Cornerstones and divergencies in the implementation and use of liver hypertrophy techniques: results from a nationwide survey for the set-up of the prospective registry.

Hypertrophy techniques Liver failure Liver surgery Morbidity Survey

Journal

Updates in surgery
ISSN: 2038-3312
Titre abrégé: Updates Surg
Pays: Italy
ID NLM: 101539818

Informations de publication

Date de publication:
30 Jul 2024
Historique:
received: 28 05 2024
accepted: 08 07 2024
medline: 31 7 2024
pubmed: 31 7 2024
entrez: 30 7 2024
Statut: aheadofprint

Résumé

The aim of this national survey on liver hypertrophy techniques was to track the trends of their use and implementation in Italy and to detect analogies and heterogeneities among centers. In December 2022, Italian centers with liver resection activity were specifically contacted and asked to fill an online questionnaire composed of 6 sections including a total of 51 questions. 46 Italian centers filled the questionnaire. The proportion of major/total number of liver resections was 27% and the use of hypertrophy techniques was required in 6,2% of cases. The most frequent reason of drop out was disease progression in 58.5% of cases. Most frequently used techniques were PVE and ALPPS with an increasing use of hepatic venous deprivation (HVD). Heterogeneous answers were provided regarding the cutoff values to indicate the need for hypertrophy techniques. Criteria to allocate a patient to different hypertrophy techniques are not standardized. The use of hypertrophy techniques is deep-rooted in Italy, documenting the established value of their role in improving resectability rate. While an evolution of techniques is detectable, still significant heterogeneity is perceived in terms of cutoff values, indications and managing protocols.

Sections du résumé

BACKGROUND BACKGROUND
The aim of this national survey on liver hypertrophy techniques was to track the trends of their use and implementation in Italy and to detect analogies and heterogeneities among centers.
METHODS METHODS
In December 2022, Italian centers with liver resection activity were specifically contacted and asked to fill an online questionnaire composed of 6 sections including a total of 51 questions.
RESULTS RESULTS
46 Italian centers filled the questionnaire. The proportion of major/total number of liver resections was 27% and the use of hypertrophy techniques was required in 6,2% of cases. The most frequent reason of drop out was disease progression in 58.5% of cases. Most frequently used techniques were PVE and ALPPS with an increasing use of hepatic venous deprivation (HVD). Heterogeneous answers were provided regarding the cutoff values to indicate the need for hypertrophy techniques. Criteria to allocate a patient to different hypertrophy techniques are not standardized.
CONCLUSIONS CONCLUSIONS
The use of hypertrophy techniques is deep-rooted in Italy, documenting the established value of their role in improving resectability rate. While an evolution of techniques is detectable, still significant heterogeneity is perceived in terms of cutoff values, indications and managing protocols.

Identifiants

pubmed: 39080095
doi: 10.1007/s13304-024-01945-w
pii: 10.1007/s13304-024-01945-w
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Italian Society of Surgery (SIC).

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Auteurs

Francesca Ratti (F)

Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, Milan, Italy. ratti.francesca@hsr.it.
Vita-Salute San Raffaele University, Vita-Salute San Raffaele University, Milano, Italy. ratti.francesca@hsr.it.

Matteo Serenari (M)

Hepato-Biliary Surgery and Transplant Unit, IRCCS, Azienda Ospedaliero-Universitaria Di Bologna, Sant'Orsola-Malpighi Hospital, Bologna, Italy.
Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Alfonso Avolio (A)

General Surgery and Liver Transplantation, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Giacomo Batignani (G)

Department of Experimental and Clinical Medicine, Hepatobiliary Pancreatic Surgery, University of Florence, Florence, Italy.

Ugo Boggi (U)

Department of Surgery, University Hospital of Pisa, Pisa, Italy.

Alberto Brolese (A)

Department of General Surgery and Hepato-Pancreato-Biliary (HPB) Unit-APSS, Trento, Italy.

Lucio Caccamo (L)

Unit of General Surgery and Liver Transplantation, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Andrea Celotti (A)

Department of Surgery, ASST Cremona, Cremona, CR, Italy.

Umberto Cillo (U)

General Surgery 2-Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, Padua, Italy.

Nicola Cinardi (N)

Hepato-Pancreato-Biliary (HPB) Surgery Unit Azienda Di Rilevanza Nazionale e Alta Specializzazione (ARNAS) Garibaldi-PO "Nesima", 95100, Catania, Italy.

Christian Cotsoglou (C)

General Surgery Unit, IRCCS San Gerardo Dei Tintori, Monza, Italy.

Raffaele Dalla Valle (R)

Hepatobiliary Surgery Unit Department of Medicine and Surgery, University of Parma, Parma, Italy.

Luciano De Carlis (L)

Department of General Surgery and Transplantation, School of Medicine, University of Milano-Bicocca, Niguarda Hospital, Milan, Italy.

Paolo De Simone (P)

Division of Hepatic Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy.

Fabrizio Di Benedetto (F)

Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.

Giorgio Ercolani (G)

Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
General and Oncology Surgery, Morgagni-Pierantoni Hospital, Ausl Romagna, Forlì, Italy.

Giuseppe Maria Ettorre (GM)

Department of Surgery, San Camillo Forlanini Hospital, Rome, Italy.

Massimo Fedi (M)

Hepatobiliary Surgery Unit, USL Toscana Centro-San Jacopo Hospital, Pistoia, Italy.

Alessandro Ferrero (A)

Department of Surgery, Mauriziano Hospital, Turin, Italy.

Antonio Giuliani (A)

Unit of General Surgery, San Giuseppe Moscati Hospital, Aversa, Italy.

Felice Giuliante (F)

Hepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy.

Gian Luca Grazi (GL)

Department of Experimental and Clinical Medicine, Hepatobiliary Pancreatic Surgery, University of Florence, Florence, Italy.

Salvatore Gruttadauria (S)

Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Istituto Di Ricovero E Cura a Carattere Scientifico-Istituto Mediterraneo Per I Trapianti E Terapie Ad Alta Specializzazione (IRCCS-ISMETT), 90127, Palermo, Italy.
Department of Surgery and Medical and Surgical Specialties, University of Catania, 95124, Catania, Italy.

Alfredo Guglielmi (A)

Department of Surgery, Dentistry, Gynecology and Pediatrics, Division of General and Hepatobiliary Surgery, University of Verona, G.B. Rossi University Hospital, Verona, Italy.

Francesco Izzo (F)

Division of Surgical Oncology, Hepatobiliary Unit, Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale" Napoli, Naples, Italy.

Quirino Lai (Q)

General Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161, Rome, Italy.

Dario Lorenzin (D)

General Surgery Clinic and Liver Transplant Center, University Hospital of Udine, Udine, Italy.

Marcello Maestri (M)

Division of General Surgery 1, Department of Surgery, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.

Marco Massani (M)

Regional Center for HPB Surgery, Regional Hospital of Treviso, Treviso, Italy.

Vincenzo Mazzaferro (V)

Department of Surgery, Division of HPB Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori Di Milano, Milan, Italy.
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

Riccardo Memeo (R)

Department of Hepato-Pancreato-Biliary Surgery, "F. Miulli" General Regional Hospital, Acquaviva Delle Fonti, Bari, Italy.
Department of Medicine and Surgery, LUM University, Casamassima, Bari, Italy.

Bruno Nardo (B)

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.

Nazario Portolani (N)

Department of Clinical and Experimental Sciences, Surgical Clinic, University of Brescia, Brescia, Italy.

Matteo Ravaioli (M)

Hepato-Biliary Surgery and Transplant Unit, IRCCS, Azienda Ospedaliero-Universitaria Di Bologna, Sant'Orsola-Malpighi Hospital, Bologna, Italy.
Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Aldo Rocca (A)

Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.
HPB Surgery Unit, Pineta Grande Hospital, 81030, Castel Volturno, Italy.

Renato Romagnoli (R)

General Surgery 2U-Liver Transplant Unit, Molinette Hospital, Azienda Ospedaliero Universitaria Città Della Salute E Della Scienza Di Torino, Università Di Torino, Turin, Italy.

Fabrizio Romano (F)

School of Medicine and Surgery, University of Milan Bicocca, HPB Surgery, Fondazione IRCCS San Gerardo, Monza, Italy.

Edoardo Saladino (E)

Oncological Surgical Unit, Papardo Hospital, Messina, Italy.

Giuseppe Tisone (G)

Department of Surgical Sciences and Medical Sciences, University of Rome-Tor Vergata, Rome, Italy.

Roberto Troisi (R)

Division of HPB, Minimally Invasive and Robotic Surgery, Transplantation Service, Federico II University Hospital Naples, Naples, Italy.

Luigi Veneroni (L)

General Surgery Division, Ospedale Infermi, Rimini, Italy.

Giovanni Vennarecci (G)

Department of Hepatobiliary and Liver Transplantation Surgery, A.O.R.N. Cardarelli, Naples, Italy.

Luca Viganò (L)

Division of Surgery, Humanitas Gavazzeni Hospital, Bergamo, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.

Giuseppe Viola (G)

Chirurgia Generale Azienda Ospedaliera Card. G. Panico, Tricase, Italy.

Marco Vivarelli (M)

HPB Surgery and Transplantation Unit, Department of Clinical and Experimental Medicine, Polytechnic University of Marche, Ancona, Italy.

Giacomo Zanus (G)

Department of Surgery, Oncology and Gastroenterology - DISCOG, University of Padua, Padua, Italy.

Luca Aldrighetti (L)

Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Vita-Salute San Raffaele University, Vita-Salute San Raffaele University, Milano, Italy.

Elio Jovine (E)

Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Department of General Surgery, IRCCS, Azienda Ospedaliero-Universitaria Di Bologna, Maggiore Hospital, Bologna, Italy.

Classifications MeSH