Age-related alveolar bone maladaptation in adult orthodontics: finding new ways out.
Journal
International journal of oral science
ISSN: 2049-3169
Titre abrégé: Int J Oral Sci
Pays: India
ID NLM: 101504351
Informations de publication
Date de publication:
01 Aug 2024
01 Aug 2024
Historique:
received:
09
02
2024
accepted:
18
06
2024
revised:
16
06
2024
medline:
1
8
2024
pubmed:
1
8
2024
entrez:
31
7
2024
Statut:
epublish
Résumé
Compared with teenage patients, adult patients generally show a slower rate of tooth movement and more pronounced alveolar bone loss during orthodontic treatment, indicating the maladaptation of alveolar bone homeostasis under orthodontic force. However, this phenomenon is not well-elucidated to date, leading to increased treatment difficulties and unsatisfactory treatment outcomes in adult orthodontics. Aiming to provide a comprehensive knowledge and further inspire insightful understanding towards this issue, this review summarizes the current evidence and underlying mechanisms. The age-related abatements in mechanosensing and mechanotransduction in adult cells and periodontal tissue may contribute to retarded and unbalanced bone metabolism, thus hindering alveolar bone reconstruction during orthodontic treatment. To this end, periodontal surgery, physical and chemical cues are being developed to reactivate or rejuvenate the aging periodontium and restore the dynamic equilibrium of orthodontic-mediated alveolar bone metabolism. We anticipate that this review will present a general overview of the role that aging plays in orthodontic alveolar bone metabolism and shed new light on the prospective ways out of the impasse.
Identifiants
pubmed: 39085217
doi: 10.1038/s41368-024-00319-7
pii: 10.1038/s41368-024-00319-7
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
52Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 51972005
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82201017
Organisme : China Postdoctoral Science Foundation
ID : 2022M710257
Informations de copyright
© 2024. The Author(s).
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