[A Case Report of Successful Treatment with Dose-controlled mFOFOX6+Bevacizumab for Metastatic Colorectal Cancer in Patient Receiving Hemodialysis].


Journal

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
ISSN: 1347-5231
Titre abrégé: Yakugaku Zasshi
Pays: Japan
ID NLM: 0413613

Informations de publication

Date de publication:
2024
Historique:
medline: 1 8 2024
pubmed: 1 8 2024
entrez: 31 7 2024
Statut: ppublish

Résumé

A 65-years-old man undergoing hemodialysis for chronic kidney disease was diagnosed with ascending colon cancer and 3 hepatic metastases. He was administered mFOLFOX6 (reducing the dose to 50%) plus bevacizumab (BEV) therapy. Hemodialysis was performed 4 h after administration of oxaliplatin on day1 and repeated three times a week. No serious adverse events were observed. After 4 courses of chemotherapy, a computer tomography scan showed that the hepatic metastases had reduced. 2 courses of mFOLFOX6 (increasing the dose to 75%) plus BEV therapy were added, he was operated by laparoscopic right hemicolectomy and laparoscopic patrial hepatectomy. He has been in remission for 2 years and 4 months since the surgery. Dose-adjusted chemotherapy with hemodialysis was effective and improve the prognosis of the patient.

Identifiants

pubmed: 39085061
doi: 10.1248/yakushi.24-00004
doi:

Substances chimiques

Bevacizumab 2S9ZZM9Q9V
Organoplatinum Compounds 0
Fluorouracil U3P01618RT
Leucovorin Q573I9DVLP

Types de publication

Case Reports Journal Article English Abstract

Langues

jpn

Sous-ensembles de citation

IM

Pagination

847-852

Auteurs

Ayumi Ozeki (A)

Shonan University of Medical Sciences.
Department of Pharmacy, Shonan General Hospital.

Hideya Kokubun (H)

Shonan University of Medical Sciences.

Sho Ibuki (S)

Department of Surgery, Shonan General Hospital.

Masayuki Inamoto (M)

Department of Pharmacy, Shonan General Hospital.

Yoshihiko Sakurai (Y)

Department of Surgery, Shonan General Hospital.

Takahiro Otani (T)

Department of Pharmacy, Shonan General Hospital.

Junya Sato (J)

Shonan University of Medical Sciences.

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Classifications MeSH