Prevalence of alcohol-impaired driving: a systematic review with a gender-driven approach and meta-analysis of gender differences.

Alcohol DUI Forensic Toxicology Gender Prevalence Traffic medicine

Journal

International journal of legal medicine
ISSN: 1437-1596
Titre abrégé: Int J Legal Med
Pays: Germany
ID NLM: 9101456

Informations de publication

Date de publication:
26 Jul 2024
Historique:
received: 19 04 2024
accepted: 09 07 2024
medline: 27 7 2024
pubmed: 27 7 2024
entrez: 26 7 2024
Statut: aheadofprint

Résumé

A growing number of studies investigated the factors that contribute to driving under the influence (DUI) of alcohol in relation to gender. However, a gendered approach of the scientific evidence is missing in the literature. To fill this gap, a gender-driven systematic review on real case studies of the last two decades was performed. In addition to the gender of the drivers involved, major independent variables such as the period of recruitment, the type of drivers recruited, and the geographical area where the study was conducted, were examined. Afterwards, a meta-analysis was performed comparing alcohol-positive rates (APR) between male and female drivers in three subgroups of drivers: those involved in road traffic accidents, those randomly tested on the road, and volunteers. Three databases were searched for eligible studies in October 2023. Real-case studies reporting APR in man and women convicted for DUI of alcohol worldwide were included. Univariate analysis by ANOVA with post-hoc tests identified the independent variables with a significant impact on the dependent variable APR, according to a relationship subsequently investigated by standard multiple linear regression. The meta-analysis of random effects estimates was performed to investigate the change in overall effect size (measured by Cohen's d standardized mean difference test) and 95% confidence interval (CI). Among papers addressing driver gender, univariate analysis of independent variables revealed a higher Alcohol Positive Rate (APR) in men, particularly in drivers involved in crashes, with a noticeable decrease over time. Analyzing the gender of drivers involved in crashes, the meta-analysis showed that men had a significantly higher APR (30.7%; 95%CI 26.8-35.0) compared to women (13.2%; 95%CI 10.7-16.1). However, in drivers randomly tested, there was no significant difference in APR between genders (2.1% for men and 1.4% for women), while in volunteers, there was a statistically significant difference in APR with 3.4% (95%CI 1.5-7.6) for men and 1.1% (95%CI 0.5-2.7) for women. Despite a progressive decrease in the epidemiological prevalence of alcohol-related DUI over time, this phenomenon remains at worryingly high levels among drivers involved in road traffic accidents in both genders, with a higher prevalence in men. It's important for policymakers, professionals, and scientists to consider gender when planning research, analysis, interventions, and policies related to psychoactive substances, such as alcohol or other licit drugs. Forensic sciences can play a vital role in this regard, enabling a thorough analysis of gender gaps in different populations.

Sections du résumé

BACKGROUND BACKGROUND
A growing number of studies investigated the factors that contribute to driving under the influence (DUI) of alcohol in relation to gender. However, a gendered approach of the scientific evidence is missing in the literature. To fill this gap, a gender-driven systematic review on real case studies of the last two decades was performed. In addition to the gender of the drivers involved, major independent variables such as the period of recruitment, the type of drivers recruited, and the geographical area where the study was conducted, were examined. Afterwards, a meta-analysis was performed comparing alcohol-positive rates (APR) between male and female drivers in three subgroups of drivers: those involved in road traffic accidents, those randomly tested on the road, and volunteers.
METHODS METHODS
Three databases were searched for eligible studies in October 2023. Real-case studies reporting APR in man and women convicted for DUI of alcohol worldwide were included. Univariate analysis by ANOVA with post-hoc tests identified the independent variables with a significant impact on the dependent variable APR, according to a relationship subsequently investigated by standard multiple linear regression. The meta-analysis of random effects estimates was performed to investigate the change in overall effect size (measured by Cohen's d standardized mean difference test) and 95% confidence interval (CI).
RESULTS RESULTS
Among papers addressing driver gender, univariate analysis of independent variables revealed a higher Alcohol Positive Rate (APR) in men, particularly in drivers involved in crashes, with a noticeable decrease over time. Analyzing the gender of drivers involved in crashes, the meta-analysis showed that men had a significantly higher APR (30.7%; 95%CI 26.8-35.0) compared to women (13.2%; 95%CI 10.7-16.1). However, in drivers randomly tested, there was no significant difference in APR between genders (2.1% for men and 1.4% for women), while in volunteers, there was a statistically significant difference in APR with 3.4% (95%CI 1.5-7.6) for men and 1.1% (95%CI 0.5-2.7) for women.
CONCLUSION CONCLUSIONS
Despite a progressive decrease in the epidemiological prevalence of alcohol-related DUI over time, this phenomenon remains at worryingly high levels among drivers involved in road traffic accidents in both genders, with a higher prevalence in men. It's important for policymakers, professionals, and scientists to consider gender when planning research, analysis, interventions, and policies related to psychoactive substances, such as alcohol or other licit drugs. Forensic sciences can play a vital role in this regard, enabling a thorough analysis of gender gaps in different populations.

Identifiants

pubmed: 39060442
doi: 10.1007/s00414-024-03291-3
pii: 10.1007/s00414-024-03291-3
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Références

Mauvais-Jarvis F, Bairey Merz N, Barnes PJ, Brinton RD, Carrero J-J, DeMeo DL, De Vries GJ, Epperson CN, Govindan R, Klein SL, Lonardo A, Maki PM, McCullough LD, Regitz-Zagrosek V, Regensteiner JG, Rubin JB, Sandberg K, Suzuki A (2020) Sex and gender: modifiers of health, disease, and medicine. Lancet 396:565–582. https://doi.org/10.1016/S0140-6736(20)31561-0
doi: 10.1016/S0140-6736(20)31561-0 pubmed: 32828189 pmcid: 7440877
Steingrímsson S, Carlsen HK, Sigfússon S, Magnússon A (2012) The changing gender gap in substance use disorder: a total population-based study of psychiatric in-patients. Addiction 107:1957–1962. https://doi.org/10.1111/j.1360-0443.2012.03954.x
doi: 10.1111/j.1360-0443.2012.03954.x pubmed: 22632169
Barone R, Pelletti G, Garagnani M, Giusti A, Marzi M, Rossi F, Roffi R, Fais P, Pelotti S (2019) Alcohol and illicit drugs in drivers involved in road traffic crashes in Italy. An 8-year retrospective study. Forensic Sci Int 305:110004. https://doi.org/10.1016/j.forsciint.2019.110004
doi: 10.1016/j.forsciint.2019.110004 pubmed: 31707239
Marinelli S, Basile G, Manfredini R, Zaami S (2023) Sex- and gender-specific drug abuse dynamics: the need for tailored therapeutic approaches. J Pers Med 13:965. https://doi.org/10.3390/jpm13060965
doi: 10.3390/jpm13060965 pubmed: 37373954 pmcid: 10304701
Buccelli C, Della Casa E, Paternoster M, Niola M, Pieri M (2016) Gender differences in drug abuse in the forensic toxicological approach. Forensic Sci Int 265:89–95. https://doi.org/10.1016/j.forsciint.2016.01.014
doi: 10.1016/j.forsciint.2016.01.014 pubmed: 26836148
Gjerde H, Ramaekers JG, Mørland JG (2020) Methodologies for Establishing the Relationship between Alcohol/Drug Use and Driving Impairment: Differences between Epidemiological, Experimental, and Real-Case Studies, in: A. Wayne Jones, J. Morland, R.H. Liu (Eds.), Alcohol, Drugs, and Impaired Driving, Taylor and Francis, : pp. 581–610. https://doi.org/10.4324/9781003030799
Pelletti G, Verstraete AG, Reyns T, Barone R, Rossi F, Garagnani M, Pelotti S (2019) Prevalence of therapeutic drugs in blood of drivers involved in traffic crashes in the area of Bologna, Italy. Forensic Sci Int 302:109914. https://doi.org/10.1016/j.forsciint.2019.109914
doi: 10.1016/j.forsciint.2019.109914 pubmed: 31419592
Robertson AA, Liew H, Gardner S (2011) An evaluation of the narrowing gender gap in DUI arrests. Accid Anal Prev 43:1414–1420. https://doi.org/10.1016/j.aap.2011.02.017
doi: 10.1016/j.aap.2011.02.017 pubmed: 21545874
Schwartz J, Beltz L (2018) Trends in female and male drunken driving prevalence over thirty years: triangulating diverse sources of evidence (1985–2015). Addict Behav 84:7–12. https://doi.org/10.1016/j.addbeh.2018.03.024
doi: 10.1016/j.addbeh.2018.03.024 pubmed: 29587173
McMurran M, Riemsma R, Manning N, Misso K, Kleijnen J (2011) Interventions for alcohol-related offending by women: a systematic review. Clin Psychol Rev 31:909–922. https://doi.org/10.1016/j.cpr.2011.04.005
doi: 10.1016/j.cpr.2011.04.005 pubmed: 21601553
Pelletti G, Boscolo-Berto R, Barone R, Giorgetti A, Fiorentini C, Pascali JP, Fais P, Pelotti S (2022) Gender differences in driving under the influence of psychoactive drugs: evidence mapping of real case studies and meta-analysis. Forensic Sci Int 341:111479. https://doi.org/10.1016/j.forsciint.2022.111479
doi: 10.1016/j.forsciint.2022.111479 pubmed: 36279739
Moher D, Liberati A, Tetzlaff J, Altman DG, Group PRISMA (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097. https://doi.org/10.1371/journal.pmed.1000097
doi: 10.1371/journal.pmed.1000097 pubmed: 19621072 pmcid: 2707599
McInnes MDF, Moher D, Thombs BD, McGrath TA, Bossuyt PM, and the, PRISMA-DTA Group T, Clifford JF, Cohen JJ, Deeks C, Gatsonis L, Hooft HA, Hunt CJ, Hyde DA, Korevaar MMG, Leeflang P, Macaskill JB, Reitsma R, Rodin AWS, Rutjes J-P, Salameh A, Stevens Y, Takwoingi M, Tonelli L, Weeks P, Whiting BH, Willis (2018) Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies: The PRISMA-DTA Statement, JAMA 319 388–396. https://doi.org/10.1001/jama.2017.19163
Boscolo-Berto R, Viel G, Cecchi R, Terranova C, Vogliardi S, Bajanowski T, Ferrara SD (2012) Journals publishing bio-medicolegal research in Europe. Int J Legal Med 126:129–137. https://doi.org/10.1007/s00414-011-0620-3
doi: 10.1007/s00414-011-0620-3 pubmed: 21938503
Viel G, Boscolo-Berto R, Cecchi R, Bajanowski T, Vieira ND, Ferrara SD (2011) Bio-medicolegal scientific research in Europe. A country-based analysis. Int J Legal Med 125:717–725. https://doi.org/10.1007/s00414-011-0576-3
doi: 10.1007/s00414-011-0576-3 pubmed: 21594612
Daglioglu N, Efeoglu Ozseker P, Dengiz H, Kekec Z (2022) Determination of phosphatidyl ethanol (PEth) 16:0/18:1 in dried blood samples of drivers involved in traffic accidents: a pilot study. Leg Med (Tokyo) 58:102091. https://doi.org/10.1016/j.legalmed.2022.102091
doi: 10.1016/j.legalmed.2022.102091 pubmed: 35623236
Oyono Y, Gjerde H, Acha Asongalem E, Kouomogne Nteungue BA, Bamuh E, Deuwa Ngako A, Kelley-Baker T, Ramaekers JG, Lontsi L, Sonwa G, Enow-Orock E (2021) Achidi Akum, Roadside surveys of drinking and driving in Cameroon. Traffic Inj Prev 22:349–354. https://doi.org/10.1080/15389588.2021.1922682
doi: 10.1080/15389588.2021.1922682 pubmed: 34014768
Huang C-Y, Chou S-E, Su W-T, Liu H-T, Hsieh T-M, Hsu S-Y, Hsieh H-Y, Hsieh C-H (2020) Effect of lowering the blood alcohol concentration limit to 0.03 among hospitalized trauma patients in Southern Taiwan: a cross-sectional analysis. Risk Manag Healthc Policy 13:571–581. https://doi.org/10.2147/RMHP.S250734
doi: 10.2147/RMHP.S250734 pubmed: 32607025 pmcid: 7305841
Jamt REG, Gjerde H, Furuhaugen H, Romeo G, Vindenes V, Ramaekers JG, Bogstrand ST (2020) Associations between psychoactive substance use and sensation seeking behavior among drivers in Norway. BMC Public Health 20:23. https://doi.org/10.1186/s12889-019-8087-0
doi: 10.1186/s12889-019-8087-0 pubmed: 31914964 pmcid: 6950984
Papalimperi AH, Athanaselis SA, Mina AD, Papoutsis II, Spiliopoulou CA, Papadodima SA (2019) Incidence of fatalities of road traffic accidents associated with alcohol consumption and the use of psychoactive drugs: a 7-year survey (2011–2017). Exp Ther Med 18:2299–2306. https://doi.org/10.3892/etm.2019.7787
doi: 10.3892/etm.2019.7787 pubmed: 31410180 pmcid: 6676144
Valen A, Bogstrand ST, Vindenes V, Frost J, Larsson M, Holtan A, Gjerde H (2019) Fatally injured drivers in Norway 2005-2015-Trends in substance use and crash characteristics. Traffic Inj Prev 20:460–466. https://doi.org/10.1080/15389588.2019.1616700
doi: 10.1080/15389588.2019.1616700 pubmed: 31169405
Pešić D, Antić B, Smailović E, Marković N (2019) Driving under the influence of alcohol and the effects of alcohol prohibition-case study in Serbia. Traffic Inj Prev 20:467–471. https://doi.org/10.1080/15389588.2019.1612058
doi: 10.1080/15389588.2019.1612058 pubmed: 31157552
Romano E, Kelley-Baker T, Hoff S, Eichelberger A, Ramírez A (2019) Use of Alcohol and Cannabis among adults driving children in Washington State. J Stud Alcohol Drugs 80:196–200. https://doi.org/10.15288/jsad.2019.80.196
doi: 10.15288/jsad.2019.80.196 pubmed: 31014464 pmcid: 6489546
Seesen M, Siviroj P, Sapbamrer R, Morarit S (2019) High blood alcohol concentration associated with traumatic brain injury among traffic injury patients during New Year festivals in Thailand. Traffic Inj Prev 20:115–121. https://doi.org/10.1080/15389588.2018.1547379
doi: 10.1080/15389588.2018.1547379 pubmed: 30892946
Jørgenrud B, Bogstrand ST, Furuhaugen H, Jamt REG, Vindenes V, Gjerde H (2018) Association between speeding and use of alcohol and medicinal and illegal drugs and involvement in road traffic crashes among motor vehicle drivers. Traffic Inj Prev 19:779–785. https://doi.org/10.1080/15389588.2018.1518577
doi: 10.1080/15389588.2018.1518577 pubmed: 30681887
Kalsi J, Selander T, Tervo T (2018) Alcohol policy and fatal alcohol-related crashes in Finland 2000–2016. Traffic Inj Prev 19:476–479. https://doi.org/10.1080/15389588.2018.1443325
doi: 10.1080/15389588.2018.1443325 pubmed: 29485912
Ferrari D, Manca M, Banfi G, Locatelli M (2018) Alcohol and illicit drugs in drivers involved in road traffic crashes in the Milan area. A comparison with normal traffic reveals the possible inadequacy of current cut-off limits. Forensic Sci Int 282:127–132. https://doi.org/10.1016/j.forsciint.2017.11.005
doi: 10.1016/j.forsciint.2017.11.005 pubmed: 29197242
Santoyo-Castillo D, Pérez-Núñez R, Borges G, Híjar M (2018) Estimating the drink driving attributable fraction of road traffic deaths in Mexico. Addiction 113:828–835. https://doi.org/10.1111/add.14153
doi: 10.1111/add.14153 pubmed: 29274185
Martin J-L, Gadegbeku B, Wu D, Viallon V, Laumon B (2017) Cannabis, alcohol and fatal road accidents. PLoS ONE 12:e0187320. https://doi.org/10.1371/journal.pone.0187320
doi: 10.1371/journal.pone.0187320 pubmed: 29117206 pmcid: 5678710
Domingo-Salvany A, Herrero MJ, Fernandez B, Perez J, Del Real P, González-Luque JC, de la Torre R (2017) Prevalence of psychoactive substances, alcohol and illicit drugs, in Spanish drivers: a roadside study in 2015. Forensic Sci Int 278:253–259. https://doi.org/10.1016/j.forsciint.2017.07.005
doi: 10.1016/j.forsciint.2017.07.005 pubmed: 28778032
Kirsch B, Birngruber CG, Dettmeyer R (2017) Senior driving under the influence: a five-year retrospective study of alcoholized road-users aged 70 and over. Forensic Sci Int 277:10–15. https://doi.org/10.1016/j.forsciint.2017.05.002
doi: 10.1016/j.forsciint.2017.05.002 pubmed: 28544918
Cittadini F, De Giovanni N, Caradonna L, Vetrugno G, Oliva A, Fucci N, Zuppi C, Pascali VL, Covino M (2017) Prevalence of alcohol and other drugs in injured drivers and their association with clinical outcomes. Eur Rev Med Pharmacol Sci 21:2008–2014
pubmed: 28537688
Jamt REG, Gjerde H, Normann PT, Bogstrand ST (2017) Roadside survey on alcohol and drug use among drivers in the Arctic county of Finnmark (Norway). Traffic Inj Prev 18:681–687. https://doi.org/10.1080/15389588.2017.1283027
doi: 10.1080/15389588.2017.1283027 pubmed: 28112544
Sobngwi-Tambekou JL, Brown TG, Bhatti JA (2016) Driving under the influence of alcohol in professional drivers in Cameroon, Traffic Inj Prev 17 suppl 1. 73–78. https://doi.org/10.1080/15389588.2016.1199867
Petković S, Palić K, Samojlik I (2016) Blood alcohol concentration in fatally injured drivers and the efficacy of alcohol policies of the new law on road traffic safety: a retrospective 10-year study in autonomous province of Vojvodina, Republic of Serbia. Traffic Inj Prev 17:553–557. https://doi.org/10.1080/15389588.2015.1125479
doi: 10.1080/15389588.2015.1125479 pubmed: 26761423
Jomar RT, de Ramos D, Abreu ÂMM (2016) Breathalyzer test: results and refusals to take the test of drivers intercepted under the DUI spot-check campaign in Rio De Janeiro. Cien Saude Colet 21:3787–3792. https://doi.org/10.1590/1413-812320152112.20572015
doi: 10.1590/1413-812320152112.20572015 pubmed: 27925119
Bonilla-Escobar FJ, Herrera-López ML, Ortega-Lenis D, Medina-Murillo JJ, Fandiño-Losada A, Jaramillo-Molina C, Naranjo-Lujan S, Izquierdo EP, Vanlaar W (2016) Gutiérrez-Martínez, driving under the influence of alcohol in Cali, Colombia: prevalence and consumption patterns, 2013. Int J Inj Contr Saf Promot 23:179–188. https://doi.org/10.1080/17457300.2014.966120
doi: 10.1080/17457300.2014.966120 pubmed: 25563805
Legrand S-A, Silverans P, de Paepe P, Buylaert W, Verstraete AG (2013) Presence of psychoactive substances in injured Belgian drivers. Traffic Inj Prev 14:461–468. https://doi.org/10.1080/15389588.2012.716881
doi: 10.1080/15389588.2012.716881 pubmed: 23682981
Yuan A, Li Y, Zhang J (2013) The result of a baseline survey on drink driving in Nanning and Liuzhou of Guangxi Province, China. Traffic Inj Prev 14:230–236. https://doi.org/10.1080/15389588.2012.701785
doi: 10.1080/15389588.2012.701785 pubmed: 23441940
Kelley-Baker T, Lacey JH, Voas RB, Romano E, Yao J, Berning A (2013) Drinking and driving in the United States: comparing results from the 2007 and 1996 National Roadside surveys. Traffic Inj Prev 14. https://doi.org/10.1080/15389588.2012.697229
Institóris L, Tóth AR, Molnár A, Arok Z, Kereszty E, Varga T (2013) The frequency of alcohol, illicit and licit drug consumption in the general driving population in South-East Hungary. Forensic Sci Int 224:37–43. https://doi.org/10.1016/j.forsciint.2012.10.022
doi: 10.1016/j.forsciint.2012.10.022 pubmed: 23149316
Palmentier J-PFP, Warren R, Gorczynski LY (2009) Alcohol and drugs in suspected impaired drivers in Ontario from 2001 to 2005. J Forensic Leg Med 16:444–448. https://doi.org/10.1016/j.jflm.2009.05.002
doi: 10.1016/j.jflm.2009.05.002 pubmed: 19782313
Tsai Y-C, Wu S-C, Huang J-F, Kuo SCH, Rau C-S, Chien P-C, Hsieh H-Y, Hsieh C-H (2019) The effect of lowering the legal blood alcohol concentration limit on driving under the influence (DUI) in southern Taiwan: a cross-sectional retrospective analysis. BMJ Open 9:e026481. https://doi.org/10.1136/bmjopen-2018-026481
doi: 10.1136/bmjopen-2018-026481 pubmed: 31005931 pmcid: 6528014
Zador PL, Krawchuk SA, Voas RB (2000) Alcohol-related relative risk of driver fatalities and driver involvement in fatal crashes in relation to driver age and gender: an update using 1996 data. J Stud Alcohol 61:387–395. https://doi.org/10.15288/jsa.2000.61.387
doi: 10.15288/jsa.2000.61.387 pubmed: 10807209
Hamnett HJ, Ilett M, Izzati F, Smith SS, Watson KH (2017) Toxicological findings in driver and motorcyclist fatalities in Scotland 2012–2015. Forensic Sci Int 274:22–26. https://doi.org/10.1016/j.forsciint.2016.12.034
doi: 10.1016/j.forsciint.2016.12.034 pubmed: 28109625
du Plessis M, Hlaise KK, Blumenthal R (2016) Ethanol-related death in Ga-Rankuwa road-users, South Africa: a five-year analysis. J Forensic Leg Med 44:5–9. https://doi.org/10.1016/j.jflm.2016.08.006
doi: 10.1016/j.jflm.2016.08.006 pubmed: 27589378
Brubacher JR, Chan H, Martz W, Schreiber W, Asbridge M, Eppler J, Lund A, Macdonald S, Drummer O, Purssell R, Andolfatto G, Mann R, Brant R (2016) Prevalence of alcohol and drug use in injured british Columbia drivers. BMJ Open 6:e009278. https://doi.org/10.1136/bmjopen-2015-009278
doi: 10.1136/bmjopen-2015-009278 pubmed: 26966054 pmcid: 4800149
Liu C, Huang Y, Pressley JC (2016) Restraint use and risky driving behaviors across drug types and drug and alcohol combinations for drivers involved in a fatal motor vehicle collision on U.S. roadways. Inj Epidemiol 3:9. https://doi.org/10.1186/s40621-016-0074-7
doi: 10.1186/s40621-016-0074-7 pubmed: 27747546 pmcid: 4819806
Legrand S-A, Gjerde H, Isalberti C, Van der Linden T, Lillsunde P, Dias MJ, Gustafsson S, Ceder G, Verstraete AG (2014) Prevalence of alcohol, illicit drugs and psychoactive medicines in killed drivers in four European countries. Int J Inj Contr Saf Promot 21:17–28. https://doi.org/10.1080/17457300.2012.748809
doi: 10.1080/17457300.2012.748809 pubmed: 23297822
Brady JE, Li G (2014) Trends in alcohol and other drugs detected in fatally injured drivers in the United States, 1999–2010. Am J Epidemiol 179:692–699. https://doi.org/10.1093/aje/kwt327
doi: 10.1093/aje/kwt327 pubmed: 24477748 pmcid: 3939850
Brady JE, Li G (2013) Prevalence of alcohol and other drugs in fatally injured drivers. Addiction 108:104–114. https://doi.org/10.1111/j.1360-0443.2012.03993.x
doi: 10.1111/j.1360-0443.2012.03993.x pubmed: 22725100
Rao Y, Zhao Z, Zhang Y, Ye Y, Zhang R, Liang C, Wang R, Sun Y, Jiang Y (2013) Prevalence of blood alcohol in fatal traffic crashes in Shanghai. Forensic Sci Int 224:117–122. https://doi.org/10.1016/j.forsciint.2012.11.011
doi: 10.1016/j.forsciint.2012.11.011 pubmed: 23265442
Kuypers KPC, Legrand S-A, Ramaekers JG, Verstraete AG (2012) A case-control study estimating accident risk for alcohol, medicines and illegal drugs. PLoS ONE 7:e43496. https://doi.org/10.1371/journal.pone.0043496
doi: 10.1371/journal.pone.0043496 pubmed: 22952694 pmcid: 3429508
Stübig T, Petri M, Zeckey C, Brand S, Müller C, Otte D, Krettek C, Haasper C (2012) Alcohol intoxication in road traffic accidents leads to higher impact speed difference, higher ISS and MAIS, and higher preclinical mortality. Alcohol 46:681–686. https://doi.org/10.1016/j.alcohol.2012.07.002
doi: 10.1016/j.alcohol.2012.07.002 pubmed: 22819121
Costa N, Silva R, Mendonça MC, Real FC, Vieira DN, Teixeira HM (2012) Prevalence of ethanol and illicit drugs in road traffic accidents in the centre of Portugal: an eighteen-year update. Forensic Sci Int 216:37–43. https://doi.org/10.1016/j.forsciint.2011.08.013
doi: 10.1016/j.forsciint.2011.08.013 pubmed: 21908111
Gómez-Talegón T, Fierro I, González-Luque JC, Colás M, López-Rivadulla M, Javier F, Álvarez (2012) Prevalence of psychoactive substances, alcohol, illicit drugs, and medicines, in Spanish drivers: a roadside study. Forensic Sci Int 223:106–113. https://doi.org/10.1016/j.forsciint.2012.08.012
doi: 10.1016/j.forsciint.2012.08.012 pubmed: 22947432
Poulsen H, Moar R, Troncoso C (2012) The incidence of alcohol and other drugs in drivers killed in New Zealand road crashes 2004–2009. Forensic Sci Int 223:364–370. https://doi.org/10.1016/j.forsciint.2012.10.026
doi: 10.1016/j.forsciint.2012.10.026 pubmed: 23131305
Legrand S-A, Isalberti C, der Linden TV, Bernhoft IM, Hels T, Simonsen KW, Favretto D, Ferrara SD, Caplinskiene M, Minkuviene Z, Pauliukevicius A, Houwing S, Mathijssen R, Lillsunde P, Langel K, Blencowe T, Verstraete AG (2013) Alcohol and drugs in seriously injured drivers in six European countries. Drug Test Anal 5:156–165. https://doi.org/10.1002/dta.1393
doi: 10.1002/dta.1393 pubmed: 22887894
İdi̇z N, Karakuş A, Dalgiç M, Meseri̇ R, Akgür SA (2011) The Alcohol Levels in Fatal & Nonfatal Traffic Accidents in İzmir. Turkiye Klinikleri J Foren Sci Leg Med 8:6–11
Gjerde H, Normann PT, Pettersen BS, Assum T, Aldrin M, Johansen U, Kristoffersen L, Øiestad EL, Christophersen AS, Mørland J (2008) Prevalence of alcohol and drugs among Norwegian motor vehicle drivers: a roadside survey. Accid Anal Prev 40:1765–1772. https://doi.org/10.1016/j.aap.2008.06.015
doi: 10.1016/j.aap.2008.06.015 pubmed: 18760106
Plurad D, Demetriades D, Gruzinski G, Preston C, Chan L, Gaspard D, Margulies D, Cryer G (2010) Motor vehicle crashes: the association of alcohol consumption with the type and severity of injuries and outcomes. J Emerg Med 38:12–17. https://doi.org/10.1016/j.jemermed.2007.09.048
doi: 10.1016/j.jemermed.2007.09.048 pubmed: 18547772
Jones AW, Kugelberg FC, Holmgren A, Ahlner J (2009) Five-year update on the occurrence of alcohol and other drugs in blood samples from drivers killed in road-traffic crashes in Sweden. Forensic Sci Int 186:56–62. https://doi.org/10.1016/j.forsciint.2009.01.014
doi: 10.1016/j.forsciint.2009.01.014 pubmed: 19232848
Santamariña-Rubio E, Pérez K, Ricart I, Rodríguez-Sanz M, Rodríguez-Martos A, Brugal MT, Borrell C, Ariza C, Díez E, Beneyto VM, Nebot M, Ramos P, Suelves JM (2009) Substance use among road traffic casualties admitted to emergency departments. Inj Prev 15:87–94. https://doi.org/10.1136/ip.2008.019679
doi: 10.1136/ip.2008.019679 pubmed: 19346420
Gjerde H, Christophersen AS, Normann PT, Mørland J (2011) Toxicological investigations of drivers killed in road traffic accidents in Norway during 2006–2008. Forensic Sci Int 212:102–109. https://doi.org/10.1016/j.forsciint.2011.05.021
doi: 10.1016/j.forsciint.2011.05.021 pubmed: 21665393
Peck RC, Gebers MA, Voas RB, Romano E (2008) The relationship between blood alcohol concentration (BAC), age, and crash risk. J Saf Res 39:311–319. https://doi.org/10.1016/j.jsr.2008.02.030
doi: 10.1016/j.jsr.2008.02.030
Keall MD, Frith WJ, Patterson TL (2004) The influence of alcohol, age and number of passengers on the night-time risk of driver fatal injury in New Zealand. Accid Anal Prev 36:49–61. https://doi.org/10.1016/s0001-4575(02)00114-8
doi: 10.1016/s0001-4575(02)00114-8 pubmed: 14572827
Shih H-C, Hu S-C, Yang C-C, Ko T-J, Wu J-K, Lee C-H (2003) Alcohol intoxication increases morbidity in drivers involved in motor vehicle accidents. Am J Emerg Med 21:91–94. https://doi.org/10.1053/ajem.2003.50025
doi: 10.1053/ajem.2003.50025 pubmed: 12671806
Fabbri A, Marchesini G, Morselli-Labate AM, Rossi F, Cicognani A, Dente M, Iervese T, Ruggeri S, Mengozzi U, Vandelli A (2002) Positive blood alcohol concentration and road accidents. A prospective study in an Italian emergency department. Emerg Med J 19:210–214. https://doi.org/10.1136/emj.19.3.210
doi: 10.1136/emj.19.3.210 pubmed: 11971829 pmcid: 1725851
Whiting PF, Rutjes AWS, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, Leeflang MMG, Sterne JAC, Bossuyt PMM (2011) QUADAS-2 Group, QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 155:529–536. https://doi.org/10.7326/0003-4819-155-8-201110180-00009
doi: 10.7326/0003-4819-155-8-201110180-00009 pubmed: 22007046
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71
doi: 10.1136/bmj.n71 pubmed: 33782057 pmcid: 8005924
Boscolo-Berto R, Favretto D, Cecchetto G, Vincenti M, Kronstrand R, Ferrara SD, Viel G (2014) Sensitivity and specificity of EtG in hair as a marker of chronic excessive drinking: pooled analysis of raw data and meta-analysis of diagnostic accuracy studies. Ther Drug Monit 36:560–575. https://doi.org/10.1097/FTD.0000000000000063
doi: 10.1097/FTD.0000000000000063 pubmed: 24577122
Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101
doi: 10.2307/2533446 pubmed: 7786990
Berghaus G (2007) Meta-analyses in research in forensic medicine: Alcohol, drugs, diseases and traffic safety. Forensic Sci Int 165:108–110. https://doi.org/10.1016/j.forsciint.2006.05.011
doi: 10.1016/j.forsciint.2006.05.011 pubmed: 16781102
Giorgetti A, Pascali JP, Pelletti G, Garagnani M, Roffi R, Grech M, Fais P (2024) Optimizing screening cutoffs for drugs of abuse in hair using immunoassay for forensic applications. Adv Clin Exp Med. https://doi.org/10.17219/acem/183124
doi: 10.17219/acem/183124 pubmed: 38411387
Boscolo-Berto R (2024) Challenges and future trends of forensic toxicology to keep a cut above the rest. Adv Clin Exp Med. https://doi.org/10.17219/acem/185730
doi: 10.17219/acem/185730 pubmed: 38515257
Chin JM, Growns B, Sebastian J, Page MJ, Nakagawa S (2022) The transparency and reproducibility of systematic reviews in forensic science. Forensic Sci Int 340:111472. https://doi.org/10.1016/j.forsciint.2022.111472
doi: 10.1016/j.forsciint.2022.111472 pubmed: 36179444
Driving Under the Influence of Drugs (2024) Alcohol and Medicines in Europe — findings from the DRUID project | ( www.emcdda.europa.eu , (n.d.). https://www.emcdda.europa.eu/publications/thematic-papers/druid_en
Cheng W-C, Dao K-L (2017) The occurrence of alcohol/drugs by toxicological examination of selected drivers in Hong Kong. Forensic Sci Int 275:242–253. https://doi.org/10.1016/j.forsciint.2017.03.022
doi: 10.1016/j.forsciint.2017.03.022 pubmed: 28412576
Papa P, Rocchi L, Rolandi LM, Di Tuccio M, Biffi M, Valli A (2017) Illicit drugs in Emergency Department patients injured in road traffic accidents. Annali Dell’Istituto Superiore Di Sanita 53:35–39. https://doi.org/10.4415/ANN_17_01_08
doi: 10.4415/ANN_17_01_08 pubmed: 28361803
Reilly K, Woodruff SI, Hohman M, Barker M (2019) Gender differences in driving under the influence (DUI) program client characteristics: implications for treatment delivery. Women Health 59:132–144. https://doi.org/10.1080/03630242.2018.1434589
doi: 10.1080/03630242.2018.1434589 pubmed: 29400615
Fell JC (2019) Approaches for reducing alcohol-impaired driving: evidence-based legislation, law enforcement strategies, sanctions, and alcohol-control policies. Forensic Sci Rev 31:161–184
pubmed: 31270060
Terranova C, Cestonaro C, Cinquetti A, Trevissoi F, Favretto D, Viel G, AnnaAprile (2024) Sex differences and driving impairment related to psychoactive substances. Traffic Injury Prev DOI. https://doi.org/10.1080/15389588.2024.2325607
doi: 10.1080/15389588.2024.2325607

Auteurs

Guido Pelletti (G)

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, Bologna, 40126, Italy.

Rafael Boscolo-Berto (R)

Institute of Human Anatomy, Department of Neurosciences, University of Padova, Via A. Gabelli 65, Padua, 35127, Italy.

Laura Anniballi (L)

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, Bologna, 40126, Italy.

Arianna Giorgetti (A)

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, Bologna, 40126, Italy.

Filippo Pirani (F)

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, Bologna, 40126, Italy.

Mara Cavallaro (M)

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, Bologna, 40126, Italy.

Luca Giorgini (L)

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, Bologna, 40126, Italy.

Paolo Fais (P)

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, Bologna, 40126, Italy. paolo.fais@unibo.it.

Jennifer Paola Pascali (JP)

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, Bologna, 40126, Italy.

Susi Pelotti (S)

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, Bologna, 40126, Italy.

Classifications MeSH