The clinical relevance of MOG antibody testing in cerebrospinal fluid.

Journal

Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278

Informations de publication

Date de publication:
28 Jul 2024
Historique:
revised: 08 07 2024
received: 24 04 2024
accepted: 15 07 2024
medline: 29 7 2024
pubmed: 29 7 2024
entrez: 29 7 2024
Statut: aheadofprint

Résumé

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is diagnosed by serum MOG-immunoglobulin G (MOG-IgG) in association with typical demyelination. 111/1127 patients with paired CSF/serum samples were seropositive for MOG-IgG. Only 7/1016 (0.7%) seronegative patients had CSF-restricted MOG-IgG. While 3/7 patients had longitudinally extensive transverse myelitis, four had a confirmed alternate diagnosis (three multiple sclerosis, one CNS vasculitis). In a national referral setting, CSF-restricted MOG-IgG had a low sensitivity (2.63%, 95%CI 0.55-7.50%) and low positive predictive value (1.97%, 95%CI 0.45-8.13%). We strongly recommend serum as the preferred diagnostic biospecimen, and urge caution in the interpretation of CSF-restricted MOG-IgG in patients without clinico-radiological features consistent with MOGAD.

Identifiants

DOI: 10.1002/acn3.52163 PMID: 39073255
pubmed: 39073255
doi: 10.1002/acn3.52163
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Health and Medical Research Council
ID : GNT2008339
Organisme : Royal Australasian College of Physicians
Organisme : Faculty of Medicine and Health, University of Sydney

Investigateurs

Robert Adam (R)
Jane Andersen (J)
Ian Andrews (I)
Jayne Antony (J)
Patrick Aouad (P)
Monica Badve (M)
Michael H Barnett (MH)
Joshua Barton (J)
Heidi Beadnall (H)
Stefan Blum (S)
Michael Boggild (M)
Fabienne Brilot (F)
Simon Broadley (S)
David A Brown (DA)
Jim Burrow (J)
Helmut Butzkueven (H)
Katherine Buzzard (K)
Ann Bye (A)
Anita Cairns (A)
Sophie Calvert (S)
Fiona Chan (F)
Shabeed Chelakkadan (S)
Melissa Chu (M)
Damian R Clark (DR)
Isabella Cotter (I)
Russell C Dale (RC)
Fionna Dela Cruz (F)
Marzena J Fabis-Pedrini (MJ)
Deborah Field (D)
Anthony Fok (A)
Clare L Fraser (CL)
Victor S C Fung (VSC)
Justin Garber (J)
Serge Geara (S)
Deepak Gill (D)
Sachin Gupta (S)
Todd A Hardy (TA)
Simon Hawke (S)
Andrew P D Henderson (APD)
Niroshan Jeyakumar (N)
Nevin A John (NA)
Dean L Jones (DL)
Hannah F Jones (HF)
Tomas Kalincik (T)
Allan Kermode (A)
Matthew Kiernan (M)
Trevor Kilpatrick (T)
Chris Kneebone (C)
Andrew J Kornberg (AJ)
Mitchell Lawlor (M)
Jeannette Lechner-Scott (J)
Fiona X Z Lee (FXZ)
Magdalena Lerch (M)
Richard J Leventer (RJ)
Vivien Li (V)
Simon Ling (S)
Ganesha Liyanage (G)
Joseph A Lopez (JA)
Kit Kwan Margaret Ma (KKM)
Stephen Malone (S)
Mark P Marriot (MP)
Pamela McCombe (P)
Alan McDougall (A)
Manoj P Menezes (MP)
Vera Merheb (V)
Christina Miteff (C)
Mastura Monif (M)
Gopinath Musuwadi Subramanian (G)
Kristy Nguyen (K)
Ai-Lan Nguyen (AL)
Gina O'Grady (G)
John O'Neill (J)
Robert Ouvrier (R)
Mark Paine (M)
John Parratt (J)
Sekhar Pillai (S)
Jane Prosser (J)
Jessica Qiu (J)
Sudarshini Ramanathan (S)
Stephen Reddel (S)
Molly Reynolds (M)
Sean Ds Riminton (SD)
Izanne Roos (I)
Jennifer Sandbach (J)
Ingrid E Scheffer (IE)
Snehal Shah (S)
Ubaid Shah (U)
Neil Shuey (N)
Adriane Sinclair (A)
Pakeeran Siriratnam (P)
Mark Slee (M)
Claire G Spooner (CG)
Ian Sutton (I)
Sanjay Swaminathan (S)
Esther Tantsis (E)
James Thomas (J)
Terrence Thomas (T)
Julia Thompson (J)
Benjamin P Trewin (BP)
Christopher Troedson (C)
Anneke Van der Walt (A)
Steve Vucic (S)
Justine Wang (J)
Tyson Ware (T)
Richard Webster (R)
Ming Wei Lin (MW)
Owen White (O)
Nigel Wolfe (N)
Wei Yeh (W)
Con Yiannikas (C)
Eppie M Yiu (EM)
Michael Zhong (M)

Informations de copyright

© 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

Références

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Auteurs

Molly Reynolds (M)

Translational Neuroimmunology Group, Kids Neuroscience Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Department of Neurology, Concord Hospital, Sydney, Australia.

Irene Tan (I)

Department of Radiology, Concord Hospital, Sydney, Australia.

Kristy Nguyen (K)

Brain Autoimmunity Group, Kids Neuroscience Centre, Children's Hospital at Westmead, Sydney, Australia.

Vera Merheb (V)

Brain Autoimmunity Group, Kids Neuroscience Centre, Children's Hospital at Westmead, Sydney, Australia.

Fiona X Z Lee (FXZ)

Brain Autoimmunity Group, Kids Neuroscience Centre, Children's Hospital at Westmead, Sydney, Australia.

Benjamin P Trewin (BP)

Translational Neuroimmunology Group, Kids Neuroscience Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Sydney Medical School and Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
ORCID: 0000-0001-6452-6229

Magdalena Lerch (M)

Translational Neuroimmunology Group, Kids Neuroscience Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

Snehal Shah (S)

Department of Neurology, Perth Children's Hospital, University of Western Australia, Perth, Australia.

Nigel Wolfe (N)

Department of Neurology, Blacktown Hospital, Sydney, Australia.

Katherine Buzzard (K)

MS and Neuroimmunology Service, Royal Melbourne Hospital, Melbourne, Australia.

Jeannette Lechner-Scott (J)

Hunter Medical Research Institute, Faculty of Medicine and Public Health, University of Newcastle, Newcastle, Australia.
Department of Neurology, John Hunter Hospital, Newcastle, Australia.

Marzena Fabis-Pedrini (M)

The Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, Australia.
The Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Australia.

Anthony Fok (A)

Department of Neuroscience, Monash Health, Melbourne, Australia.
Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia.

Nevin John (N)

Department of Neuroscience, Monash Health, Melbourne, Australia.
Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia.

Chris Kneebone (C)

Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia.

Con Yiannikas (C)

Inner West Neurology, Burwood, Sydney, Australia.

David A Brown (DA)

ICPMR and Department of Immunopathology, NSW Health Pathology, Westmead Hospital, Westmead, Sydney, Australia.
Clinical Immunology and Allergy Research, Westmead Institute for Medical Research, Westmead, Sydney, Australia.

Allan G Kermode (AG)

The Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, Australia.
The Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Australia.

Stephen Reddel (S)

Department of Neurology, Concord Hospital, Sydney, Australia.
Sydney Medical School and Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

Russell C Dale (RC)

Sydney Medical School and Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Clinical Neuroimmunology Group, Kids Neuroscience Centre, Children's Hospital at Westmead, Sydney, Australia.
TY Nelson Department of Neurology, Children's Hospital at Westmead, Sydney, Australia.
ORCID: 0000-0002-2495-1826

Fabienne Brilot (F)

Brain Autoimmunity Group, Kids Neuroscience Centre, Children's Hospital at Westmead, Sydney, Australia.
School of Medical Science and Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
ORCID: 0000-0002-7025-2276

Sudarshini Ramanathan (S)

Translational Neuroimmunology Group, Kids Neuroscience Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Department of Neurology, Concord Hospital, Sydney, Australia.
Sydney Medical School and Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
ORCID: 0000-0002-0294-9768

Classifications MeSH