Global functional connectivity reorganization reflects cognitive processing speed deficits and fatigue in multiple sclerosis.
biomarkers
cognitive processing speed
fMRI
fatigue
multiple sclerosis
Journal
European journal of neurology
ISSN: 1468-1331
Titre abrégé: Eur J Neurol
Pays: England
ID NLM: 9506311
Informations de publication
Date de publication:
26 Jul 2024
26 Jul 2024
Historique:
revised:
28
06
2024
received:
16
04
2024
accepted:
09
07
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
26
7
2024
Statut:
aheadofprint
Résumé
Cognitive impairment (CI) in multiple sclerosis (MS) is associated with bidirectional changes in resting-state centrality measures. However, practicable functional magnetic resonance imaging (fMRI) biomarkers of CI are still lacking. The aim of this study was to assess the graph-theory-based degree rank order disruption index (k Differentiation between PwMS and healthy controls (HCs) using k Analysis in 56 PwMS and 58 HCs (35/27 women, median age 45.1/40.5 years) showed lower k k
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
Cognitive impairment (CI) in multiple sclerosis (MS) is associated with bidirectional changes in resting-state centrality measures. However, practicable functional magnetic resonance imaging (fMRI) biomarkers of CI are still lacking. The aim of this study was to assess the graph-theory-based degree rank order disruption index (k
METHODS
METHODS
Differentiation between PwMS and healthy controls (HCs) using k
RESULTS
RESULTS
Analysis in 56 PwMS and 58 HCs (35/27 women, median age 45.1/40.5 years) showed lower k
CONCLUSIONS
CONCLUSIONS
k
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e16421Subventions
Organisme : Univerzita Karlova v Praze
ID : 260648/SVV/2024
Organisme : Univerzita Karlova v Praze
ID : programme Cooperatio (Neuroscience)
Organisme : European Regional Development Fund
ID : CZ.02.01.01/00/22_008/0004643
Informations de copyright
© 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.
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