Architecture and anatomy of executive processes: evidence from verbal fluency and Trail Making Test in 2009 stroke patients.
Dementia
Executive functions
Infarct
Lesion-symptom mapping
Mild cognitive impairment
Stroke
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
26 Jul 2024
26 Jul 2024
Historique:
received:
21
04
2024
accepted:
23
06
2024
revised:
21
06
2024
medline:
27
7
2024
pubmed:
27
7
2024
entrez:
26
7
2024
Statut:
aheadofprint
Résumé
The few voxel-wise lesion-symptom mapping (VLSM) studies aimed at identifying the anatomy of executive function are limited by the absence of a model and by small populations. Using Trail Making Test (TMT) and verbal fluency and a model of their architectures, our objective was to identify the key structures underlying two major executive processes, set-shifting and strategic word search. We applied a validated VLSM analysis to harmonized cognitive and imaging data from 2009 ischemic stroke patients as a part of the Meta VCI Map consortium. All contrast analyses used an adjusted threshold with 2000 Freedman-Lane permutations (p ≤ 0.05). The TMT parts A and B were associated with structures involved in visual-spatial processing, the motor system, the frontal lobes, and their subcortical connections. Set-shifting depended on the left dorsomedial frontal region. Both semantic and phonemic fluency tests depended on verbal output abilities and processing speed with similar slopes in different languages. The strategic search process depended on Broca's area, F2 and related tracts, temporal and deep regions. Lastly, the lesion map of set-shifting did not overlap with those of strategic word search processes. Our results identify the anatomical substrates of two main executive processes, revealing that they represent only a specific subpart of previously reported structures. Finally, our results indicate that executive functions depend on several specific, anatomically separable executive processes mainly operating in various parts of the frontal lobes.
Identifiants
pubmed: 39060618
doi: 10.1007/s00415-024-12541-8
pii: 10.1007/s00415-024-12541-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : ZonMw
ID : Vici Grant 918.16.616
Pays : Netherlands
Organisme : ZonMw
ID : 842003011
Pays : Netherlands
Organisme : Direction Générale de l'offre de Soins
ID : DGOS R1/2013/144
Informations de copyright
© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.
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