Cranioencephalic functional lymphoid units in glioblastoma.
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
31 Jul 2024
31 Jul 2024
Historique:
received:
26
06
2023
accepted:
25
06
2024
medline:
1
8
2024
pubmed:
1
8
2024
entrez:
31
7
2024
Statut:
aheadofprint
Résumé
The ecosystem of brain tumors is considered immunosuppressed, but our current knowledge may be incomplete. Here we analyzed clinical cell and tissue specimens derived from patients presenting with glioblastoma or nonmalignant intracranial disease to report that the cranial bone (CB) marrow, in juxtaposition to treatment-naive glioblastoma tumors, harbors active lymphoid populations at the time of initial diagnosis. Clinical and anatomical imaging, single-cell molecular and immune cell profiling and quantification of tumor reactivity identified CD8
Identifiants
pubmed: 39085419
doi: 10.1038/s41591-024-03152-x
pii: 10.1038/s41591-024-03152-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wilhelm Sander-Stiftung (Wilhelm Sander Foundation)
ID : 2019.008.2
Organisme : Wilhelm Sander-Stiftung (Wilhelm Sander Foundation)
ID : 2019.008.2
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : SCHE656/2-2, proj#405344257
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : HE 8145/6-1/5-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : RE 2246/13-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : SFB1399-A01
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : SFB1430-A09
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : SFB1530-A01
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 404521405; SFB1389-UNITE
Organisme : Deutsche Krebshilfe (German Cancer Aid)
ID : 1117240, 70113041
Informations de copyright
© 2024. The Author(s).
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