Cardiac Magnetic Resonance Features of Fabry Disease: From Early Diagnosis to Prognostic Stratification.

In the past few years, the wide application of cardiac magnetic resonance (CMR) significantly changed the approach to the study of cardiac involvement in Fabry Disease (FD). The possibility to perform non-invasive tissue characterization, including new sequences such as T1/T2 mapping, offered a powerful tool for differential diagnosis with other forms of left ventricular hypertrophy. In patients with confirmed diagnosis of FD, CMR is the most sensitive non-invasive technique for early detection of cardiac involvement and it provides new insight into the evolution of cardiac damage, including gender-specific features. Finally, CMR multiparametric detection of subtle changes in cardiac morphology, function and tissue composition is potentially useful for monitoring the efficacy of specific treatment over time. This paper aims to provide a comprehensive review of current knowledge regarding the application of CMR in FD cardiac involvement and its clinical implication.

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Copyright: © 2022 The Author(s). Published by IMR Press.

Déclaration de conflit d'intérêts

AC: Honoraria for presentations and board meetings from Amicus Therapeutics, Sanofi-Genzyme and Shire. Research grant from Amicus Therapeutics. MP: speaker and advisory board honoraria, and travel support from Sanofi-Genzyme, Amicus Therapeutics and Shire. AD, GP, LT, SP, MC: The authors declare no conflict of interest. FG: travel sponsor from Genzyme, Shire and Amicus, honoraria speaker for Takeda-Shire and Genzyme. ML: Honoraria for presentations from Shire. MP is serving as one of the Editorial Board members/Guest editors of this journal. We declare that MP had no involvement in the peer review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to Grigorios Korosoglou and Sophie Mavrogeni.