Implication of the Annexin 1/FPR axis in leishmanial exosome-mediated
Annexin A1
FPR2
Leishmania
cutaneous leishmaniasis
exosomes
extracellular vesicles
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
21
05
2024
accepted:
01
07
2024
medline:
30
7
2024
pubmed:
30
7
2024
entrez:
30
7
2024
Statut:
epublish
Résumé
Exosomes produced by the protozoan parasite Murine and We established that ANXA1 deficiency prohibits LeishEXO-mediated pathogenesis and myeloid cell infection, with minimal alterations to adaptive and innate immune phenotypes. FPR2 blockade with WRW4 similarly inhibited leishmanial hyperpathogenesis, while direct activation of FPRs with WKYMVm enhanced infection and recapitulated the LeishEXO-mediated phenotype. This research describes LeishEXO's utilization of the ANXA1/FPR axis to facilitate parasitic internalization and pathogenesis, which may be leveraged in the development of therapeutics for leishmaniasis.
Identifiants
pubmed: 39076982
doi: 10.3389/fimmu.2024.1436151
pmc: PMC11284082
doi:
Substances chimiques
Annexin A1
0
Receptors, Formyl Peptide
0
annexin A1, mouse
0
formyl peptide receptor 2, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1436151Informations de copyright
Copyright © 2024 da Silva Lira Filho, Lafleur, Alvarez, Piccirillo and Olivier.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.