Lysozyme 1 Inflamed CCR2

RNA cardiovascular diseases inflammation macrophages muramidase

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
26 Jul 2024
Historique:
medline: 26 7 2024
pubmed: 26 7 2024
entrez: 26 7 2024
Statut: aheadofprint

Résumé

Macrophages are key players in obesity-associated cardiovascular diseases, which are marked by inflammatory and immune alterations. However, the pathophysiological mechanisms underlying macrophage's role in obesity-induced cardiac inflammation are incompletely understood. Our study aimed to identify the key macrophage population involved in obesity-induced cardiac dysfunction and investigate the molecular mechanism that contributes to the inflammatory response. Though analyzing in-depth cardiac macrophage clusters identified by single macrophage RNA-sequencing, we find that the Our findings suggest that lysozyme 1 may represent a potential target for the diagnosis of obesity-induced inflammation and the treatment of obesity-induced heart disease.

Sections du résumé

BACKGROUND UNASSIGNED
Macrophages are key players in obesity-associated cardiovascular diseases, which are marked by inflammatory and immune alterations. However, the pathophysiological mechanisms underlying macrophage's role in obesity-induced cardiac inflammation are incompletely understood. Our study aimed to identify the key macrophage population involved in obesity-induced cardiac dysfunction and investigate the molecular mechanism that contributes to the inflammatory response.
METHODS AND RESULTS UNASSIGNED
Though analyzing in-depth cardiac macrophage clusters identified by single macrophage RNA-sequencing, we find that the
CONCLUSIONS UNASSIGNED
Our findings suggest that lysozyme 1 may represent a potential target for the diagnosis of obesity-induced inflammation and the treatment of obesity-induced heart disease.

Identifiants

DOI: 10.1161/CIRCRESAHA.124.324106 PMID: 39056179
pubmed: 39056179
doi: 10.1161/CIRCRESAHA.124.324106
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Lai Zhang (L)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).
Department of Cardiology, The Affiliated Jiangning Hospital of Nanjing Medical University, China (L.Z.).
ORCID: 0000-0002-5245-961X

Huian Han (H)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).
ORCID: 0009-0006-1100-8819

Andi Xu (A)

Department of Pathology, Nanjing Drum Tower Hospital, China (A.X.).
ORCID: 0000-0002-9804-0996

Adwait Sathe (A)

Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas. (A.S., C.X.).
ORCID: 0000-0001-7532-7305

Siying Fu (S)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).

Jiaqi Zhao (J)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).

Wenhan Cai (W)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).
ORCID: 0009-0002-6855-5363

Yaqing Yang (Y)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).
ORCID: 0000-0003-3872-4656

Jinting Liu (J)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).

Hui Bai (H)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).

Jingjing Ben (J)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).
ORCID: 0000-0002-2239-0105

Xudong Zhu (X)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).

Xiaoyu Li (X)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).

Qing Yang (Q)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).

Zidun Wang (Z)

Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, China (Z.W.).
ORCID: 0000-0003-4276-2401

Yayun Gu (Y)

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Jiangsu, China. (Y.G.).

Chao Xing (C)

Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas. (A.S., C.X.).
Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas. (C.X.).
Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas. (C.X.).
ORCID: 0000-0002-1838-0502

Gabriele G Schiattarella (GG)

Max Rubner Center for Cardiovascular Metabolic Renal Research, Deutsches Herzzentrum der Charité, Charité - Universitätsmedizin Berlin, Germany (G.G.S.).
DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany (G.G.S.).
Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (G.G.S.).
ORCID: 0000-0002-7582-7171

Steven Yan Cheng (SY)

Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).
ORCID: 0000-0002-7975-1661

Hanwen Zhang (H)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).
ORCID: 0000-0002-7855-2564

Qi Chen (Q)

Department of Pathophysiology, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., H.Z., Q.C.).
Key Laboratory of Jiangsu Province on Targeted Intervention of Cardiovascular Diseases, Nanjing Medical University, Jiangsu, China. (L.Z., H.H., S.F., J.Z., W.C., Y.Y., J.L., H.B., J.B., X.Z., X.L., Q.Y., S.Y.C., H.Z., Q.C.).
ORCID: 0000-0002-5289-4910

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