From data to practice: brain meningioma treatment in elderly patients - a survey of the Italian Society of Neurosurgery (SINch®) and systematic review and meta-analysis.
Aging
Elderly
Meningioma
Morbidity
Mortality
Outcome
Radiosurgery
Surgery
Journal
Neurosurgical review
ISSN: 1437-2320
Titre abrégé: Neurosurg Rev
Pays: Germany
ID NLM: 7908181
Informations de publication
Date de publication:
31 Jul 2024
31 Jul 2024
Historique:
received:
21
02
2024
accepted:
17
06
2024
revised:
02
05
2024
medline:
31
7
2024
pubmed:
31
7
2024
entrez:
31
7
2024
Statut:
epublish
Résumé
The management of meningioma in elderly patients (MEP) presents a complex and evolving challenge. Data available offer conflicting information on treatment options and complications. This survey aimed to examine the current approach to MEP, comparing the national profile to data in the current literature. A survey addressing the treatments options and management of meningioma in elderly was designed on behalf of SINch® (Società Italiana di Neurochirurgia) and sent via email to all Chiefs of Neurosurgical Departments. The survey remained open for responses from May 5th, 2022, until November 21st, 2022. A search of the literature published between January 2000 and March 2023, in accordance to PRISMA guidelines, was included. A total of 51 Neurosurgical centers participated in the survey. The caseload profile of each center influences the choice of treatment selection (Stereotactic Radiosurgery versus open surgery) (p = 0.01) and the consolidated practice of discussing cases within a multidisciplinary group (p = 0.02). The pooled meta-analysis demonstrated a significant increased risk in the elderly group for permanent deficits (p < 0.00001), postoperative infections (p = 0.0004) and hemorrhage (p = 0.0001), perioperative mortality (p < 0.00001), and medical complications (p < 0.00001) as compared to the young population. This study presents the initial comprehensive analysis of the existing trends in the surgical management of MEP in Italy. The significant variation in practices primarily stems from the absence of standardized guidelines. While most centers have adopted an integrated approach, there is a need to promote a multidisciplinary care model. Prospective studies are needed to gather robust evidence in this clinical setting.
Identifiants
pubmed: 39083092
doi: 10.1007/s10143-024-02524-8
pii: 10.1007/s10143-024-02524-8
doi:
Types de publication
Journal Article
Systematic Review
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
373Investigateurs
Giuseppe Barbagallo
(G)
Andrea Barbanera
(A)
Giacomo Beggio
(G)
Silvio Domenico Bellocchi
(SD)
Claudio Bernucci
(C)
Manuela Anna Caroli
(MA)
Marco Cenzato
(M)
Alessandro Della Puppa
(A)
Andrea Di Cristofori
(A)
Riccardo Draghi
(R)
Antonio Fioravanti
(A)
Marco Maria Fontanella
(MM)
Alessandro Frati
(A)
Filippo Gagliardi
(F)
Diego Garbossa
(D)
Antonino Germanò
(A)
Maurizio Iacoangeli
(M)
Luigi Antonio Lattanzi
(LA)
Federico Legnani
(F)
Davide Locatelli
(D)
Vincenza Maiola
(V)
Nicola Montemurro
(N)
Giovanni Muscas
(G)
Antonio Nicolato
(A)
Sergio Paolini
(S)
Giacomo Pavesi
(G)
Maurizio Piparo
(M)
Domenico Policicchio
(D)
Angelo Pompucci
(A)
Antonino Raco
(A)
Marta Rossetto
(M)
Giovanni Sabatino
(G)
Antonio Santoro
(A)
Silvio Sarubbo
(S)
Alba Scerrati
(A)
Francesco Signorelli
(F)
Fabio Spanu
(F)
Giannantonio Spena
(G)
Roberto Stefini
(R)
Stefano Telera
(S)
Luigino Tosatto
(L)
Roberto Trignani
(R)
Silvana Tumbiolo
(S)
Francesco Volpin
(F)
Giampaolo Zambon
(G)
Donato Carlo Zotta
(DC)
Informations de copyright
© 2024. The Author(s).
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