Current Thoughts on Burn Resuscitation.
Albumin
Burns
Colloid
Crystalloid
Endothelium
Glycocalyx
Resuscitation
Journal
Advances in surgery
ISSN: 1878-0555
Titre abrégé: Adv Surg
Pays: United States
ID NLM: 0045335
Informations de publication
Date de publication:
Sep 2024
Sep 2024
Historique:
medline:
2
8
2024
pubmed:
2
8
2024
entrez:
1
8
2024
Statut:
ppublish
Résumé
The optimal treatment of burn shock is still unresolved. The problem of "fluid creep" continues despite modern devices that fail to improve outcomes over hourly urine output. Colloids, especially albumin, reduce fluid requirements. Albumin can be used either immediately at the start of resuscitation, or as a "rescue" when crystalloid use is excessive. Several studies confirm that when crystalloid resuscitation is "out of control" the majority of caregivers will add albumin to reduce fluid rates. A multi-center trial is underway comparing crystalloids with albumin to confirm the benefit of colloids. The next question is whether albumin or plasma is as the better colloid choice.
Identifiants
pubmed: 39089770
pii: S0065-3411(24)00001-0
doi: 10.1016/j.yasu.2024.04.001
pii:
doi:
Substances chimiques
Albumins
0
Crystalloid Solutions
0
Colloids
0
Isotonic Solutions
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-17Informations de copyright
Copyright © 2024 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure The author is Principle Investigator of one current Department of Defense Grant (W81XWH-19-1-664.JW180038, Acute Burn ResUscitation Prospective Multicenter Trial 2 [ABRUPT2]) (ClinicalTrials.gov – NCT04356859) that compares the use of albumin to lactated Ringer’s solution, and one completed Department of Defense grant (W81XWH-16-2-0048, Acute Burn ResUscitation Prospective Multicenter Trial [ABRUPT]) (ClinicalTrials.gov – NCT03144427) that are described in the paper.