Unlocking the potential of higher-molecular-weight 5-HT
ADMET properties
Docking
G protein-coupled receptors
Gene expression assay
MTS assay
Molecular modelling
Serotonin receptor 5-HT(7)
in vitro experiments
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
24 Jul 2024
24 Jul 2024
Historique:
received:
20
05
2024
revised:
10
07
2024
accepted:
22
07
2024
medline:
31
7
2024
pubmed:
31
7
2024
entrez:
30
7
2024
Statut:
aheadofprint
Résumé
An increasing number of drugs introduced to the market and numerous repositories of compounds with confirmed activity have posed the need to revalidate the state-of-the-art rules that determine the ranges of properties the compounds should possess to become future drugs. In this study, we designed a series of two chemotypes of aryl-piperazine hydantoin ligands of 5-HT
Identifiants
pubmed: 39079393
pii: S0045-2068(24)00573-X
doi: 10.1016/j.bioorg.2024.107668
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107668Informations de copyright
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.