Argon pharmacokinetics: measurements in pigs and analysis in humans using a physiologically based pharmacokinetics model.
Journal
Medical gas research
ISSN: 2045-9912
Titre abrégé: Med Gas Res
Pays: Australia
ID NLM: 101564536
Informations de publication
Date de publication:
01 Dec 2024
01 Dec 2024
Historique:
received:
30
03
2023
accepted:
22
01
2024
medline:
29
7
2024
pubmed:
29
7
2024
entrez:
29
7
2024
Statut:
ppublish
Résumé
The primary objective of this study was to investigate the pharmacokinetics of inhaled argon in young pigs using mechanical ventilation. Also a physiologically based model of argon pharmacokinetics (PBPK) is validated with human data for xenon from the literature and the new data from juvenile pigs. The inherent difficulty in performing pharmacokinetics studies of argon makes the use of the PBPK model especially relevant. The model is used to investigate argon pharmacokinetics for adult and neonate applications. Juvenile pigs (n = 4) were anesthetized, submitted to endotracheal intubation, and mechanical ventilation using a conventional ventilator. Argon inhalation was achieved by switching the animal from the first mechanical ventilator (with air/oxygen) to a second one that was supplied with 75% argon and 25% oxygen from premixed gas cylinders. This administration yielded blood samples that were analyzed using a quadrupole based technique for determining argon concentration. The range of blood:gas partition coefficient corresponding to the average measured Cmax of 190-872 μM is 0.005-0.022. Based on the average curve, T1/2= 75 seconds. The PBPK is shown to be in general agreement with the experimental data in pigs. Inhaled argon administration exhibited an on-off nature such that AUC was proportional to administration time. Confidence in the PBPK model and the remarkably robust and stable on-off nature of argon pharmacokinetics, notwithstanding intersubject variability and comorbidity, suggests that inhaled argon could readily be applied to any treatment regime.
Identifiants
pubmed: 39073329
doi: 10.4103/mgr.mgr_20_23
pii: 01612956-202414040-00011
doi:
Substances chimiques
Argon
67XQY1V3KH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
206-212Informations de copyright
Copyright © 2024 Copyright: © 2024 Medical Gas Research.
Références
Zafonte RD, Wang L, Arbelaez CA, Dennison R, Teng YD. Medical gas therapy for tissue, organ, and CNS protection: a systematic review of effects, mechanisms, and challenges. Adv Sci (Weinh). 2022;9:e2104136.
Scheid S, Lejarre A, Wollborn J, Buerkle H, Goebel U, Ulbrich F. Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect. Neural Regen Res. 2023;18:1371-1377.
Zhang J, Liu W, Bi M, Xu J, Yang H, Zhang Y. Noble gases therapy in cardiocerebrovascular diseases: the novel stars? Front Cardiovasc Med. 2022;9:802783.
Schneider FI, Krieg SM, Lindauer U, Stoffel M, Ryang YM. Neuroprotective effects of the inert gas argon on experimental traumatic brain injury in vivo with the controlled cortical impact model in mice. Biology (Basel). 2022;11:158.
Silachev DN, Boeva EA, Yakupova EI, Positive neuroprotective effect of argon inhalation after photochemically induced ischemic stroke model in rats. Bull Exp Biol Med. 2023;176:143-149.
Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism. Chem Res Toxicol. 2008;21:129-137.
Katz I, Murdock J, Palgen M, Pype J, Caillibotte G. Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model. Med Gas Res. 2015;5:8.
Lemaire J, Heninger M, Louarn E, Argon pharmacokinetics: a solubility measurement technique. Med Gas Res. 2023;13:208-211.
Schaefer MS, Piper T, Geyer H, Xenon elimination kinetics following brief exposure. Drug Test Anal. 2017;9:666-670.
Katz I, Milet A, Chalopin M, Farjot G. Numerical analysis of mechanical ventilation using high concentration medical gas mixtures in newborns. Med Gas Res. 2019;9:213-220.
Katz I, Chen J, Duong K, Dose variability of supplemental oxygen therapy with open patient interfaces based on in vitro measurements using a physiologically realistic upper airway model. Respir Res. 2019;20:149.
George SC, Hlastala MP. Airway gas exchange and exhaled biomarkers. Compr Physiol. 2011;1:1837-1859.
Katz I, Murdock J, Palgen M, Farjot G. A physiologically based model for denitrogenation kinetics. Med Gas Res. 2017;7:256-259.
Hendrickx J, Peyton P, Carette R, De Wolf A. Inhaled anaesthetics and nitrous oxide: complexities overlooked: things may not be what they seem. Eur J Anaesthesiol. 2016;33:611-619.
Katz I, Palgen M, Murdock J, Martin AR, Farjot G, Caillibotte G. Gas transport during in vitro and in vivo preclinical testing of inert gas therapies. Med Gas Res. 2016;6:14-19.
Theoretical context-sensitive elimination times for inhalation anaesthetics. Br J Anaesth. 2010;104:648-655.
Filser JG, Schmidbauer R, Rampf F, Baur CM, Pütz C, Csanády GA. Toxicokinetics of inhaled propylene in mouse, rat, and human. Toxicol Appl Pharmacol. 2000;169:40-51.
Csanády GA, Filser JG. A physiological toxicokinetic model for inhaled propylene oxide in rat and human with special emphasis on the nose. Toxicol Sci. 2007;95:37-62.
Extrapolation of physiological parameters for physiologically based simulation models. Toxicol Lett. 1995;79:77-86.
Sackner MA, Atkins N, Goldberg J, Segel N, Zarzecki S, Wanner A. Pulmonary arterial blood volume and tissue volume in man and dog. Circ Res. 1974;34:761-769.
Collis T, Devereux RB, Roman MJ, Relations of stroke volume and cardiac output to body composition: the strong heart study. Circulation. 2001;103:820-825.
Haddad S, Restieri C, Krishnan K. Characterization of age-related changes in body weight and organ weights from birth to adolescence in humans. J Toxicol Environ Health A. 2001;64:453-464.
Price K, Haddad S, Krishnan K. Physiological modeling of age-specific changes in the pharmacokinetics of organic chemicals in children. J Toxicol Environ Health A. 2003;66:417-433.
Fiserova-Bergerova V, Diaz ML. Determination and prediction of tissue-gas partition coefficients. Int Arch Occup Environ Health. 1986;58:75-87.
Rosenthal MS, Nickles RJ. Selected noble-gas partition coefficients. Phys Med Biol. 1985;30:945-950.
Tomonaga Y, Brennwald MS, Livingstone DM, Tomonaga G, Kipfer R. Determination of natural in vivo noble-gas concentrations in human blood. PLoS One. 2014;9:e96972.
Nalos M, Wachter U, Pittner A, Georgieff M, Radermacher P, Froeba G. Arterial and mixed venous xenon blood concentrations in pigs during wash-in of inhalational anaesthesia. Br J Anaesth. 2001;87:497-498.
Levitt DG, Schnider TW. Human physiologically based pharmacokinetic model for propofol. BMC Anesthesiol. 2005;5:4.
Langø T, Mørland T, Brubakk AO. Diffusion coefficients and solubility coefficients for gases in biological fluids and tissues: a review. Undersea Hyperb Med. 1996;23:247-272.
Ntalouka MP, Arnaoutoglou E, Tzimas P. Postoperative cognitive disorders: an update. Hippokratia. 2018;22:147-154.
World Anti-Doping Agency. The world anti-doping code international standard. Prohibited list January 2017. https://www.wada-ama.org/sites/default/files/resources/files/2016-09-29_-_wada_prohibited_list_2017_eng_final.pdf. Accessed March30, 2021.
World Anti-Doping Agency. The world anti-doping code international standard. Prohibited list 2024. https://www.wada-ama.org/sites/default/files/2023-09/2024list_en_final_22_september_2023.pdf. Accessed March1, 2024.