How strong is the evidence supporting the WHO guidelines on physical activity, sedentary behaviour and sleep in early childhood?

WHO guidelines early childhood physical activity screen time sedentary behaviour sleep

Journal

European journal of clinical investigation
ISSN: 1365-2362
Titre abrégé: Eur J Clin Invest
Pays: England
ID NLM: 0245331

Informations de publication

Date de publication:
31 Jul 2024
Historique:
received: 03 06 2024
accepted: 20 07 2024
medline: 1 8 2024
pubmed: 1 8 2024
entrez: 1 8 2024
Statut: aheadofprint

Résumé

The WHO issued recommendations about the ideal amount of physical activity, sedentary behaviour and sleep in infants, toddlers and preschool children. To facilitate their interpretation and translation into public health policies, we analysed the quantity and quality of the evidence that supported the development of each WHO recommendation. All data for each exposure-outcome pair analysed in the studies informing WHO guidelines were extracted, and predefined criteria, based upon GRADE methodology, were used to classify each outcome and study result. Among the 237 studies that could be included, 37 were experimental and 200 were observational, yielding 920 analyses of exposure-outcome associations. Sixty-two analyses used a relevant outcome, with or without significant results. Five of the 10 WHO recommendations were based upon zero analyses with significant results on relevant health outcomes. The remaining recommendations were mostly based upon analyses evaluating obesity-related outcomes. Eight of the 10 GLs thresholds were not supported by any significant analysis on clinically relevant outcomes. While these findings should not be interpreted as an attempt to disprove the benefits of healthy lifestyle habits in early childhood, neither to minimize the work of the experts in this complex research field, very limited evidence currently supports the adoption of recommended thresholds as behavioural surveillance and public health interventions targets. Therefore, until further data are available, public health interventions should be developed balancing whether to focus on the achievement of specific targets that are still not supported by high-quality evidence or on the general promotion of healthy behaviours.

Sections du résumé

BACKGROUND BACKGROUND
The WHO issued recommendations about the ideal amount of physical activity, sedentary behaviour and sleep in infants, toddlers and preschool children. To facilitate their interpretation and translation into public health policies, we analysed the quantity and quality of the evidence that supported the development of each WHO recommendation.
METHODS METHODS
All data for each exposure-outcome pair analysed in the studies informing WHO guidelines were extracted, and predefined criteria, based upon GRADE methodology, were used to classify each outcome and study result.
RESULTS RESULTS
Among the 237 studies that could be included, 37 were experimental and 200 were observational, yielding 920 analyses of exposure-outcome associations. Sixty-two analyses used a relevant outcome, with or without significant results. Five of the 10 WHO recommendations were based upon zero analyses with significant results on relevant health outcomes. The remaining recommendations were mostly based upon analyses evaluating obesity-related outcomes. Eight of the 10 GLs thresholds were not supported by any significant analysis on clinically relevant outcomes.
CONCLUSION CONCLUSIONS
While these findings should not be interpreted as an attempt to disprove the benefits of healthy lifestyle habits in early childhood, neither to minimize the work of the experts in this complex research field, very limited evidence currently supports the adoption of recommended thresholds as behavioural surveillance and public health interventions targets. Therefore, until further data are available, public health interventions should be developed balancing whether to focus on the achievement of specific targets that are still not supported by high-quality evidence or on the general promotion of healthy behaviours.

Identifiants

pubmed: 39086022
doi: 10.1111/eci.14294
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e14294

Informations de copyright

© 2024 The Author(s). European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.

Références

Albarqouni L, Ringsten M, Montori V, Jørgensen KJ, Bulbeck H, Johansson M. Evaluation of evidence supporting NICE recommendations to change people's lifestyle in clinical practice: cross sectional survey. BMJ Medicine. 2022;1(1):e000130.
NICE. Overview | weight management: lifestyle services for overweight or obese children and young people | Guidance | NICE. 2013. Available from: https://www.nice.org.uk/guidance/ph47
World Health Organization. WHO Guidelines on Physical Activity and Sedentary Behaviour. World Health Organization; 2020.
Lichtenstein AH, Appel LJ, Vadiveloo M, et al. 2021 dietary guidance to improve cardiovascular health: a scientific statement from the American Heart Association. Circulation. 2021;144(23):e472‐e487.
World Health Organization. Guidelines on Physical Activity, Sedentary Behaviour and Sleep for Children under 5 Years of Age. World Health Organization; 2019.
Lawlor DA, Harbord RM, Sterne JAC, Timpson N, Davey SG. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2008;27(8):1133‐1163.
Grimes DA, Schulz KF. Bias and causal associations in observational research. Lancet. 2002;359(9302):248‐252.
Science Media Centre. Expert reaction to guidance on physical activity, sedentary behaviour and sleep for children under 5 years of age. 2019 Available from: https://www.sciencemediacentre.org/expert‐reaction‐to‐guidance‐on‐physical‐activity‐sedentary‐behaviour‐and‐sleep‐for‐children‐under‐5‐years‐of‐age/
RCPCH. RCPCH responds to WHO physical activity guidelines. 2019. Available from: https://www.rcpch.ac.uk/news‐events/news/rcpch‐responds‐who‐physical‐activity‐guidelines
Achenbach TM. Psychopathology of childhood: research problems and issues. J Consult Clin Psychol. 1978;46(4):759‐776.
Andrews J, Guyatt G, Oxman AD, et al. GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations. J Clin Epidemiol. 2013;66(7):719‐725.
Carson V, Lee EY, Hewitt L, et al. Systematic review of the relationships between physical activity and health indicators in the early years (0–4 years). BMC Public Health. 2017;17(Suppl 5):854.
Chaput J‐P, Gray CE, Poitras VJ, et al. Systematic review of the relationships between sleep duration and health indicators in the early years (0–4 years). BMC Public Health. 2017;17(Suppl 5):855.
Kuzik N, Poitras VJ, Tremblay MS, Lee E‐Y, Hunter S, Carson V. Systematic review of the relationships between combinations of movement behaviours and health indicators in the early years (0–4 years). BMC Public Health. 2017;17(Suppl 5):849.
Poitras VJ, Gray CE, Janssen X, et al. Systematic review of the relationships between sedentary behaviour and health indicators in the early years (0–4 years). BMC Public Health. 2017;17(Suppl 5):868.
Okely AD, Ghersi D, Hesketh KD, et al. A collaborative approach to adopting/adapting guidelines—the Australian 24‐h movement guidelines for the early years (birth to 5 years): an integration of physical activity, sedentary behavior, and sleep. BMC Public Health. 2017;17(Suppl 5):869.
Tremblay MS, Leblanc AG, Carson V, et al. Canadian physical activity guidelines for the early years (aged 0–4 years). Applied PhysiolNut Metab. 2012;37(2):345‐356.
Alonso‐Coello P, Schünemann HJ, Moberg J, et al. GRADE evidence to decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. BMJ. 2016;353:i2016.
World Health Organization. Web Annex. Evidence profiles. WHO Guidelines on Physical Activity, Sedentary Behaviour and Sleep for Children Under 5 Years of Age. World Health Organization; 2019.
Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines: 2. Framing the question and deciding on important outcomes. J Clin Epidemiol. 2011;64(4):395‐400.
R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing; 2023.
Ioannidis JPA. The challenge of reforming nutritional epidemiologic research. JAMA. 2018;320(10):969‐970.
Ioannidis JPA. Implausible results in human nutrition research. BMJ. 2013;347:f6698.
Orben A, Przybylski AK. The association between adolescent well‐being and digital technology use. Nat Hum Behav. 2019;3(2):173‐182.
Phillips SM, Summerbell C, Hobbs M, et al. A systematic review of the validity, reliability, and feasibility of measurement tools used to assess the physical activity and sedentary behaviour of pre‐school aged children. Int J Behav Nutr Phys Act. 2021;18(1):141.
Arts J, Gubbels JS, Verhoeff AP, Chinapaw MJM, Lettink A, Altenburg TM. A systematic review of proxy‐report questionnaires assessing physical activity, sedentary behavior and/or sleep in young children (aged 0–5 years). Int J Behav Nutr Phys Act. 2022;19(1):18.
Alexander PE, Bero L, Montori VM, et al. World Health Organization recommendations are often strong based on low confidence in effect estimates. J Clin Epidemiol. 2014;67(6):629‐634.
Alexander PE, Gionfriddo MR, Li S‐A, et al. A number of factors explain why WHO guideline developers make strong recommendations inconsistent with GRADE guidance. J Clin Epidemiol. 2016;70:111‐122.
Yao L, Ahmed MM, Guyatt GH, et al. Discordant and inappropriate discordant recommendations in consensus and evidence based guidelines: empirical analysis. BMJ. 2021;375:e066045.
Singh Ospina N, Rodriguez‐Gutierrez R, Brito JP, Young WF, Montori VM. Is the endocrine research pipeline broken? A systematic evaluation of the Endocrine Society clinical practice guidelines and trial registration. BMC Med. 2015;13(1):187.
Yao L, Guyatt GH, Djulbegovic B. Can we trust strong recommendations based on low quality evidence? BMJ. 2021;375:n2833.
Sorić M, Meh K, Rocha P, Wendel‐Vos W, de Hollander E, Jurak G. An inventory of national surveillance systems assessing physical activity, sedentary behaviour and sport participation of adults in the European Union. BMC Public Health. 2021;21(1):1797.
Troiano RP, Stamatakis E, Bull FC. How can global physical activity surveillance adapt to evolving physical activity guidelines? Needs, challenges and future directions. Br J Sports Med. 2020;54(24):1468‐1473.
Van Hecke L, Loyen A, Verloigne M, et al. Variation in population levels of physical activity in European children and adolescents according to cross‐European studies: a systematic literature review within DEDIPAC. Int J Behav Nutr Phys Act. 2016;13(1):70.
La sorveglianza ‘Passi’ in Emilia‐Romagna. 2024. Available from: https://salute.regione.emilia‐romagna.it/sanita‐pubblica/sorveglianza/passi‐er
Marques A, Ramirez‐Campillo R, Gouveia ER, et al. 24‐h movement guidelines and overweight and obesity indicators in toddlers, children and adolescents: a systematic review and meta‐analysis. Sports Med Open. 2023;9:30.
Hills AP, Mokhtar N, Byrne NM. Assessment of physical activity and energy expenditure: an overview of objective measures. Front Nutr. 2014;1:5.
Taylor RW, Haszard JJ, Meredith‐Jones KA, et al. 24‐h movement behaviors from infancy to preschool: cross‐sectional and longitudinal relationships with body composition and bone health. Int J Behav Nutr Phys Act. 2018;15(1):118.

Auteurs

Alessandro Bianconi (A)

Section of Hygiene and Preventive Medicine, University of Bologna, Bologna, Italy.

Matteo Fiore (M)

Section of Hygiene and Preventive Medicine, University of Bologna, Bologna, Italy.

Enrico Zauli (E)

Department of Medical Translation, University of Ferrara, Ferrara, Italy.

Cecilia Acuti Martellucci (C)

Local Health Authority of Macerata, Macerata, Italy.

Annalisa Rosso (A)

Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.

Laura Dallolio (L)

Section of Hygiene and Preventive Medicine, University of Bologna, Bologna, Italy.

Maria Elena Flacco (ME)

Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.

Lamberto Manzoli (L)

Section of Hygiene and Preventive Medicine, University of Bologna, Bologna, Italy.

Classifications MeSH