of cognitive-behavioral therapy (CBT) in improving the quality of life and psychological fatigue in women with polycystic ovarian syndrome: a randomized controlled clinical trial. J Psychosom Obstet Gynaecol. 2019;40(4):283–93.
pubmed: 30175648 doi: 10.1080/0167482X.2018.1502265
Nidhi RPV, Nagarathna R, Ram A. Effect of a yoga program on glucose metabolism and blood lipid levels in adolescent girls with polycystic ovary syndrome. Int J Gynaecol Obstet. 2012;118(1):37–41.
pubmed: 22507264 doi: 10.1016/j.ijgo.2012.01.027
Nidhi RPV, Nagarathna R, Ram A. Effect of holistic yoga program on anxiety symptoms in adolescent girls with polycystic ovarian syndrome: a randomized control trial. Int J Yoga. 2012;5(2):112–7.
pubmed: 22869994 doi: 10.4103/0973-6131.98223
Nidhi RPV, Nagarathna R, Ram A. Effects of a holistic yoga program on endocrine parameters in adolescents with polycystic ovarian syndrome: a randomized controlled trial. J Altern Complement Med. 2013;19(2):153–60.
pubmed: 22808940 doi: 10.1089/acm.2011.0868
Nidhi RPV, Nagarathna R, Ram A. Effect of yoga program on quality of life in adolescent polycystic ovarian syndrome: a Randomized Control Trial. Appl Res Qual Life. 2013;8:373–83.
doi: 10.1007/s11482-012-9191-9
Stefanaki C, Bacopoulou F, Livadas S, Kandaraki A, Karachalios A, Chrousos GP, et al. Impact of a mindfulness stress management program on stress, anxiety, depression and quality of life in women with polycystic ovary syndrome: a randomized controlled trial. Stress. 2015;18(1):57–66.
pubmed: 25287137 doi: 10.3109/10253890.2014.974030
Cooney LG, Milman LW, Hantsoo L, Kornfield S, Sammel MD, Allison KC, et al. Cognitive-behavioral therapy improves weight loss and quality of life in women with polycystic ovary syndrome: a pilot randomized clinical trial. Fertil Steril. 2018;110(1):161–e711.
pubmed: 29908771 pmcid: 6443091 doi: 10.1016/j.fertnstert.2018.03.028
Moeller LV, Lindhardt CL, Andersen MS, Glintborg D, Ravn P. Motivational interviewing in obese women with polycystic ovary syndrome - a pilot study. Gynecol Endocrinol. 2019;35(1):76–80.
pubmed: 30182773 doi: 10.1080/09513590.2018.1498832
Patel V, Menezes H, Menezes C, Bouwer S, Bostick-Smith CA, Speelman DL. Regular mindful yoga practice as a method to improve androgen levels in women with polycystic ovary syndrome: a Randomized, Controlled Trial. J Am Osteopath Assoc. 2020.
Mohseni M, Eghbali M, Bahrami H, Dastaran F, Amini L. Yoga effects on Anthropometric indices and polycystic ovary syndrome symptoms in women undergoing infertility treatment: a Randomized Controlled Clinical Trial. Evid Based Complement Alternat Med. 2021;2021:5564824.
pubmed: 34221076 pmcid: 8213483 doi: 10.1155/2021/5564824
Yin MXC, Du LB, Zou XN, Fung YL, Sun YY, Chan CHY, et al. Can psychosocial intervention suppress testosterone and triglycerides among women with polycystic ovary syndrome? A feasibility trial. Front Psychol. 2021;12:690539.
pubmed: 34367014 pmcid: 8339270 doi: 10.3389/fpsyg.2021.690539
Garland EL, Brintz CE, Hanley AW, Roseen EJ, Atchley RM, Gaylord SA, et al. Mind-body therapies for opioid-treated Pain: a systematic review and Meta-analysis. JAMA Intern Med. 2020;180(1):91–105.
pubmed: 31682676 doi: 10.1001/jamainternmed.2019.4917
Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, hip, and Knee. Arthritis Care Res. 2020;72(2):149–62.
doi: 10.1002/acr.24131
Jiskoot G, van der Kooi AL, Busschbach J, Laven J, Beerthuizen A. Cognitive behavioural therapy for depression in women with PCOS: systematic review and meta-analysis. Reprod Biomed Online. 2022;45(3):599–607.
pubmed: 35810080 doi: 10.1016/j.rbmo.2022.05.001
Diamanti-Kandarakis E, Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev. 2012;33(6):981–1030.
pubmed: 23065822 pmcid: 5393155 doi: 10.1210/er.2011-1034
Kogure GS, Ribeiro VB, Lopes IP, Furtado CLM, Kodato S, Silva de Sá MF, et al. Body image and its relationships with sexual functioning, anxiety, and depression in women with polycystic ovary syndrome. J Affect Disord. 2019;253:385–93.
pubmed: 31082731 doi: 10.1016/j.jad.2019.05.006
Franik G, Bizoń A, Włoch S, Pluta D, Blukacz Ł, Milnerowicz H, et al. The effect of abdominal obesity in patients with polycystic ovary syndrome on metabolic parameters. Eur Rev Med Pharmacol Sci. 2017;21(21):4755–61.
pubmed: 29164590
Cena H, Chiovato L, Nappi RE, Obesity. Polycystic ovary syndrome, and infertility: a New Avenue for GLP-1 receptor agonists. J Clin Endocrinol Metab. 2020;105(8):e2695–709.
pubmed: 32442310 pmcid: 7457958 doi: 10.1210/clinem/dgaa285
Dewailly D, Robin G, Peigne M, Decanter C, Pigny P, Catteau-Jonard S. Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary. Hum Reprod Update. 2016;22(6):709–24.
pubmed: 27566840 doi: 10.1093/humupd/dmw027
Moher D, Hopewell S, Schulz KF, Montori V, Gøtzsche PC, Devereaux PJ, et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol. 2010;63(8):e1–37.
pubmed: 20346624 doi: 10.1016/j.jclinepi.2010.03.004

Auteurs

Kun Zhao (K)

Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou, Zhejiang, 310014, China.

Liuyan Nie (L)

Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Xiangming Ye (X)

Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou, Zhejiang, 310014, China.

Xiaoyan Hu (X)

Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou, Zhejiang, 310014, China. 1150438953@qq.com.

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Classifications MeSH

questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Kystes de l'ovaire › Syndrome des ovaires polykystiques › Effects of mind-body interventions on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effects of mind-body interventions on...
questionsmedicales.fr › Thérapeutique › Thérapies complémentaires › Thérapies corps-esprit › Effects of mind-body interventions on...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Effects of mind-body interventions on...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Effects of mind-body interventions on...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Effects of mind-body interventions on...