Flow Cytometry and Platelets.

Humans Flow Cytometry Blood Platelets Platelet Activation Platelet Function Tests Blood Platelet Disorders / diagnosis Biomarkers / blood
Blood platelet disorders Flow cytometry Function tests Phenotyping Platelet Platelet activation Thrombocytopenia

Journal

Clinics in laboratory medicine
ISSN: 1557-9832
Titre abrégé: Clin Lab Med
Pays: United States
ID NLM: 8100174

Informations de publication

Date de publication:
Sep 2024
Historique:
medline: 2 8 2024
pubmed: 2 8 2024
entrez: 1 8 2024
Statut: ppublish

Résumé

Clinical assessment of platelet activation by flow cytometry is useful in the characterization and diagnosis of platelet-specific disorders and as a measure of risk for thrombosis or bleeding. Platelets circulate in a resting, "unactivated" state, but when activated they undergo alterations in surface glycoprotein function and/or expression level, exposure of granule membrane proteins, and exposure of procoagulant phospholipids. Flow cytometry provides the means to detect these changes and, unlike other platelet tests, is appropriate for measuring platelet function in samples from patients with low platelet counts. The present review will focus on flow cytometric tests for platelet activation markers.

Identifiants

DOI: 10.1016/j.cll.2024.04.011 PMID: 39089755
pubmed: 39089755
pii: S0272-2712(24)00022-2
doi: 10.1016/j.cll.2024.04.011
pii:
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

511-526

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The author has nothing to disclose.

Auteurs

Andrew L Frelinger (AL)

Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115-5737, USA. Electronic address: Andrew.Frelinger@childrens.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Flow Cytometry and Platelets.
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Flow Cytometry and Platelets.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Plaquettes › Flow Cytometry and Platelets.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Activation plaquettaire › Flow Cytometry and Platelets.
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Tests hématologiques › Tests fonctionnels plaquettaires › Flow Cytometry and Platelets.
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Anomalies des plaquettes › Flow Cytometry and Platelets.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Flow Cytometry and Platelets.