High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains.

COVID-19 Imaging mass cytometry Long-COVID Microglia Neuro-long-COVID-19 PACS PCC Post-COVID condition Post-acute COVID syndrome SARS-CoV-2

Journal

Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041

Informations de publication

Date de publication:
25 Jul 2024
Historique:
received: 24 04 2024
accepted: 15 07 2024
revised: 15 07 2024
medline: 27 7 2024
pubmed: 27 7 2024
entrez: 26 7 2024
Statut: epublish

Résumé

The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared to healthy controls, individuals with post-COVID-19 revealed a high percentage of TMEM119

Identifiants

DOI: 10.1007/s00401-024-02770-6 PMID: 39060438
pubmed: 39060438
doi: 10.1007/s00401-024-02770-6
pii: 10.1007/s00401-024-02770-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11

Informations de copyright

© 2024. The Author(s).

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Auteurs

Marius Schwabenland (M)

Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.
ORCID: 0000-0003-2205-5427

Dilara Hasavci (D)

Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.

Sibylle Frase (S)

Department of Neurology and Neuroscience, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Katharina Wolf (K)

Department of Neurology and Neuroscience, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany.

Nikolaus Deigendesch (N)

Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
ORCID: 0000-0002-6036-3327

Joerg M Buescher (JM)

Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany.

Kirsten D Mertz (KD)

Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland.
University of Basel, Basel, Switzerland.

Benjamin Ondruschka (B)

Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Hermann Altmeppen (H)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Jakob Matschke (J)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Markus Glatzel (M)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Stephan Frank (S)

Division of Neuropathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.

Robert Thimme (R)

Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.

Juergen Beck (J)

Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany.

Jonas A Hosp (JA)

Department of Neurology and Neuroscience, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Thomas Blank (T)

Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.

Bertram Bengsch (B)

Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.
Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.

Marco Prinz (M)

Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany. marco.prinz@uniklinik-freiburg.de.
Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. marco.prinz@uniklinik-freiburg.de.
ORCID: 0000-0002-0349-1955

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