Differently increased volumes of multiple brain areas in

2-hydroxypropyl-β-cyclodextrin NPC1 brain areas fresh volumes lipid storage disorder miglustat mouse treatment

Journal

Frontiers in neuroanatomy
ISSN: 1662-5129
Titre abrégé: Front Neuroanat
Pays: Switzerland
ID NLM: 101477943

Informations de publication

Date de publication:
2024
Historique:
received: 10 05 2024
accepted: 01 07 2024
medline: 31 7 2024
pubmed: 31 7 2024
entrez: 31 7 2024
Statut: epublish

Résumé

Niemann-Pick disease type C1 (NPC1, MIM 257220) is a heritable lysosomal storage disease characterized by a progressive neurological degeneration that causes disability and premature death. A murine model of In order to evaluate alterations of different brain areas caused by pharmacotherapy, fresh volumes (volumes calculated from the volumes determined from paraffin embedded brain slices) of various brain structures in sham- and drug-treated wild type and mutant mice were measured using stereological methods. In the wild type mice, the volumes of investigated brain areas were not significantly altered by either therapy. Compared with the respective wild types, fresh volumes of specific brain areas, which were significantly reduced in sham-treated Volumes of brain areas of

Sections du résumé

Background UNASSIGNED
Niemann-Pick disease type C1 (NPC1, MIM 257220) is a heritable lysosomal storage disease characterized by a progressive neurological degeneration that causes disability and premature death. A murine model of
Methods UNASSIGNED
In order to evaluate alterations of different brain areas caused by pharmacotherapy, fresh volumes (volumes calculated from the volumes determined from paraffin embedded brain slices) of various brain structures in sham- and drug-treated wild type and mutant mice were measured using stereological methods.
Results UNASSIGNED
In the wild type mice, the volumes of investigated brain areas were not significantly altered by either therapy. Compared with the respective wild types, fresh volumes of specific brain areas, which were significantly reduced in sham-treated
Discussion UNASSIGNED
Volumes of brain areas of

Identifiants

DOI: 10.3389/fnana.2024.1430790 PMID: 39081805 PMC: PMC11286580
pubmed: 39081805
doi: 10.3389/fnana.2024.1430790
pmc: PMC11286580
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1430790

Informations de copyright

Copyright © 2024 Antipova, Heimes, Seidel, Schulz, Schmitt, Holzmann, Rolfs, Bidmon, González de San Román Martín, Huesgen, Amunts, Keiler, Hammer, Witt and Wree.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Veronica Antipova (V)

Institute of Anatomy, Rostock University Medical Center, Rostock, Germany.
Division of Macroscopic and Clinical Anatomy, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.

Diana Heimes (D)

Institute of Anatomy, Rostock University Medical Center, Rostock, Germany.
Department of Oral and Maxillofacial Surgery, University Medical Center Mainz, Mainz, Germany.

Katharina Seidel (K)

Institute of Anatomy, Rostock University Medical Center, Rostock, Germany.
Klinik für Frauenheilkunde und Geburtshilfe, Dietrich-Bonhoeffer-Klinikum, Neubrandenburg, Germany.

Jennifer Schulz (J)

Institute of Anatomy, Rostock University Medical Center, Rostock, Germany.

Oliver Schmitt (O)

Institute of Anatomy, Rostock University Medical Center, Rostock, Germany.
Department of Anatomy, Medical School Hamburg, University of Applied Sciences and Medical University, Hamburg, Germany.

Carsten Holzmann (C)

Institute of Medical Genetics, Rostock University Medical Center, Rostock, Germany.
Centre of Transdisciplinary Neuroscience Rostock, Rostock, Germany.

Arndt Rolfs (A)

Medical Faculty, University of Rostock, Rostock, Germany.

Hans-Jürgen Bidmon (HJ)

Institute of Neurosciences and Medicine, Structural and Functional Organisation of the Brain (INM-1), Forschungszentrum Jülich, Jülich, Germany.
Central Institute of Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.

Estibaliz González de San Román Martín (E)

Central Institute of Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.
Centro Joxe Mari Korta, Donostia, Spain.

Pitter F Huesgen (PF)

Central Institute of Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany.
Institut für Biologie II, AG Funktional Proteomics, Freiburg, Germany.

Katrin Amunts (K)

Institute of Neurosciences and Medicine, Structural and Functional Organisation of the Brain (INM-1), Forschungszentrum Jülich, Jülich, Germany.
C. and O. Vogt Institute for Brain Research, University Hospital Düsseldorf, University Düsseldorf, Düsseldorf, Germany.

Jonas Keiler (J)

Institute of Anatomy, Rostock University Medical Center, Rostock, Germany.

Niels Hammer (N)

Division of Macroscopic and Clinical Anatomy, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Department of Orthopedic and Trauma Surgery, University of Leipzig, Leipzig, Germany.
Division of Biomechatronics, Fraunhofer Institute for Machine Tools and Forming Technology, Dresden, Germany.

Martin Witt (M)

Institute of Anatomy, Rostock University Medical Center, Rostock, Germany.
Department of Anatomy, Technische Universität Dresden, Dresden, Germany.
Department of Anatomy, Institute of Biostructural Basics of Medical Sciences, Poznan Medical University, Poznan, Poland.

Andreas Wree (A)

Institute of Anatomy, Rostock University Medical Center, Rostock, Germany.
Centre of Transdisciplinary Neuroscience Rostock, Rostock, Germany.

Classifications MeSH