The Effect of KSK-94, a Dual Histamine H
beige adipocyte
developing obesity
dual histamine H3 and sigma-2 receptor antagonist
white adipose tissue browning
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
01 Jul 2024
01 Jul 2024
Historique:
received:
24
05
2024
revised:
17
06
2024
accepted:
26
06
2024
medline:
27
7
2024
pubmed:
27
7
2024
entrez:
27
7
2024
Statut:
epublish
Résumé
Numerous studies highlight the critical role that neural histamine plays in feeding behavior, which is controlled by central histamine H Visceral adipose tissue was collected from four groups of rats (standard diet + vehicle, palatable diet + vehicle, palatable diet + KSK-94, and palatable diet + bupropion/naltrexone) and subjected to biochemical, histopathological, and immunohistochemical studies. The obtained results clearly indicate that compound KSK-94 prevented the hypertrophy and inflammation of visceral adipose tissue, normalized the levels of leptin, resistin and saved the total reduction capacity of adipose tissue, being more effective than bupropion/naltrexon in these aspects. Moreover, KSK-94 may induce browning of visceral white adipose tissue. Our study suggests that dual compounds with a receptor profile like KSK-94, i.e., targeting histamine H
Sections du résumé
BACKGROUND
BACKGROUND
Numerous studies highlight the critical role that neural histamine plays in feeding behavior, which is controlled by central histamine H
METHODS
METHODS
Visceral adipose tissue was collected from four groups of rats (standard diet + vehicle, palatable diet + vehicle, palatable diet + KSK-94, and palatable diet + bupropion/naltrexone) and subjected to biochemical, histopathological, and immunohistochemical studies.
RESULTS
RESULTS
The obtained results clearly indicate that compound KSK-94 prevented the hypertrophy and inflammation of visceral adipose tissue, normalized the levels of leptin, resistin and saved the total reduction capacity of adipose tissue, being more effective than bupropion/naltrexon in these aspects. Moreover, KSK-94 may induce browning of visceral white adipose tissue.
CONCLUSION
CONCLUSIONS
Our study suggests that dual compounds with a receptor profile like KSK-94, i.e., targeting histamine H
Identifiants
pubmed: 39065709
pii: ph17070858
doi: 10.3390/ph17070858
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Science Center, Poland
ID : 2016/23/B/NZ7/01063.