Ultrasonographic abnormalities in clinically unaffected nerves of patients with nonvasculitic motor and sensorimotor mononeuropathies.
electrodiagnosis
inflammatory mononeuropathy
nerve cross‐sectional area
peripheral nerves
ultrasonography
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
26 Jul 2024
26 Jul 2024
Historique:
revised:
16
07
2024
received:
22
01
2024
accepted:
17
07
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
26
7
2024
Statut:
aheadofprint
Résumé
Diagnostic criteria for multifocal motor neuropathy (MMN) and multifocal acquired demyelinating sensorimotor neuropathy (MADSAM) require the involvement of at least two peripheral nerves. However, many patients with very similar features have clinical involvement of only a single peripheral nerve, which may preclude their correct diagnosis and treatment. The present study aimed to present a cohort of such patients and discuss the role of ultrasonography (US) in their diagnosis. Patients with nonvasculitic immune-mediated motor mononeuropathies (MM) and sensorimotor mononeuropathies (SMM) were recruited prospectively or identified from the electronic records. They were invited to comprehensive follow-up visits consisting of clinical examination, electrodiagnostic (EDx), and US studies. Twenty-four patients (13 men) were studied (11 with MM). The characteristics of MM and SMM patients were very similar to MMN and MADSAM, respectively. The US, in addition to a long-swollen segment (average length, 20 cm) in the clinically affected nerve, revealed nerve swelling in, on average, six additional sites in clinically unaffected nerves. In patients with clinical and EDx involvement of only a single nerve, an US demonstration of multifocal peripheral nerve swelling points to a more widespread, probably dysimmune mechanism. Further studies are needed to evaluate the value of US as a supplementary method for the diagnosis of MADSAM and MMN in patients with clinical involvement of a single nerve.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Republic of Slovenia Research Agency
ID : P3-0338
Informations de copyright
© 2024 Wiley Periodicals LLC.
Références
Van den Bergh PYK, van Doorn PA. European academy of neurology/peripheral nerve society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force‐second revision. J Peripher Nerv Syst. 2021;26:242‐268.
Joint Task Force of the EFNS and the PNS. European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of multifocal motor neuropathy. Report of a Joint Task Force of the European Federation of Neurological Societies and the Peripheral Nerve Society—first revision. J Peripher Nerv Syst. 2010;15:295‐301.
Grimm A, Decard BF, Bischof A, Axer H. Ultrasound of the peripheral nerves in systemic vasculitic neuropathies. J Neurol Sci. 2014;347:44‐49.
ArÁnyi Z, Csillik A, DéVay K, et al. Ultrasonography in neuralgic amyotrophy: sensitivity, spectrum of findings, and clinical correlations. Muscle Nerve. 2017;56:1054‐1062.
O'Brien M. Aids to the Examination of the Peripheral Nervous System. Saunders Ltd.; 2010.
Omejec G, Podnar S. Precise localization of ulnar neuropathy at the elbow. Clin Neurophysiol. 2015;126:2390‐2396.
Podnar S, Sarafov S, Tournev I, Omejec G, Zidar J. Peripheral nerve ultrasonography in patients with transthyretin amyloidosis. Clin Neurophysiol. 2017;128:505‐511.
Statistics Kingdom. Statistics online. Volume 2024. 2017 https://www.statskingdom.com/index.html
Beekman R, van den Berg LH, Franssen H, Visser LH, van Asseldonk JT, Wokke JH. Ultrasonography shows extensive nerve enlargements in multifocal motor neuropathy. Neurology. 2005;65:305‐307.
van Rosmalen M, Lieba‐Samal D, Pillen S, van Alfen N. Ultrasound of peripheral nerves in neuralgic amyotrophy. Muscle Nerve. 2019;59:55‐59.
Kerasnoudis A, Pitarokoili K, Behrendt V, Gold R, Yoon MS. Nerve ultrasound score in distinguishing chronic from acute inflammatory demyelinating polyneuropathy. Clin Neurophysiol. 2014;125:635‐641.
Kerasnoudis A, Pitarokoili K, Behrendt V, Gold R, Yoon MS. Multifocal motor neuropathy: correlation of nerve ultrasound, electrophysiological, and clinical findings. J Peripher Nerv Syst. 2014;19:165‐174.
Goedee HS, van der Pol WL, van Asseldonk JH, et al. Diagnostic value of sonography in treatment‐naive chronic inflammatory neuropathies. Neurology. 2017;88:143‐151.
Taylor BV, Wright RA, Harper CM, Dyck PJ. Natural history of 46 patients with multifocal motor neuropathy with conduction block. Muscle Nerve. 2000;23:900‐908.
Viala K, Renié L, Maisonobe T, et al. Follow‐up study and response to treatment in 23 patients with Lewis‐Sumner syndrome. Brain. 2004;127:2010‐2017.
Scheidl E, Bohm J, Farbaky Z, Simo M, Bereczki D, Aranyi Z. Ultrasonography of ulnar neuropathy at the elbow: axonal involvement leads to greater nerve swelling than demyelinating nerve lesion. Clin Neurophysiol. 2013;124:619‐625.
Breiner A, Ebadi H, Bril V, Barnett C, Katzberg HD. Ultrasound in multifocal motor neuropathy: clinical and electrophysiological correlations. J Clin Neuromuscul Dis. 2019;20:165‐172.
Herraets IJT, Goedee HS, Telleman JA, et al. Nerve ultrasound improves detection of treatment‐responsive chronic inflammatory neuropathies. Neurology. 2020;94:e1470‐e1479.
Thompson AJ, Banwell BL, Barkhof F, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17:162‐173.
Verschueren A, Azulay JP, Attarian S, Boucraut J, Pellissier JF, Pouget J. Lewis‐Sumner syndrome and multifocal motor neuropathy. Muscle Nerve. 2005;31:88‐94.
Van Asseldonk JT, Franssen H, Van den Berg‐Vos RM, Wokke JH, Van den Berg LH. Multifocal motor neuropathy. Lancet Neurol. 2005;4:309‐319.
Saperstein DS, Amato AA, Wolfe GI, et al. Multifocal acquired demyelinating sensory and motor neuropathy: the Lewis‐Sumner syndrome. Muscle Nerve. 1999;22:560‐566.
Doneddu PE, Cocito D, Manganelli F, et al. Atypical CIDP: diagnostic criteria, progression and treatment response. Data from the Italian CIDP database. J Neurol Neurosurg Psychiatry. 2019;90:125‐132.
Beecher G, Howe BM, Shelly S, et al. Plexus MRI helps distinguish the immune‐mediated neuropathies MADSAM and MMN. J Neuroimmunol. 2022;371:577953.
Lewis RA, Sumner AJ, Brown MJ, Asbury AK. Multifocal demyelinating neuropathy with persistent conduction block. Neurology. 1982;32:958‐964.
Léger JM, Beaudet R, Bonnélye G. Treatment of multifocal motor neuropathies with conduction block in France in 2005. Results of a national opinion survey. Rev Neurol (Paris). 2006;162:Spec No 1:3s27–23s45.
Allen DC, Smallman CA, Mills KR. Multifocal acquired demyelinating sensory and motor neuropathy presenting as a peripheral nerve tumor. Muscle Nerve. 2006;34:373‐379.