Collapsing Glomerulopathy.

Humans Apolipoprotein L1 / genetics Podocytes / pathology Kidney Glomerulus / pathology Signal Transduction Apolipoproteins / genetics
APOL1 Collapsing glomerulopathy Focal segmental glomerulosclerosis Interferon Nephrotic syndrome Podocyte

Journal

Advances in kidney disease and health
ISSN: 2949-8139
Titre abrégé: Adv Kidney Dis Health
Pays: United States
ID NLM: 9918523075306676

Informations de publication

Date de publication:
Jul 2024
Historique:
received: 26 06 2023
revised: 08 03 2024
accepted: 25 03 2024
medline: 1 8 2024
pubmed: 1 8 2024
entrez: 31 7 2024
Statut: ppublish

Résumé

Collapsing glomerulopathy (CG) is a pattern of kidney injury characterized by segmental or global collapse of the glomerular tuft associated with overlying epithelial cell hyperplasia. Although CG may be idiopathic, a wide range of etiologies have been identified that can lead to this pattern of injury. Recent advances have highlighted the role of inflammatory and interferon signaling pathways and upregulation of apolipoprotein L1 (APOL1) within podocytes in those carrying a high-risk APOL1 genotype. In this review, we describe the etiology, pathogenesis, pathology, and clinical course of CG, focusing on nonviral etiologies. We also describe current treatments and explore potential therapeutic options targeting interferon/APOL1 pathways in CG.

Identifiants

DOI: 10.1053/j.akdh.2024.03.008 PMID: 39084754
pubmed: 39084754
pii: S2949-8139(24)00058-2
doi: 10.1053/j.akdh.2024.03.008
pii:
doi:

Substances chimiques

Apolipoprotein L1 0
APOL1 protein, human 0
Apolipoproteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

290-298

Informations de copyright

Copyright © 2024 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Auteurs

Abbal Koirala (A)

Division of Nephrology, University of Washington, Seattle, Washington.

Shreeram Akilesh (S)

Department of Pathology, University of Washington, Seattle, Washington.

J Ashley Jefferson (JA)

Division of Nephrology, University of Washington, Seattle, Washington. Electronic address: jashleyj@uw.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Collapsing Glomerulopathy.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines L › Apolipoprotéine L1 › Collapsing Glomerulopathy.
questionsmedicales.fr › Cellules › Cellules épithéliales › Podocytes › Collapsing Glomerulopathy.
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Glomérule rénal › Collapsing Glomerulopathy.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Collapsing Glomerulopathy.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Collapsing Glomerulopathy.