Flow Cytometry-based Immune Phenotyping of T and B Lymphocytes in the Evaluation of Immunodeficiency and Immune Dysregulation.
Flow cytometry
Immune dysregulation
Inborn errors of immunity
Primary immunodeficiency
Journal
Clinics in laboratory medicine
ISSN: 1557-9832
Titre abrégé: Clin Lab Med
Pays: United States
ID NLM: 8100174
Informations de publication
Date de publication:
Sep 2024
Sep 2024
Historique:
medline:
2
8
2024
pubmed:
2
8
2024
entrez:
1
8
2024
Statut:
ppublish
Résumé
There are approximately 500 congenital disorders that impair immune cell development and/or function. Patients with these disorders may present with a wide range of symptoms, including increased susceptibility to infection, autoimmunity, autoinflammation, lymphoproliferation, and/or atopy. Flow cytometry-based immune phenotyping of T and B lymphocytes plays an essential role in the evaluation of patients with these presentations. In this review, we describe the clinical utility of flow cytometry as part of a comprehensive evaluation of immune function and how this testing may be used as a diagnostic tool to identify underlying aberrant immune pathways, monitor disease activity, and assess infection risk.
Identifiants
pubmed: 39089753
pii: S0272-2712(24)00020-9
doi: 10.1016/j.cll.2024.04.009
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
479-493Informations de copyright
Copyright © 2024 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure A. A. Nguyen is a staff physician at Boston Children’s Hospital and Instructor of Pediatrics at Harvard Medical School. C. D. Platt is a staff physician and Medical Director of Flow Cytometry at Boston Children’s Hospital, and Assistant Professor of Pediatrics at Harvard Medical School. The spouse of C. D. Platt is employed by Quest Diagnostics. A. A. Nguyen has nothing to disclose.