Bardet-Biedl syndrome improved diagnosis criteria and management: Inter European Reference Networks consensus statement and recommendations.


Journal

European journal of human genetics : EJHG
ISSN: 1476-5438
Titre abrégé: Eur J Hum Genet
Pays: England
ID NLM: 9302235

Informations de publication

Date de publication:
31 Jul 2024
Historique:
received: 13 12 2023
accepted: 09 05 2024
revised: 15 03 2024
medline: 1 8 2024
pubmed: 1 8 2024
entrez: 31 7 2024
Statut: aheadofprint

Résumé

Four European Reference Networks (ERN-EYE, ERKNet, Endo-ERN, ERN-ITHACA) have teamed up to establish a consensus statement and recommendations for Bardet-Biedl syndrome (BBS). BBS is an autosomal recessive ciliopathy with at least 26 genes identified to date. The clinical manifestations are pleiotropic, can be observed in utero and will progress with age. Genetic testing has progressively improved in the last years prompting for a revision of the diagnostic criteria taking into account clinical Primary and Secondary features, as well as positive or negative molecular diagnosis. This consensus statement also emphasizes on initial diagnosis, monitoring and lifelong follow-up, and symptomatic care that can be provided to patients and family members according to the involved care professionals. For paediatricians, developmental anomalies can be at the forefront for diagnosis (such as polydactyly) but can require specific care, such as for associated neuro developmental disorders. For ophthalmology, the early onset retinal degeneration requires ad hoc functional and imaging technologies and specific care for severe visual impairment. For endocrinology, among other manifestations, early onset obesity and its complications has benefited from better evaluation of eating behaviour problems, improved lifestyle programs, and from novel pharmacological therapies. Kidney and urinary track involvements warrants lifespan attention, as chronic kidney failure can occur and early management might improve outcome. This consensus recommends revised diagnostic criteria for BBS that will ensure certainty of diagnosis, giving robust grounds for genetic counselling as well as in the perspective of future trials for innovative therapies.

Identifiants

pubmed: 39085583
doi: 10.1038/s41431-024-01634-7
pii: 10.1038/s41431-024-01634-7
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Hélène Dollfus (H)

ERN-EYE Centre de Référence Pour les Affections Rares en Génétique Ophtalmologique (CRMR CARGO), Institut de Génétique Médicale d'Alsace (IGMA), FSMR SENSGENE, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. dollfus@unistra.fr.
Université de Strasbourg, UMRS_1112, Strasbourg, France. dollfus@unistra.fr.

Marc R Lilien (MR)

ERKNet Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands.

Pietro Maffei (P)

Endo-ERN Department of Medicine (DIMED), 3rd Medical Clinic, Padua University, Padua, Italy.

Alain Verloes (A)

ERN-ITHACA Department of Genetics, AP-HP - Université de Paris; INSERM UMR 1141 "NeuroDiderot", Hôpital Robert Debré, Paris, France.

Jean Muller (J)

Laboratoires de Diagnostic Génétique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Unité Fonctionnelle de Bioinformatique Médicale Appliquée au Diagnostic (UF7363), Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, UMRS_1112, Strasbourg, France.

Giacomo M Bacci (GM)

ERN-EYE Pediatric Ophthalmology Unit, Meyer Children's Hospital IRCCS, University of Florence, Florence, Italy.

Metin Cetiner (M)

ERKNet Children's Hospital, Pediatrics II, University of Essen, Essen, Germany.

Erica L T van den Akker (ELT)

Endo-ERN Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam, Division of Endocrinology, Department of Pediatrics, Erasmus MC-Sophia, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Monika Grudzinska Pechhacker (M)

ERN-EYE Coordination Center, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Francesco Testa (F)

ERN-EYE Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

Didier Lacombe (D)

ERN-ITHACA Department of Medical Genetics, CHU Bordeaux, INSERM Unit_1211, Laboratory "Rare Diseases: Genetics and Metabolism", University of Bordeaux, Bordeaux, France.

Marijn F Stokman (MF)

ERKNet Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands.

Francesca Simonelli (F)

ERN-EYE Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

Aurélie Gouronc (A)

ERN-EYE Centre de Référence Pour les Affections Rares en Génétique Ophtalmologique (CRMR CARGO), Institut de Génétique Médicale d'Alsace (IGMA), FSMR SENSGENE, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Université de Strasbourg, UMRS_1112, Strasbourg, France.
Laboratoires de Diagnostic Génétique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Unité Fonctionnelle de Bioinformatique Médicale Appliquée au Diagnostic (UF7363), Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, UMRS_1112, Strasbourg, France.

Amélie Gavard (A)

ERN-EYE Coordination Center, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Mieke M van Haelst (MM)

ERN-ITHACA Department of Human Genetics, Section Clinical Genetics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.

Jens Koenig (J)

ERKNet University Children's Hospital Muenster, Muenster, NRW, Germany.

Sylvie Rossignol (S)

Endo-ERN Département de Pédiatrie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Carsten Bergmann (C)

Department of Medicine IV, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.
Medizinische Genetik Mainz, Limbach Genetics, Mainz, Germany.

Miriam Zacchia (M)

ERKNet Division of Nephrology, Department of Translational Medical Sciences, University of Campania "L. Vanvitelli", Naples, Italy.

Bart P Leroy (BP)

ERN-EYE Department of Ophthalmology & Department of Head & Skin, Ghent University Hospital and Ghent University, Ghent, Belgium.
Center for Cellular and Molecular Therapeutics and Division of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Héléna Mosbah (H)

Endo-ERN Department of Endocrinology, Diabetology & Nutrition, University Hospital of Poitiers, Poitiers, France.

Albertien M Van Eerde (AM)

ERKNet Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.

Djalila Mekahli (D)

ERKNet PKD Research Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Department of Pediatric Nephrology, University Hospitals Leuven, Leuven, Belgium.

Aude Servais (A)

ERKNet Department of Kidney and Metabolic Diseases, Transplantation and Clinical Immunology, Necker Hospital, AP-HP, Centre of Reference for the French Nationwide MARHEANetwork (CNR-MARHEA), Paris, France.
Inserm U1163, Imagine Institute, Paris, France.

Christine Poitou (C)

Endo-ERN Centre de Référence pour les obésités rares (CRMR PRADORT), Assistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Sorbonne Université, INSERM, Nutrition & Obesities: Systemic Approaches Research Group (NutriOmics), Paris, France.

Diana Valverde (D)

CINBIO, Universidad de Vigo, Grupo de Investigación en Enfermedades Raras, Instituto de Investigación Sanitaria Galicia Sur (IIS Galicia Sur), Vigo, Spain.

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