Comparison between indocyanine green angiography and optical coherence tomography angiography for the detection of nonexudative macular neovascularization.

Age-related macular degeneration Indocyanine green angiography Nonexudative Optical coherence tomography angiography

Journal

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
ISSN: 1435-702X
Titre abrégé: Graefes Arch Clin Exp Ophthalmol
Pays: Germany
ID NLM: 8205248

Informations de publication

Date de publication:
27 Jul 2024
Historique:
received: 21 03 2024
accepted: 22 07 2024
revised: 25 06 2024
medline: 28 7 2024
pubmed: 28 7 2024
entrez: 27 7 2024
Statut: aheadofprint

Résumé

Patients with unilateral treatment-naïve exudative neovascular age-related macular degeneration (nAMD) were examined for the presence of nonexudative macular neovascularization (neMNV) in their fellow eye using a multimodal imaging approach. This is intended to determine the sensitivity of individual imaging methods, namely, indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA). In this retrospective cross-sectional study, ICGA images of the nonexudative eye were analyzed for the presence of plaques. SS-OCTA outer retinal segmentations were evaluated for neovascular flow in en-face scans and/or color-coded flow in B-scans. The findings were matched with a double-layer sign (DLS) or pigment epithelium detachment (PED) on conventional OCT. In total, neMNV was diagnosed in the fellow eye of 40 of 241 patients (17%) using a multimodal imaging approach employing both ICGA and SS-OCTA. 25 eyes (10%) showed neMNV in both modalities, while 7 (3%) were only detected by ICGA and 8 (3%) by OCTA alone. The sensitivities of ICGA therefore were 80% (32/40) and 83% (33/40) for OCTA. Of the 40 eyes with neMNV, OCT revealed DLS in 25/40 (63%) and PED in 17/40 (43%) of the cases. None of the modalities alone could detect all neMNV in the partner eye of Caucasians with unilateral treatment-naïve exudative nAMD. ICGA and OCTA showed comparable sensitivity. The combination of ICGA, OCTA, and OCT provides the most comprehensive screening for this AMD subtype.

Identifiants

DOI: 10.1007/s00417-024-06597-5 PMID: 39066843
pubmed: 39066843
doi: 10.1007/s00417-024-06597-5
pii: 10.1007/s00417-024-06597-5
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Topcon Europe Medical
ID : Topcon Europe Medical

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Stefan Kickinger (S)

Karl Landsteiner Institute for Retinal Research and Imaging, Vienna, Austria.
Department of Ophthalmology, Clinic Landstraße, Vienna Health Care Group, Juchgasse 25, Vienna, 1030, Austria.

Martin Stattin (M)

Karl Landsteiner Institute for Retinal Research and Imaging, Vienna, Austria.
Department of Ophthalmology, Clinic Landstraße, Vienna Health Care Group, Juchgasse 25, Vienna, 1030, Austria.
Department of Ophthalmology, Medical University of Innsbruck, Anichstraße 35, Innsbruck, 6020, Austria.

Anna-Maria Haas (AM)

Karl Landsteiner Institute for Retinal Research and Imaging, Vienna, Austria.
Department of Ophthalmology, Clinic Landstraße, Vienna Health Care Group, Juchgasse 25, Vienna, 1030, Austria.

Daniel Ahmed-Balestra (D)

Karl Landsteiner Institute for Retinal Research and Imaging, Vienna, Austria.
Department of Ophthalmology, Clinic Landstraße, Vienna Health Care Group, Juchgasse 25, Vienna, 1030, Austria.

Michael Jacob (M)

Karl Landsteiner Institute for Retinal Research and Imaging, Vienna, Austria.
Department of Ophthalmology, Clinic Landstraße, Vienna Health Care Group, Juchgasse 25, Vienna, 1030, Austria.

Claus Zehetner (C)

Department of Ophthalmology, Medical University of Innsbruck, Anichstraße 35, Innsbruck, 6020, Austria.

Katharina Krepler (K)

Karl Landsteiner Institute for Retinal Research and Imaging, Vienna, Austria.
Department of Ophthalmology, Clinic Landstraße, Vienna Health Care Group, Juchgasse 25, Vienna, 1030, Austria.

Siamak Ansari-Shahrezaei (S)

Karl Landsteiner Institute for Retinal Research and Imaging, Vienna, Austria. siamak.ansarishahrezaei@gesundheitsverbund.at.
Department of Ophthalmology, Clinic Landstraße, Vienna Health Care Group, Juchgasse 25, Vienna, 1030, Austria. siamak.ansarishahrezaei@gesundheitsverbund.at.
Medical School, Sigmund Freud University Vienna, Campus Prater Freudplatz 3, Vienna, 1020, Austria. siamak.ansarishahrezaei@gesundheitsverbund.at.
Department of Ophthalmology, Medical University of Graz, Graz, Austria. siamak.ansarishahrezaei@gesundheitsverbund.at.
ORCID: 0000-0001-8032-4686

Classifications MeSH