The interaction of genetics and physical activity in the pathogenesis of metabolic dysfunction associated liver disease.
CLD
Gene-environment interactions
IPAQ
Liver fat
Liver volume
MASLD
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 Aug 2024
01 Aug 2024
Historique:
received:
12
04
2024
accepted:
22
07
2024
medline:
2
8
2024
pubmed:
2
8
2024
entrez:
1
8
2024
Statut:
epublish
Résumé
Genetic variants associated with increased liver fat and volume have been reported, but whether physical activity (PA) can attenuate the impact of genetic susceptibility to these traits is poorly understood. We aimed to investigate whether higher PA modify genetic impact on liver-related traits in the UK Biobank cohort. PA was self-reported, while magnetic resonance images were used to estimate liver fat (n = 27,243) and liver volume (n = 24,752). Metabolic dysfunction-associated liver disease (MASLD) and chronic liver disease (CLD) were diagnosed using ICD-9 and ICD-10 codes. Ten liver fat and eleven liver volume-associated genetic variants were selected and unweighted genetic-risk scores for liver fat (GRS
Identifiants
pubmed: 39090170
doi: 10.1038/s41598-024-68271-4
pii: 10.1038/s41598-024-68271-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17817Subventions
Organisme : European Research Council
ID : GUTSY - 801965
Pays : International
Organisme : Vetenskapsrådet
ID : 2015-03477
Organisme : Vetenskapsrådet
ID : 2018-02784
Organisme : Vetenskapsrådet
ID : 2019-04756
Organisme : Vetenskapsrådet
ID : 2016-01040
Organisme : Vetenskapsrådet
ID : 2022-01460
Organisme : Swedish Heart-Lung Foundation
ID : 20200500
Organisme : Swedish Heart-Lung Foundation
ID : 20220129
Organisme : Swedish Cancer Foundation
ID : 21 0456 FE
Organisme : FORMAS
ID : 2020-00989
Informations de copyright
© 2024. The Author(s).
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