Missed Follow-up is associated with worse survival in stage I lung cancer: results from a large multi-site academic hospital system.
Follow up
Lung cancer
Surveillance
Survival
Survivorship
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
31 Jul 2024
31 Jul 2024
Historique:
received:
11
12
2023
accepted:
23
07
2024
medline:
1
8
2024
pubmed:
1
8
2024
entrez:
31
7
2024
Statut:
epublish
Résumé
The purpose of this study is to examine the effect of early incomplete follow-up on overall survival among stage I lung cancer patients. Patients with clinical stage I lung cancer at our institution between 2007 and 2016 were identified (N = 1111). Exclusions included < 18 years of age (N = 2), missing stage or demographics (N = 56), incomplete appointment data or had only one scheduled appointment (N = 351), or did not survive for at least 1 year after diagnosis (N = 120). Missed appointments were defined as unattended follow-up appointments within the first year of diagnosis without an attended appointment in the subsequent 60 days. The primary outcome was the hazard ratio (HR) for death associated per 10% increase in missed oncology follow-up appointments. Univariable and descriptive statistics were performed, and a multivariable landmark Cox regression model was created to examine the effect of missed oncology follow-up on survival. A total of 582 patients were analyzed with median follow-up of 3.2 years and median age of 69 years. On multivariable analysis controlling for age, sex, race, insurance status, and definitive treatment type the HR for death was 1.44 (95% CI 1.05-1.97) for every 10% increase in missed appointments. Incomplete oncologic follow-up may negatively impact overall survival among survivors of early-stage lung cancer.
Identifiants
pubmed: 39085317
doi: 10.1038/s41598-024-68351-5
pii: 10.1038/s41598-024-68351-5
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
17710Subventions
Organisme : NIH HHS
ID : UL1TR002529 (A. Shekhar, PI)
Pays : United States
Informations de copyright
© 2024. The Author(s).
Références
Siegel, R. L., Miller, K. D., Fuchs, H. E. & Jemal, A. Cancer statistics, 2022. CA Cancer J. Clin. 72(1), 7–33. https://doi.org/10.3322/caac.21708 (2022).
doi: 10.3322/caac.21708
pubmed: 35020204
The National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. N. Engl. J. Med. 365(5), 395–408. https://doi.org/10.1056/NEJMoa1102873 (2011).
doi: 10.1056/NEJMoa1102873
pmcid: 4356534
National Comprehensive Cancer Network. Small Cell Lung Cancer NCCN Evidence Blocks. Accessed March 10, 2019. https://www.nccn.org/professionals/physician_gls/pdf/sclc_blocks.pdf (2018).
National Comprehensive Cancer Network. Non-Small Cell Lung Cancer NCCN Evidence Blocks. Accessed March 10, 2019. https://www.nccn.org/professionals/physician_gls/pdf/nscl_blocks.pdf (2019).
Carr, S. R. et al. Impact of tumor size on outcomes after anatomic lung resection for stage 1A non-small cell lung cancer based on the current staging system. J. Thorac. Cardiovasc. Surg. 143, 390–397. https://doi.org/10.1016/j.jtcvs.2011.10.023 (2012).
doi: 10.1016/j.jtcvs.2011.10.023
pubmed: 22169444
Saynak, M. et al. Local failure after complete resection of N0–1 non-small cell lung cancer. Lung Cancer 71, 156–165. https://doi.org/10.1016/j.lungcan.2010.06.001 (2011).
doi: 10.1016/j.lungcan.2010.06.001
pubmed: 20615576
CDC. 2013 NCHS Urban-Rural Classification Scheme for Counties. Vital and Health Statistics, Series 2, Number 166 (2014).
Mugavero, M. J. et al. Missed visits and mortality in patients establishing initial outpatient HIV treatment. Clin. Infect. Dis. 48(2), 248–256. https://doi.org/10.1086/595705 (2009).
doi: 10.1086/595705
pubmed: 19072715
Gardner, L. I. et al. Efficacy of a brief case management intervention to link recently diagnosed HIV-infected persons to care. Aids 19(4), 423–431. https://doi.org/10.1097/01.aids.0000161772.51900.eb (2005).
doi: 10.1097/01.aids.0000161772.51900.eb
pubmed: 15750396
Jones, W. B. et al. Lost to follow-up: A potential under-appreciated limitation of endovascular aneurysm repair. J. Vasc. Surg. 46(3), 434–440. https://doi.org/10.1016/j.jvs.2007.05.002 (2007).
doi: 10.1016/j.jvs.2007.05.002
pubmed: 17826228
McQueenie, R., Ellis, D. A., McConnachie, A., Wilson, P. & Williamson, A. E. Morbidity, mortality and missed appointments in healthcare: A national retrospective data linkage study. BMC Med. 17(1), 2. https://doi.org/10.1186/s12916-018-1234-0 (2019).
doi: 10.1186/s12916-018-1234-0
pubmed: 30630493
pmcid: 6329132
Cronin, P. R., DeCoste, L. & Kimball, A. B. A multivariate analysis of dermatology missed appointment predictors. JAMA Dermatol. 149(12), 1435–1437. https://doi.org/10.1001/jamadermatol.2013.5771 (2013).
doi: 10.1001/jamadermatol.2013.5771
pubmed: 24080767
Kaplan-Lewis, E. & Percac-Lima, S. No-show to primary care appointments: Why patients do not come. J. Prim. Care Community Health 4(4), 251–254. https://doi.org/10.1177/2150131913498513 (2013).
doi: 10.1177/2150131913498513
pubmed: 24327664
Meng, W. et al. MicroRNA-31 predicts the presence of lymph node metastases and survival in lung adenocarcinoma patients. Clin. Cancer Res. 19(19), 5423–5432. https://doi.org/10.1158/1078-0432.CCR-13-0320 (2013).
doi: 10.1158/1078-0432.CCR-13-0320
pubmed: 23946296
Siddika, A., Tolia-Shah, D., Pearson, T. E., Richardson, N. G. B. & Ross, A. H. Remote surveillance after colorectal cancer surgery: An effective alternative to standard clinic-based follow-up. Colorectal Dis. 17(10), 870–875. https://doi.org/10.1111/codi.12970 (2015).
doi: 10.1111/codi.12970
pubmed: 25851058