Does BioAge identify accelerated aging in individuals with bipolar disorder? An exploratory study in the FACE-BD cohort.
accelerated aging
bioage
biological age
bipolar disorder
determinants
medications
obesity
sleep
Journal
Bipolar disorders
ISSN: 1399-5618
Titre abrégé: Bipolar Disord
Pays: Denmark
ID NLM: 100883596
Informations de publication
Date de publication:
31 Jul 2024
31 Jul 2024
Historique:
medline:
1
8
2024
pubmed:
1
8
2024
entrez:
31
7
2024
Statut:
aheadofprint
Résumé
Individuals with bipolar disorders (BD) have an estimated loss of life expectancy around 10-15 years. Several laboratory-measured biomarkers of accelerated aging exist (e.g., telomere length), however with a questionable transferability to bedside. There is a need for easily and inexpensively measurable markers of aging, usable in routine practice, such as BioAge. We calculated BioAge that estimates biological age based on routine blood tests and a physical exam, in a sample of 2220 outpatients with BD. We investigated associations between BioAge Acceleration (BioAgeAccel), which is an indicator of accelerated aging, and sociodemographic variables, clinical variables, and current psychotropic medication use. Mean chronological age was 40.2 (±12.9). Mean BioAge was 39.1 (±12.4). Mean BioAgeAccel was 0.08 (±1.8). A minority of individuals (15%) had a BioAgeAccel above 2 years. Multivariable analyses suggested strong associations between a higher BioAgeAccel and younger age, male sex, overweight and sleep disturbances. Regarding current psychotropic medication use, discrepancies between univariate and multivariate analyses were observed. A minority of individuals with BD had an accelerated aging as measured by BioAge. We identified associations with potentially modifiable factors, such as higher body mass index and sleep disturbances, that are however nonspecific to BD. These results require replications in independent samples of individuals with BD, and comparisons with a control group matched for age and gender. Longitudinal studies are also required to test whether any change in metabolic health, or sleep might decrease BioAgeAccel.
Sections du résumé
BACKGROUND
BACKGROUND
Individuals with bipolar disorders (BD) have an estimated loss of life expectancy around 10-15 years. Several laboratory-measured biomarkers of accelerated aging exist (e.g., telomere length), however with a questionable transferability to bedside. There is a need for easily and inexpensively measurable markers of aging, usable in routine practice, such as BioAge.
METHODS
METHODS
We calculated BioAge that estimates biological age based on routine blood tests and a physical exam, in a sample of 2220 outpatients with BD. We investigated associations between BioAge Acceleration (BioAgeAccel), which is an indicator of accelerated aging, and sociodemographic variables, clinical variables, and current psychotropic medication use.
RESULTS
RESULTS
Mean chronological age was 40.2 (±12.9). Mean BioAge was 39.1 (±12.4). Mean BioAgeAccel was 0.08 (±1.8). A minority of individuals (15%) had a BioAgeAccel above 2 years. Multivariable analyses suggested strong associations between a higher BioAgeAccel and younger age, male sex, overweight and sleep disturbances. Regarding current psychotropic medication use, discrepancies between univariate and multivariate analyses were observed.
CONCLUSIONS
CONCLUSIONS
A minority of individuals with BD had an accelerated aging as measured by BioAge. We identified associations with potentially modifiable factors, such as higher body mass index and sleep disturbances, that are however nonspecific to BD. These results require replications in independent samples of individuals with BD, and comparisons with a control group matched for age and gender. Longitudinal studies are also required to test whether any change in metabolic health, or sleep might decrease BioAgeAccel.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
B Etain
(B)
E Olié
(E)
M Leboyer
(M)
E Haffen
(E)
P M Llorca
(PM)
V Barteau
(V)
S Bensalem
(S)
O Godin
(O)
H Laouamri
(H)
K Souryis
(K)
S Hotier
(S)
A Pelletier
(A)
L Wuillaume
(L)
E Bourdin
(E)
F Bellivier
(F)
B Etain
(B)
V Hennion
(V)
E Marlinge
(E)
P Lebard
(P)
B Aouizerate
(B)
A Desage
(A)
S Gard
(S)
A Jutant
(A)
K Mbailara
(K)
I Minois
(I)
L Zanouy
(L)
C Abettan
(C)
L Bardin
(L)
A Cazals
(A)
P Courtet
(P)
B Deffinis
(B)
D Ducasse
(D)
M Gachet
(M)
A Henrion
(A)
E Martinerie
(E)
F Molière
(F)
B Noisette
(B)
E Olié
(E)
G Tarquini
(G)
M Cermolacce
(M)
N Correard
(N)
J L Consoloni
(JL)
F Groppi
(F)
L Lescalier
(L)
J Montant
(J)
M Rebattu
(M)
N Viglianese
(N)
R Cohen
(R)
G Gross
(G)
R Schwan
(R)
T Schwitzer
(T)
O Wajsbrot-Elgrabli
(O)
T Bougerol
(T)
B Fredembach
(B)
Q Denoual
(Q)
A Bertrand
(A)
A Pouchon
(A)
M Polosan
(M)
G Bonny
(G)
L Brehon
(L)
L Durand
(L)
V Feuga
(V)
A M Galliot
(AM)
N Kayser
(N)
C Passerieux
(C)
P Roux
(P)
V Aubin
(V)
I Cussac
(I)
M A Dupont
(MA)
J Loftus
(J)
I Medecin
(I)
C Dubertret
(C)
N Mazer
(N)
C Portalier
(C)
C Dubertret
(C)
Pauline Laurent
(P)
C Beal
(C)
O Blanc
(O)
T Bonnet
(T)
D Lacelle
(D)
P M Llorca
(PM)
M Mennetrier
(M)
L Samalin
(L)
M Vayssié
(M)
Informations de copyright
© 2024 The Author(s). Bipolar Disorders published by John Wiley & Sons Ltd.
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