Identifying digital biomarkers of illness activity and treatment response in bipolar disorder with a novel wearable device (TIMEBASE): protocol for a pragmatic observational clinical study.

Bipolar disorder depression digital biomarkers mania physiological data

Journal

BJPsych open
ISSN: 2056-4724
Titre abrégé: BJPsych Open
Pays: England
ID NLM: 101667931

Informations de publication

Date de publication:
01 Aug 2024
Historique:
medline: 1 8 2024
pubmed: 1 8 2024
entrez: 1 8 2024
Statut: epublish

Résumé

Bipolar disorder is highly prevalent and consists of biphasic recurrent mood episodes of mania and depression, which translate into altered mood, sleep and activity alongside their physiological expressions. The IdenTifying dIgital bioMarkers of illnEss activity and treatment response in BipolAr diSordEr with a novel wearable device (TIMEBASE) project aims to identify digital biomarkers of illness activity and treatment response in bipolar disorder. We designed a longitudinal observational study including 84 individuals. Group A comprises people with acute episode of mania ( Recruitment is ongoing. This project should contribute to understanding the pathophysiology of affective disorders. The potential digital biomarkers of illness activity and treatment response in bipolar disorder could be implemented in a real-world clinical setting for clinical monitoring and identification of prodromal symptoms. This would allow early intervention and prevention of affective relapses, as well as personalisation of treatment.

Sections du résumé

BACKGROUND BACKGROUND
Bipolar disorder is highly prevalent and consists of biphasic recurrent mood episodes of mania and depression, which translate into altered mood, sleep and activity alongside their physiological expressions.
AIMS OBJECTIVE
The IdenTifying dIgital bioMarkers of illnEss activity and treatment response in BipolAr diSordEr with a novel wearable device (TIMEBASE) project aims to identify digital biomarkers of illness activity and treatment response in bipolar disorder.
METHOD METHODS
We designed a longitudinal observational study including 84 individuals. Group A comprises people with acute episode of mania (
RESULTS RESULTS
Recruitment is ongoing.
CONCLUSIONS CONCLUSIONS
This project should contribute to understanding the pathophysiology of affective disorders. The potential digital biomarkers of illness activity and treatment response in bipolar disorder could be implemented in a real-world clinical setting for clinical monitoring and identification of prodromal symptoms. This would allow early intervention and prevention of affective relapses, as well as personalisation of treatment.

Identifiants

DOI: 10.1192/bjo.2024.716 PMID: 39086306
pubmed: 39086306
doi: 10.1192/bjo.2024.716
pii: S2056472424007166
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e137

Subventions

Organisme : Milken Family Foundation
ID : PI046998
Organisme : Instituto de Salud Carlos III
ID : PI21/00340

Auteurs

Gerard Anmella (G)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-6798-4054

Filippo Corponi (F)

School of Informatics, University of Edinburgh, UK.
ORCID: 0000-0002-6807-0617

Bryan M Li (BM)

School of Informatics, University of Edinburgh, UK.
ORCID: 0000-0003-3144-4838

Ariadna Mas (A)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-8738-8655

Marina Garriga (M)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0001-7312-4969

Miriam Sanabra (M)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0003-2206-2264

Isabella Pacchiarotti (I)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-7822-0367

Marc Valentí (M)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-9783-6220

Iria Grande (I)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-0137-0666

Antoni Benabarre (A)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0001-8814-2246

Anna Giménez-Palomo (A)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-9474-6473

Isabel Agasi (I)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain.
ORCID: 0000-0002-0381-7951

Anna Bastidas (A)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0001-8240-1438

Myriam Cavero (M)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-5283-5523

Miquel Bioque (M)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; and Barcelona Clinic Schizophrenia Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
ORCID: 0000-0001-6887-7149

Clemente García-Rizo (C)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; and Barcelona Clinic Schizophrenia Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
ORCID: 0000-0002-4855-1608

Santiago Madero (S)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; and Barcelona Clinic Schizophrenia Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
ORCID: 0000-0002-1123-4211

Néstor Arbelo (N)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; and Barcelona Clinic Schizophrenia Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
ORCID: 0000-0002-2630-3259

Andrea Murru (A)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0001-6320-4420

Silvia Amoretti (S)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0001-6017-2734

Anabel Martínez-Aran (A)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-0623-6263

Victoria Ruiz (V)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain.
ORCID: 0000-0001-9198-4663

Yudit Rivas (Y)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain.
ORCID: 0009-0004-1297-3843

Giovanna Fico (G)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0003-1785-7126

Michele De Prisco (M)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-2032-1181

Vincenzo Oliva (V)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-5961-6032

Aleix Solanes (A)

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; and Imaging of Mood- and Anxiety-Related Disorders (IMARD) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
ORCID: 0000-0002-2491-200X

Joaquim Radua (J)

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; Institute of Neurosciences (UBNeuro), University of Barcelona, Spain; Imaging of Mood- and Anxiety-Related Disorders (IMARD) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Early Psychosis: Interventions & Clinical Detection (EPIC) Laboratory, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; and Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden.
ORCID: 0000-0003-1240-5438

Ludovic Samalin (L)

Institut Pascal (UMR 6602), Department of Psychiatry, CHU Clermont-Ferrand, University of Clermont Auvergne, CNRS, Clermont Auvergne INP, France; and Association Française de Psychiatrie Biologique et Neuropsychopharmacologie (AFPBN), Saint Germain en Laye, France.
ORCID: 0000-0003-0740-4019

Allan H Young (AH)

Centre for Affective Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
ORCID: 0000-0003-2291-6952

Antonio Vergari (A)

School of Informatics, University of Edinburgh, UK.
ORCID: 0000-0003-0036-5678

Eduard Vieta (E)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-0548-0053

Diego Hidalgo-Mazzei (D)

Digital Innovation Group, Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Department of Psychiatry and Psychology, Hospital Clínic de Barcelona, Spain; Department of Psychiatry and Psychology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Spain; and Institute of Neurosciences (UBNeuro), University of Barcelona, Spain.
ORCID: 0000-0002-2693-6849

Classifications MeSH