Impact of Nodular Calcifications in the Aortic Annulus and Left Ventricular Outflow Tract on TAVI Outcome with New-Generation Devices.

Background

The impact of nodular calcifications in left ventricular outlow tract (LVOT) and aortic annulus on the procedural outcome of transcatheter aortic valve implantation (TAVI) with new-generation devices is yet to be elucidated. Similarly, computational simulations may provide a novel insight into the biomechanical features of TAVI devices and their interaction with nodular calcifications.

Methods

This retrospective single-center study included 232 patients submitted to TAVI with Evolut-R (53.4%), Portico (33.6%) and Lotus (13.0%) devices with available preoperative computed tomography (CT) angiography and evidence of nodular calcifications in aortic annulus and/or LVOT. Calcification severity was defined

Results

At least moderate calcifications were found in 123 (53.0%) patients, with no sex differences. Among the

Conclusions

At least moderate nodular calcifications in the annulus/LVOT region significantly affected TAVI outcome, as they were independent predictors of device success. Lotus and Portico seemed to perform better than Evolut-R as for device success and

Informations de copyright

Copyright: © 2022 The Author(s). Published by IMR Press.

Déclaration de conflit d'intérêts

Francesco Bedogni is consultant for Medtronic, Abbott, and Boston Scientific; Nedy Brambilla and Luca Testa are consultants for Abbott and Boston Scientific. The other authors declare no conflict of interest.