A Transcriptomics Analysis of the Regulation of Lens Fiber Cell Differentiation in the Absence of FGFRs and PTEN.

PTEN Phosphohydrolase / metabolism Cell Differentiation / genetics Animals Lens, Crystalline / cytology Mice Signal Transduction Gene Expression Profiling Transcriptome / genetics
EMT FGFRs PDGFRs PTEN RNA-seq inflammation lens lens explants

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
19 Jul 2024
Historique:
received: 24 04 2024
revised: 28 06 2024
accepted: 17 07 2024
medline: 26 7 2024
pubmed: 26 7 2024
entrez: 26 7 2024
Statut: epublish

Résumé

Adding 50% vitreous humor to the media surrounding lens explants induces fiber cell differentiation and a significant immune/inflammatory response. While

Identifiants

DOI: 10.3390/cells13141222 PMID: 39056803
pubmed: 39056803
pii: cells13141222
doi: 10.3390/cells13141222
pii:
doi:

Substances chimiques

PTEN Phosphohydrolase EC 3.1.3.67
Pten protein, mouse EC 3.1.3.67

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NEI NIH HHS
ID : R01 EY012995, R21 EY031092
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Auteurs

Anil Upreti (A)

Cell, Molecular and Structural Biology Program, Miami University, Oxford, OH 45056, USA.
Department of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056, USA.
ORCID: 0000-0001-8502-6506

Stephanie L Padula (SL)

Cell, Molecular and Structural Biology Program, Miami University, Oxford, OH 45056, USA.
Department of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056, USA.

Jacob M Weaver (JM)

Cell, Molecular and Structural Biology Program, Miami University, Oxford, OH 45056, USA.
Department of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056, USA.

Brad D Wagner (BD)

Department of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056, USA.

Allison M Kneller (AM)

Department of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056, USA.

Anthony L Petulla (AL)

Department of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056, USA.

Salil A Lachke (SA)

Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA.
ORCID: 0000-0001-8845-010X

Michael L Robinson (ML)

Cell, Molecular and Structural Biology Program, Miami University, Oxford, OH 45056, USA.
Department of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056, USA.
ORCID: 0000-0003-4779-3426

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Phosphohydrolase PTEN › A Transcriptomics Analysis of the Regulation...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › A Transcriptomics Analysis of the Regulation...
questionsmedicales.fr › Eucaryotes › Animaux › A Transcriptomics Analysis of the Regulation...
questionsmedicales.fr › Organes des sens › Oeil › Pôle antérieur du bulbe oculaire › Cristallin › A Transcriptomics Analysis of the Regulation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A Transcriptomics Analysis of the Regulation...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › A Transcriptomics Analysis of the Regulation...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › A Transcriptomics Analysis of the Regulation...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › A Transcriptomics Analysis of the Regulation...