Therapy for Hyperlipidemia.

Humans Hyperlipidemias / drug therapy Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Hypolipidemic Agents / therapeutic use Ezetimibe / therapeutic use Anticholesteremic Agents / therapeutic use PCSK9 Inhibitors
ASCVD Bempedoic acid Coronary artery calcium Ezetimibe Hypertriglyceridemia Lipoprotein (a) PCSK9 inhibitors Statins

Journal

The Medical clinics of North America
ISSN: 1557-9859
Titre abrégé: Med Clin North Am
Pays: United States
ID NLM: 2985236R

Informations de publication

Date de publication:
Sep 2024
Historique:
medline: 1 8 2024
pubmed: 1 8 2024
entrez: 31 7 2024
Statut: ppublish

Résumé

Significant advances in atherosclerotic cardiovascular (ASCVD) risk stratification and treatment have occurred over the past 10 years. While the lipid panel continues to be the basis of risk estimation, imaging for coronary artery calcium is now widely used in estimating risk at the individual level. Statins remain first-line agents for ASCVD risk reduction but in high-risk patients, ezetimibe, proprotein convertase subtilisin kexin-9 inhibitors, and bempedoic acid can be added to further reduce individual cardiovascular risk based on results of cardiovascular outcomes trials. Results of randomized control trials do not support use of medications targeted at triglyceride lowering for ASCVD risk reduction, but icosapent ethyl can be considered.

Identifiants

DOI: 10.1016/j.mcna.2024.03.005 PMID: 39084839
pubmed: 39084839
pii: S0025-7125(24)00022-1
doi: 10.1016/j.mcna.2024.03.005
pii:
doi:

Substances chimiques

Hydroxymethylglutaryl-CoA Reductase Inhibitors 0
Hypolipidemic Agents 0
Ezetimibe EOR26LQQ24
Anticholesteremic Agents 0
PCSK9 Inhibitors 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

881-894

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Auteurs

Jennifer Wright (J)

Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: sonic@uw.edu.

Savitha Subramanian (S)

Division of Metabolism, Endocrinology and Nutrition, University of Washington, RR-512 Health Sciences Building, Box 356420, 1959 NE Pacific Street, Seattle, WA 98195-6420, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Therapy for Hyperlipidemia.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme lipidique › Dyslipidémies › Hyperlipidémies › Therapy for Hyperlipidemia.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs du métabolisme des lipides › Hypolipémiants › Anticholestérolémiants › Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase › Therapy for Hyperlipidemia.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs du métabolisme des lipides › Hypolipémiants › Therapy for Hyperlipidemia.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azétines › Azétidines › Ézétimibe › Therapy for Hyperlipidemia.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs du métabolisme des lipides › Hypolipémiants › Anticholestérolémiants › Therapy for Hyperlipidemia.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs du métabolisme des lipides › Hypolipémiants › Anticholestérolémiants › Inhibiteurs de PCSK9 › Therapy for Hyperlipidemia.