Endometriosis and risk of adverse pregnancy outcomes: a retrospective multicenter cohort study.

To investigate: first, the association between endometriosis and preterm birth; second, the associations between endometriosis and preeclampsia, placenta previa, postpartum hemorrhage, stillbirth, and small-for-gestational-age infants (assessed by birthweight); and third, the risk of these adverse pregnancy outcomes with and without the use of medically assisted reproduction. Multicenter retrospective cohort study. 103 French maternity units. Deliveries by 368,935 women (377,338 infants) from 1999 through 2016. Endometriosis, defined as a single disease entity (endometriosis and/or ademyosis). The main outcome was the preterm birth rate (both < 37 and < 33 weeks). The secondary outcomes were rates of preeclampsia, placenta previa, postpartum hemorrhage, stillbirth, and small-for-gestational-age neonates. Women in the endometriosis group had more frequent histories of infertility before the included pregnancy (34.7 vs 5.0%, P <10 Pregnant women with endometriosis had higher risks of preterm birth and other poor pregnancy outcomes than women without endometriosis.

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