Linezolid induced toxic optic neuropathy in drug resistant tuberculosis-A case series.
Drug toxicity
Linezolid
Optic neuropathy
Tuberculosis
Journal
The Indian journal of tuberculosis
ISSN: 0019-5707
Titre abrégé: Indian J Tuberc
Pays: India
ID NLM: 0373027
Informations de publication
Date de publication:
2024
2024
Historique:
received:
14
11
2022
revised:
15
06
2023
accepted:
22
06
2023
medline:
28
7
2024
pubmed:
28
7
2024
entrez:
27
7
2024
Statut:
ppublish
Résumé
In developing countries like India, Linezolid is widely used for the treatment of Multi drug resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB). Long-term administration of Linezolid is reported to cause toxic optic neuropathy causing bilateral, progressive visual loss in patients. We report case details of three patients on anti-tubercular therapy presented to us with sudden, progressive, painless blurring of vision of both eyes the cause of which was confirmed to be toxic optic neuropathy due to linezolid. Subsequently, cessation of the drug resulted in complete visual recovery in two patients whereas one patient had minimal visual improvement due to secondary optic atrophy. Clinicians and health care workers need to be aware of sight threatening complications of Linezolid.
Identifiants
pubmed: 39067955
pii: S0019-5707(23)00123-3
doi: 10.1016/j.ijtb.2023.06.016
pii:
doi:
Substances chimiques
Linezolid
ISQ9I6J12J
Antitubercular Agents
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
S5-S9Informations de copyright
Copyright © 2023 Tuberculosis Association of India. Published by Elsevier B.V. All rights reserved.