Early risk predictors of acute kidney injury and short-term survival during Impella support in cardiogenic shock.
Acute kidney injury (AKI)
Cardiogenic shock
Left ventricular Impella
Predictors of AKI
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 Jul 2024
30 Jul 2024
Historique:
received:
31
03
2024
accepted:
23
07
2024
medline:
31
7
2024
pubmed:
31
7
2024
entrez:
30
7
2024
Statut:
epublish
Résumé
Acute kidney injury (AKI) is one of the most frequent and prognostic-relevant complications of cardiogenic shock (CS) complicating myocardial infarction (MI). Mechanical circulatory assist devices (MCS) like left ventricular Impella microaxial pump have increasingly been used in the last decade for stabilization of hemodynamics in those patients. Moreover, a protective effect of Impella on renal organ perfusion could recently be demonstrated. However, data identifying early risk predictors for developing AKI during Impella support in CS are rare. Data of hemodynamics and renal function from 50 Impella patients (January 2020 and February 2022) with MI-related CS (SCAI stage C), were retrospectively analyzed using e.g. multivariate logistic regression analysis as well as Kaplan-Meier curves and Cox regression analysis. 30 patients (60%) developed AKI. Central venous pressure as an indicator for venous congestion (OR 1.216, p = 0.02), GFR at admission indicating existing renal damage (OR 0.928, p = 0.002), and reduced central venous oxygen saturation (SvO
Identifiants
pubmed: 39080441
doi: 10.1038/s41598-024-68376-w
pii: 10.1038/s41598-024-68376-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17484Informations de copyright
© 2024. The Author(s).
Références
Samsky, M. D. et al. Cardiogenic shock after acute myocardial infarction: A review. JAMA 326(18), 1840–1850 (2021).
doi: 10.1001/jama.2021.18323
pubmed: 34751704
pmcid: 9661446
Thiele, H., Ohman, E. M., de Waha-Thiele, S., Zeymer, U. & Desch, S. Management of cardiogenic shock complicating myocardial infarction: An update 2019. Eur. Heart J. 40(32), 2671–2683 (2019).
doi: 10.1093/eurheartj/ehz363
pubmed: 31274157
Tarvasmäki, T. et al. Acute kidney injury in cardiogenic shock: Definitions, incidence, haemodynamic alterations, and mortality. Eur. J. Heart Fail. 20(3), 572–581 (2018).
doi: 10.1002/ejhf.958
pubmed: 28960633
Mezhonov, E. M., Vialkina, I. A., Vakulchik, K. A. & Shalaev, S. V. Acute kidney injury in patients with ST-segment elevation acute myocardial infarction: Predictors and outcomes. Saudi J. Kidney Dis. Transpl. 32(2), 318–327 (2021).
doi: 10.4103/1319-2442.335442
pubmed: 35017324
Cosentino, N. et al. Acute kidney injury and in-hospital mortality in patients with ST-elevation myocardial infarction of different age groups. Int. J. Cardiol. 344, 8–12 (2021).
doi: 10.1016/j.ijcard.2021.09.023
pubmed: 34537309
Vallabhajosyula, S. et al. Temporal trends, predictors, and outcomes of acute kidney injury and hemodialysis use in acute myocardial infarction-related cardiogenic shock. PLoS ONE 14(9), e0222894 (2019).
doi: 10.1371/journal.pone.0222894
pubmed: 31532793
pmcid: 6750602
Karatolios, K. et al. Impella support compared to medical treatment for post-cardiac arrest shock after out of hospital cardiac arrest. Resuscitation 126, 104–110 (2018).
doi: 10.1016/j.resuscitation.2018.03.008
pubmed: 29522829
Lüsebrink, E. et al. Percutaneous transvalvular microaxial flow pump support in cardiology. Circulation 145(16), 1254–1284 (2022).
doi: 10.1161/CIRCULATIONAHA.121.058229
pubmed: 35436135
Patsalis, N. et al. Renal protection and hemodynamic improvement by impella microaxial pump in patients with cardiogenic shock. J. Clin. Med. 11(22), 6817 (2022).
doi: 10.3390/jcm11226817
pubmed: 36431294
pmcid: 9698353
Naidu, S. S. et al. SCAI SHOCK stage classification expert consensus update: A review and incorporation of validation studies: This statement was endorsed by the American College of Cardiology (ACC), American College of Emergency Physicians (ACEP), American Heart Association (AHA), European Society of Cardiology (ESC) Association for Acute Cardiovascular Care (ACVC), International Society for Heart and Lung Transplantation (ISHLT), Society of Critical Care Medicine (SCCM), and Society of Thoracic Surgeons (STS) in December 2021. J. Am. Coll. Cardiol. 79(9), 933–946 (2022).
doi: 10.1016/j.jacc.2022.01.018
pubmed: 35115207
Kidney Disease, Improving Global Outcomes (KDIGO). Kidney Int. Suppl. 2, 19–36 (2012).
Sims, A. J., Hussein, H. K., Prabhu, M. & Kanagasundaram, N. S. Are surrogate assumptions and use of diuretics associated with diagnosis and staging of acute kidney injury after cardiac surgery?. Clin. J. Am. SocNephrol. 7(1), 15–23 (2012).
doi: 10.2215/CJN.05360611
Siew, E. D. & Matheny, M. E. Choice of reference serum creatinine in defining acute kidney injury. Nephron 131(2), 107–112 (2015).
doi: 10.1159/000439144
pubmed: 26332325
Bellomo, R., Ronco, C., Kellum, J. A., Mehta, R. L. & Palevsky, P. Acute Dialysis Quality Initiative Workgroup: Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the second international consensus conference of the acute dialysis quality initiative (ADQI) group. Crit. Care 8, R204–R212 (2004).
doi: 10.1186/cc2872
pubmed: 15312219
pmcid: 522841
National Kidney Foundation K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease. Evaluation, classification and stratification. Am. J. Kidney Dis. 39(2 Suppl 1), S76–S92 (2002).
Kidney International Supplements (2013) 3, 4.
Fuernau, G. et al. Prognostic impact of established and novel renal function biomarkers in myocardial infarction with cardiogenic shock: A biomarker substudy of the IABP-SHOCK II-trial. Int. J. Cardiol. 191, 159–166 (2015).
doi: 10.1016/j.ijcard.2015.04.242
pubmed: 25965624
Werdan, K., Ruß, M., Buerke, M., Delle-Karth, G., Geppert, A., Schöndube, F. A., German Cardiac Society, German Society of Intensive Care and Emergency Medicine, German Society for Thoracic and Cardiovascular Surgery (Austrian Society of Internal and General Intensive Care Medicine; German Interdisciplinary Association of Intensive Care and Emergency Medicine; Austrian Society of Cardiology; German Society of Anaesthesiology and Intensive Care Medicine; German Society of Preventive Medicine and Rehabilitation. Cardiogenic shock due to myocardial infarction: diagnosis, monitoring and treatment: a German-Austrian S3 Guideline. DtschArztebl Int. 109(19), 343–351 (2012).
Harjola, V. P. et al. Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur. J. Heart Fail. 19(7), 821–836 (2017).
doi: 10.1002/ejhf.872
pubmed: 28560717
Calfee, C. S. & Matthay, M. A. Clinical immunology: Culprits with evolutionary ties. Nature 464(7285), 41–42 (2010).
doi: 10.1038/464041a
pubmed: 20203598
pmcid: 2857339
Rudiger, A. Understanding cardiogenic shock. Eur. J. Heart Fail. 17(5), 466–467 (2015). https://doi.org/10.1002/ejhf.265 . Erratum in: Eur. J. Heart Fail. 17(6), 639 (2015).
Nijst, P. et al. The pathophysiological role of interstitial sodium in heart failure. J. Am. Coll. Cardiol. 65(4), 378–388 (2015).
doi: 10.1016/j.jacc.2014.11.025
pubmed: 25634838
Marti, C. N. et al. Endothelial dysfunction, arterial stiffness, and heart failure. J. Am. Coll. Cardiol. 60(16), 1455–1469 (2012).
doi: 10.1016/j.jacc.2011.11.082
pubmed: 22999723
Payen, D. et al. A positive fluid balance is associated with a worse outcome in patients with acute renal failure. Crit. Care 12(3), 74 (2008).
doi: 10.1186/cc6916
Sheikh, O., Nguyen, T., Bansal, S. & Prasad, A. Acute kidney injury in cardiogenic shock: A comprehensive review. Catheter Cardiovasc. Interv. 98, E91–E105 (2021).
doi: 10.1002/ccd.29141
pubmed: 32725874
McCallum, W. & Sarnak, M. J. Cardiorenal syndrome in the hospital. Clin. J. Am. Soc. Nephrol. 18(7), 933–945 (2023).
doi: 10.2215/CJN.0000000000000064
pubmed: 36787124
pmcid: 10356127
Andrei, S., Bahr, P. A., Nguyen, M., Bouhemad, B. & Guinot, P. G. Prevalence of systemic venous congestion assessed by Venous Excess Ultrasound Grading System (VExUS) and association with acute kidney injury in a general ICU cohort: a prospective multicentric study. Crit. Care 27(1), 224 (2023).
doi: 10.1186/s13054-023-04524-4
pubmed: 37291662
pmcid: 10249288
D’Marco, L. Congestive nephropathy. Int. J. Environ. Res. Public Health 19(5), 2499 (2022).
doi: 10.3390/ijerph19052499
pubmed: 35270191
pmcid: 8909002
Palazzuoli, A. et al. Chronic kidney disease and worsening renal function in acute heart failure: Different phenotypes with similar prognostic impact?. Eur. Heart J. Acute Cardiovasc. Care 5(8), 534–548 (2016).
doi: 10.1177/2048872615589511
pubmed: 26045513
van den Akker, J. P. C., Bakker, J., Groeneveld, A. B. J. & den Uil, C. A. Risk indicators for acute kidney injury in cardiogenic shock. J. Crit. Care 50, 11–16 (2019).
doi: 10.1016/j.jcrc.2018.11.004
pubmed: 30465893
Legrand, M., Mebazaa, A., Ronco, C. & Januzzi, J. L. Jr. When cardiac failure, kidney dysfunction, and kidney injury intersect in acute conditions: The case of cardiorenal syndrome. Crit. Care Med. 42(9), 2109–2117 (2014).
doi: 10.1097/CCM.0000000000000404
pubmed: 24810531
Mullens, W. et al. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J. Am. Coll. Cardiol. 53(7), 589–596 (2009).
doi: 10.1016/j.jacc.2008.05.068
pubmed: 19215833
pmcid: 2856960
Lüsebrink, E. et al. Percutaneous transvalvular microaxial flow pump support in cardiology. Circulation 145(16), 1254–1284 (2022).
doi: 10.1161/CIRCULATIONAHA.121.058229
pubmed: 35436135
Upadhyaya, V. D. et al. Outcomes of renal function in cardiogenic shock patients with or without mechanical circulatory support. J. Clin. Med. Res. 13(5), 283–292 (2021).
doi: 10.14740/jocmr4449
pubmed: 34104280
pmcid: 8166292
Flaherty, M. P. et al. Hemodynamic support with a microaxial percutaneous left ventricular assist device (Impella) protects against acute kidney injury in patients undergoing high-risk percutaneous coronary intervention. Circ. Res. 120(4), 692–700 (2017).
doi: 10.1161/CIRCRESAHA.116.309738
pubmed: 28073804
Singer, M. et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315(8), 801–810 (2016).
doi: 10.1001/jama.2016.0287
pubmed: 26903338
pmcid: 4968574
Nohria, A. et al. Clinical assessment identifies hemodynamic profiles that predict outcomes in patients admitted with heart failure. J. Am. Coll. Cardiol. 41(10), 1797–1804 (2003).
doi: 10.1016/S0735-1097(03)00309-7
pubmed: 12767667
Mullens, W. & Nijst, P. Cardiac output and renal dysfunction: Definitely more than impaired flow. J. Am. Coll. Cardiol. 67, 2209–2212 (2016).
doi: 10.1016/j.jacc.2016.03.537
pubmed: 27173031
Hanberg, J. S. et al. Reduced cardiac index is not the dominant driver of renal dysfunction in heart failure. J. Am. Coll. Cardiol. 67, 2199–2208 (2016).
doi: 10.1016/j.jacc.2016.02.058
pubmed: 27173030
pmcid: 4867078
Chatzis, G. et al. Early Impella support in postcardiac arrest cardiogenic shock complicating acute myocardial infarction improves short- and long-term survival. Crit. Care Med. 49(6), 943–955 (2021).
doi: 10.1097/CCM.0000000000004915
pubmed: 33729726