The ATP-driven extractor ATAD1/Msp1 proof-reads protein translocation into mitochondria.
AAA protein
cancer
integrated stress response (ISR)
mitochondria
protein import
quality control
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
31 Jul 2024
31 Jul 2024
Historique:
received:
03
07
2024
accepted:
19
07
2024
medline:
2
8
2024
pubmed:
2
8
2024
entrez:
1
8
2024
Statut:
aheadofprint
Résumé
The accumulation of translocation intermediates in the mitochondrial import machinery threatens cellular fitness and is associated with cancer and neurodegeneration. A recent study by Weidberg and colleagues identifies ATAD1 as an ATP-driven extraction machine on the mitochondrial surface that pulls precursors into the cytosol to prevent clogging of mitochondrial import pores.
Identifiants
pubmed: 39089957
pii: S0962-8924(24)00145-4
doi: 10.1016/j.tcb.2024.07.007
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.