Preventing radiation-induced dysphagia and trismus in head and neck cancer-A randomized controlled trial.
deglutition disorders
head and neck neoplasms
intervention study
radiotherapy
randomized
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
01 Aug 2024
01 Aug 2024
Historique:
revised:
24
06
2024
received:
11
04
2024
accepted:
09
07
2024
medline:
2
8
2024
pubmed:
2
8
2024
entrez:
2
8
2024
Statut:
aheadofprint
Résumé
Radiation-induced dysphagia and restricted mouth opening are common problems among patients with head and neck cancer. The aim of the present randomized controlled trial was to determine if an exercise protocol could prevent swallowing and mouth opening impairment. Eighty-nine participants were randomly assigned to either an active group performing preventive swallowing and mouth opening exercises (n = 45) or to a control group (n = 44). Outcome measures were collected at baseline before radiotherapy and approximately 1-month post-treatment. Primary endpoints were changes in swallowing function according to the Penetration Aspiration Scale and mouth opening ability measured in millimeters. Intention-to-treat analysis was used. Swallowing function and mouth opening deteriorated in both groups, with no statistically significant positive effect of the protocol detected at follow-up. Among patients who completed >75% of exercises, there was a trend toward better outcomes. Preventive exercises did not improve short-term swallowing function and mouth opening after radiotherapy.
Sections du résumé
BACKGROUND
BACKGROUND
Radiation-induced dysphagia and restricted mouth opening are common problems among patients with head and neck cancer. The aim of the present randomized controlled trial was to determine if an exercise protocol could prevent swallowing and mouth opening impairment.
METHODS
METHODS
Eighty-nine participants were randomly assigned to either an active group performing preventive swallowing and mouth opening exercises (n = 45) or to a control group (n = 44). Outcome measures were collected at baseline before radiotherapy and approximately 1-month post-treatment. Primary endpoints were changes in swallowing function according to the Penetration Aspiration Scale and mouth opening ability measured in millimeters. Intention-to-treat analysis was used.
RESULTS
RESULTS
Swallowing function and mouth opening deteriorated in both groups, with no statistically significant positive effect of the protocol detected at follow-up. Among patients who completed >75% of exercises, there was a trend toward better outcomes.
CONCLUSIONS
CONCLUSIONS
Preventive exercises did not improve short-term swallowing function and mouth opening after radiotherapy.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Anna-Lisa and Bror Björnsson Foundation
Organisme : Assar Gabrielsson Foundation
Organisme : Sjöberg Foundation
Organisme : Lions Cancer Foundation West
Organisme : Swedish Cancer Foundation
Organisme : Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement
Organisme : The Health & Medical Care Comittee of the Region Västra Götaland
Informations de copyright
© 2024 The Author(s). Head & Neck published by Wiley Periodicals LLC.
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