Interpretation of results of PCR and B-D-glucan for the diagnosis of Pneumocystis Jirovecii Pneumonia in immunocompromised adults with acute respiratory failure.

Pneumocystis pneumonia; sensitivity Beta-D glucan PCR Post test probability Specificity

Journal

Annals of intensive care
ISSN: 2110-5820
Titre abrégé: Ann Intensive Care
Pays: Germany
ID NLM: 101562873

Informations de publication

Date de publication:
31 Jul 2024
Historique:
received: 23 01 2024
accepted: 18 06 2024
medline: 31 7 2024
pubmed: 31 7 2024
entrez: 31 7 2024
Statut: epublish

Résumé

The accuracy of a diagnostic test depends on its intrinsic characteristics and the disease incidence. This study aims to depict post-test probability of Pneumocystis pneumonia (PJP), according to results of PCR and Beta-D-Glucan (BDG) tests in patients with acute respiratory failure (ARF). Diagnostic performance of PCR and BDG was extracted from literature. Incidence of Pneumocystis pneumonia was assessed in a dataset of 2243 non-HIV immunocompromised patients with ARF. Incidence of Pneumocystis pneumonia was simulated assuming a normal distribution in 5000 random incidence samples. Post-test probability was assessed using Bayes theorem. Incidence of PJP in non-HIV ARF patients was 4.1% (95%CI 3.3-5). Supervised classification identified 4 subgroups of interest with incidence ranging from 2.0% (No ground glass opacities; 95%CI 1.4-2.8) to 20.2% (hematopoietic cell transplantation, ground glass opacities and no PJP prophylaxis; 95%CI 14.1-27.7). In the overall population, positive post-test probability was 32.9% (95%CI 31.1-34.8) and 22.8% (95%CI 21.5-24.3) for PCR and BDG, respectively. Negative post-test probability of being infected was 0.10% (95%CI 0.09-0.11) and 0.23% (95%CI 0.21-0.25) for PCR and BDG, respectively. In the highest risk subgroup, positive predictive value was 74.5% (95%CI 72.0-76.7) and 63.8% (95%CI 60.8-65.8) for PCR and BDG, respectively. Although both tests yield a high intrinsic performance, the low incidence of PJP in this cohort resulted in a low positive post-test probability. We propose a method to illustrate pre and post-test probability relationship that may improve clinician perception of diagnostic test performance according to disease incidence in predefined clinical settings.

Sections du résumé

BACKGROUND BACKGROUND
The accuracy of a diagnostic test depends on its intrinsic characteristics and the disease incidence. This study aims to depict post-test probability of Pneumocystis pneumonia (PJP), according to results of PCR and Beta-D-Glucan (BDG) tests in patients with acute respiratory failure (ARF).
MATERIALS AND METHODS METHODS
Diagnostic performance of PCR and BDG was extracted from literature. Incidence of Pneumocystis pneumonia was assessed in a dataset of 2243 non-HIV immunocompromised patients with ARF. Incidence of Pneumocystis pneumonia was simulated assuming a normal distribution in 5000 random incidence samples. Post-test probability was assessed using Bayes theorem.
RESULTS RESULTS
Incidence of PJP in non-HIV ARF patients was 4.1% (95%CI 3.3-5). Supervised classification identified 4 subgroups of interest with incidence ranging from 2.0% (No ground glass opacities; 95%CI 1.4-2.8) to 20.2% (hematopoietic cell transplantation, ground glass opacities and no PJP prophylaxis; 95%CI 14.1-27.7). In the overall population, positive post-test probability was 32.9% (95%CI 31.1-34.8) and 22.8% (95%CI 21.5-24.3) for PCR and BDG, respectively. Negative post-test probability of being infected was 0.10% (95%CI 0.09-0.11) and 0.23% (95%CI 0.21-0.25) for PCR and BDG, respectively. In the highest risk subgroup, positive predictive value was 74.5% (95%CI 72.0-76.7) and 63.8% (95%CI 60.8-65.8) for PCR and BDG, respectively.
CONCLUSION CONCLUSIONS
Although both tests yield a high intrinsic performance, the low incidence of PJP in this cohort resulted in a low positive post-test probability. We propose a method to illustrate pre and post-test probability relationship that may improve clinician perception of diagnostic test performance according to disease incidence in predefined clinical settings.

Identifiants

pubmed: 39083132
doi: 10.1186/s13613-024-01337-8
pii: 10.1186/s13613-024-01337-8
doi:

Types de publication

Journal Article

Langues

eng

Pagination

120

Subventions

Organisme : Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation
ID : PHRC AOM 08235

Informations de copyright

© 2024. The Author(s).

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Auteurs

Laure Calvet (L)

Medical ICU, Saint-Louis University Hospital, AP-HP, 1 Avenue Claude Vellefaux, Paris, 75010, France.
Medical ICU, CHU Gabriel Montpied, Clermont-Ferrand, France.

Virginie Lemiale (V)

Medical ICU, Saint-Louis University Hospital, AP-HP, 1 Avenue Claude Vellefaux, Paris, 75010, France.

Djamel Mokart (D)

Department of anesthesiology and Intensive Care, Institut Paoli-Calmettes, Marseille, France.

Schellongowski Peter (S)

Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Pickkers Peter (P)

The Department of Intensive Care Medicine (710), Radboud University Medical Center, Nijmegen, The Netherlands.

Alexande Demoule (A)

Medical ICU and Pneumology, Pitié-Salpétrière University Hospital, APHP, Paris, France.

Sangeeta Mehta (S)

Department of Medicine, Interdepartmental Division of Critical Care Medicine, Sinai Health System, University of Toronto, Toronto, Canada.

Achille Kouatchet (A)

Intensive Care Unit, Angers University Hospital, Angers, France.

Jordi Rello (J)

Centro de Investigacion Biomedica en Red en Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Barcelona, Spain.
Clinical Research/Epidemiology In Pneumonia and Sepsis (CRIPS), Clinical Research, Vall d'Hebron Institute of Research (VHIR), CHU Nîmes, Barcelona, Nîmes, Spain.

Philippe Bauer (P)

Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.

Ignacio Martin-Loeches (I)

Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James Hospital, Dublin, Ireland.
Department of Clinical Medicine, Wellcome Trust‑HRB Clinical Research Facility, St. James's Hospital, Trinity College, Dublin, Ireland.
Hospital de Barcelona, IDIBAPS, CIBERes, Barcelona, Spain.

Amelie Seguin (A)

Medical ICU, Nantes University Hospital, Nantes, France.

Victoria Metaxa (V)

King's College Hospital, SE5 9RS, London, UK.

Magali Bisbal (M)

Department of anesthesiology and Intensive Care, Institut Paoli-Calmettes, Marseille, France.

Elie Azoulay (E)

Medical ICU, Saint-Louis University Hospital, AP-HP, 1 Avenue Claude Vellefaux, Paris, 75010, France.
ECSTRA team, Biostatistics and clinical epidemiology, Université de Paris, UMR 1153 (center of epidemiology and biostatistic Sorbonne Paris Cité, CRESS), INSERM, Paris, France.

Michael Darmon (M)

Medical ICU, Saint-Louis University Hospital, AP-HP, 1 Avenue Claude Vellefaux, Paris, 75010, France. michael.darmon@aphp.fr.
ECSTRA team, Biostatistics and clinical epidemiology, Université de Paris, UMR 1153 (center of epidemiology and biostatistic Sorbonne Paris Cité, CRESS), INSERM, Paris, France. michael.darmon@aphp.fr.

Classifications MeSH